Up-Regulation of Anthranilic Acid Formation and Pro-Cognitive Effect of Indoleamine 2,3-Dioxygenase Inhibition [0.03%]
反式苯乙炔酸的生成增强及色氨酸2，3双氧化酶抑制的认知促进作用
Gregory Oxenkrug,Stefano Comai
Gregory Oxenkrug
Inhibition of indoleamine 2,3-dioxygenase (IDO) is a promising therapeutic strategy for cognitive impairment in Alzheimer's disease (AD). The pro-cognitive effect is often attributed to restoring glycolysis by preventing tryptophan (Trp) co...
Urinary Tryptophan Metabolites, Trace Element Status, and Autism Spectrum Disorder: An Integrated Metabolomics-Elementomics Study in Children [0.03%]
儿童尿色氨酸代谢物、微量元素状态与自闭症谱系障碍的整合代谢组-元素组研究
Joško Osredkar,Kristina Kumer,Maja Jekovec Vrhovšek et al.
Joško Osredkar et al.
Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with metabolic and environmental factors. We investigated associations between urinary tryptophan-pathway metabolites and essential/toxic trace elements in children...
The Role of Downstream Kynurenine Pathway Metabolites in the Modulation of Cardiovascular Disease Development in Chronic Kidney Disease [0.03%]
慢性肾脏病患者下游犬尿氨酸代谢产物在心血管疾病发病机制中的作用研究
Magdalena Zabłudowska,Magdalena Kopańko,Beata Sieklucka et al.
Magdalena Zabłudowska et al.
Cardiovascular diseases (CVDs) represent a significant and escalating health challenge in patients with chronic kidney disease (CKD). In this population, the cardiovascular incidents are markedly elevated, and CVD represents the leading cau...
Latent Cerebral Toxoplasma Gondii Infection Induces the Kynurenine Pathway and Production of Neurotoxic Metabolites [0.03%]
隐性小鼠脑内弓形虫感染诱导犬尿氨酸代谢并产生神经毒素
Amir Mohamed Kezai,Mahmoudou Ba,Benjamin Hennart et al.
Amir Mohamed Kezai et al.
The kynurenine pathway (KP) has been implicated in a broad range of neurological disorders. KP activation in brain resident immune cells, including astrocytes and microglia, contributes to the release of neuroactive metabolites with strong ...
Interaction of Hypoxia and Kynurenine Pathway in Periodontal Inflammation [0.03%]
牙周炎症中缺氧与犬尿酸途径的相互作用
Ardita Koci,Sivge Kurgan,Nur Balci et al.
Ardita Koci et al.
The kynurenine pathway (KP), the primary route of tryptophan (TRP) metabolism, is influenced by inflammation and hypoxia and has been linked to immune dysregulation and oxidative stress. This study investigated the relationship between KP a...
Potential Treatment for ADHD Based on Recovery from Tryptophan-Induced Central Fatigue by Powerful Competitive Inhibition of L-System Amino Acid Transporter [0.03%]
基于色氨酸诱导的中枢疲劳恢复治疗ADHD：强有力的L-系统氨基酸转运的竞争性抑制作用
Takanobu Yamamoto,Bianca Koleda-Yamamoto
Takanobu Yamamoto
Fatigability in attention deficit hyperactivity disorder (ADHD) is associated with the characteristic inattention behavior. Evidence has indicated that the administration of branched-chain amino acids (BCAAs) to Nagase analbuminemic rats (N...
Benoît Gendrot,Cathy Vaillancourt,Guillemette Fouquet
Benoît Gendrot
Tryptophan is an essential amino acid required for protein synthesis and a precursor of key bioactive metabolites produced through the kynurenine, indole and serotonin pathways. Beyond its nutritional role, tryptophan metabolism critically ...
Corrigendum to "Development of a Novel Method to Quantify Quinolinic Acid in Biological Samples" [0.03%]
关于“一种新的测定生物样本中夸西萘酸含量的方法的开发”的勘误通知
[This corrects the article DOI: 10.1177/11786469251390415.]. © The Author(s) 2026.
Rice Bran Arabinoxylan Compound and Tryptophan Metabolism on Quality of Life of Cancer Patients: A Secondary Analysis of the RBAC-QoL Study [0.03%]
米糠阿拉伯木聚糖化合物和色氨酸代谢对癌症患者生活质量的影响：RBAC-QoL研究的二次分析
Soo Liang Ooi,Benjamin Kimble,Benjamin S Pak et al.
Soo Liang Ooi et al.
Tryptophan metabolism, with its breakdown along the kynurenine pathway, is linked to the diminishing quality of life (QoL) of cancer patients. Rice bran arabinoxylan compound (RBAC) is a plant-based immunomodulator shown to improve the glob...
Cerebrospinal Fluid, Plasma Tryptophan, Kynurenine, and Kynurenate with Sleep Phenotypes: A Bidirectional Mendelian Randomization Analysis [0.03%]
睡眠表型的脑脊液、血浆色氨酸、犬尿酸和犬尿酸代谢物的 mendelian 随机化分析
Qin Xie,Guangya Liu,Xiaolan Liu
Qin Xie
Sleep is crucial for physiological regulation in humans and essential for sustaining life. Although melatonin, an intermediate in the tryptophan (TRP)-serotonin pathway, is widely explored as a modulator of the sleep-wake cycle, the associa...