Glucocorticoid Treatment Dampens Kynurenine Pathway Activation and Cytokine Release in Immune Stimulated Human Microglia [0.03%]
糖皮质激素治疗可抑制人类小胶质细胞中促炎刺激诱导的犬尿氨酸代谢通路激活及细胞因子释放
Martina Esposito Soccoio,Robert P Mason,Julien Devilliers et al.
Martina Esposito Soccoio et al.
As a first line of defence for the central nervous system (CNS), microglia play a critical role in maintaining homeostasis within the brain. Upon detection of damage or threats, activated cells release factors to communicate and potentiate ...
Kynurenine Pathway Dysregulation in Parkinson's Disease: Insights for Disease Modulation and Therapy [0.03%]
帕金森病中的犬尿酸途径失调：对疾病调控和治疗的启示
Vaibhav A Chakkarwar,Yogesh A Kulkarni
Vaibhav A Chakkarwar
Parkinson's disease (PD) is identified as the most common neurodegenerative disorder of the central nervous system. Around 8.5 million individuals suffer from PD globally. Neuroinflammation triggers the activation of microglia, resulting in...
Development of a Novel Method to Quantify Quinolinic Acid in Biological Samples [0.03%]
一种定量生物样本中喹啉酸的新方法的开发研究论文
Masatsuna Tasaka,Hidetsugu Fujigaki,Sayaka Sugiura et al.
Masatsuna Tasaka et al.
Background: The accumulation of quinolinic acid (QUIN) in cerebrospinal fluid and serum may be used as a biomarker for various neuropsychiatric and inflammatory diseases. In this study, we developed a highly sensitive met...
Neuroactive Kynurenine Metabolite Alterations Unveil Novel Association to Locomotor Deterioration in Diabetic Neuropathy [0.03%]
神经活性犬尿素代谢物的改变揭露了糖尿病周围神经病变与运动功能损伤的新关联
Alejandra Perez-Alvarez,Victor Salazar,Gustavo Bruges et al.
Alejandra Perez-Alvarez et al.
Background: The effect of prolonged hyperglycemia on the sensory pathway of the nervous system has been the focus of numerous diabetes studies that aim at understanding the pathophysiology of the underlying inflammatory c...
Molecular Insights Into the Interaction of Tryptophan Metabolites With Tryptophan and Indoleamine 2,3-Dioxygenases: Nitric Oxide a New Effector of Tryptophan 2,3-Dioxygenase and Their Roles in Infection [0.03%]
色氨酸代谢产物与色氨酸和吲哚胺2，3-双氧酶相互作用的分子见解：一氧化氮是一种新的色氨酸2,3-过氧化物抑制剂及其在感染中的作用
Abdulla A-B Badawy,Shazia Dawood
Abdulla A-B Badawy
Feedback and other negative controls are important determinants of metabolic pathway activities. Other than inhibition of indoleamine 2,3-dioxygenase (IDO) by tryptophan (Trp) and nitric oxide (NO) and feedback inhibition of Trp 2,3-dioxyge...
Activation of the IDO1-GCN2-ATF4-CHOP Pathway During the Massive Generation of Antibody-Secreting Cells in Dengue Patients Through Single-Cell Transcriptomics [0.03%]
单细胞转录组学揭示登革热患者通过大量生成抗体分泌细胞激活IDO1-GCN2-ATF4-CHOP通路
Jéssica C Nascimento,André N A Gonçalves,Karen T Akashi et al.
Jéssica C Nascimento et al.
Dengue, a widespread mosquito-borne disease, annually afflicts millions globally, posing substantial mortality risks. Preceding disease defervescence, a marked and transient surge in antibody-secreting cell (ASC) frequency correlates with d...
IBS May Have a Causal Effect on Increased Tryptophan Metabolites Levels: Insights from a Bidirectional Two-Sample Mendelian Randomization Study [0.03%]
基于双向孟德尔随机化研究的肠易激综合征可能对增加的色氨酸代谢物水平具有因果效应：见解
Peilin Cheng,Ruzhen Jia,Bingjie Jin et al.
Peilin Cheng et al.
Background: Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain and altered bowel habits. Tryptophan, an essential amino acid derived from dietary proteins, can...
Preoperative Peripheral Blood Serotonin and Kynurenine Levels Are Associated With Oncological Outcomes in Glioblastoma IDH-wt Patients [0.03%]
术前外周血5-羟色胺和犬尿氨酸水平与IDH-wt型胶质母细胞瘤患者的肿瘤预后相关
Silvia Snider,Filippo Gagliardi,Pierfrancesco De Domenico et al.
Silvia Snider et al.
Background: In recent years, there has been a growing interest in exploring the potential contribution of tryptophan (TRP) metabolism via the kynurenine (KP) and serotonin (SP) pathways in Glioblastoma (GBM) biology. This...
Relationship Between Psychological Stress Scores and Urinary 5-HT Levels Over Time Under Psychological Stress [0.03%]
心理应激下心理应激评分与尿液5-羟色胺水平变化的关联分析
Tadayuki Iida,Yasuhiro Ito,Susumu Murayama et al.
Tadayuki Iida et al.
Background: Biomarkers for psychological stress have been examined and the "gut-microbiota-brain axis" is currently attracting attention. An intervention study reported improvements in both the intestinal environment and ...
Baseline Inflammation but not Exercise Modality Impacts Exercise-induced Kynurenine Pathway Modulation in Persons With Multiple Sclerosis: Secondary Results From a Randomized Controlled Trial [0.03%]
基线炎症但不是运动形式影响多发性硬化症患者运动诱导的犬尿氨酸通路调节：随机对照试验的次要结果
Marie Kupjetz,Nadine Patt,Niklas Joisten et al.
Marie Kupjetz et al.
Background: The kynurenine pathway (KP) is an important hub in neuroimmune crosstalk that is dysregulated in persons with multiple sclerosis (pwMS) and modulated by exercise in a modality-specific manner. ...