First-line tepotinib for a very elderly patient with metastatic NSCLC harboring MET exon 14 skipping mutation and high PD-L1 expression [0.03%]
替泊利单抗治疗高PD-L1表达的转移性MET外显子14跳跃突变非小细胞肺癌非常老年患者的一线治疗案例报告
Alessandro Inno,Giuseppe Bogina,Giulio Settanni et al.
Alessandro Inno et al.
Optimal treatment for metastatic non-small cell lung cancer (NSCLC) with mesenchymal epithelial transition gene (MET) exon 14 skipping mutation has not been established yet. MET inhibitors were demonstrated to be effective and tolerated in ...
Case Reports
Drug target insights. 2023 Oct 6:17:110-113. DOI:10.33393/dti.2023.2626 2023
Prevalence of antibiotic misuse in cases of pneumonia and diarrhea in Saudi Arabia [0.03%]
沙特阿拉伯肺炎和腹泻病例中抗生素误用的流行率
Ebtehaj Saud Almughais,Fatmah Fahad Alreshidi,Hussain Gadelkarim Ahmed
Ebtehaj Saud Almughais
Background: Antibiotic misuse is a major public health issue with long-term repercussions. Objective: The purpose of this investigation...
Identification of anti-pathogenic activity among in silico predicted small-molecule inhibitors of Pseudomonas aeruginosa LasR or nitric oxide reductase (NOR) [0.03%]
计算识别假单胞菌LasR或一氧化氮还原酶(NOR)的小分子抑制剂的抗病原作用
Gemini Gajera,Niel Henriksen,Bryan Cox et al.
Gemini Gajera et al.
Introduction: Antibiotic-resistant Pseudomonas aeruginosa strains cause considerable morbidity and mortality globally. Identification of novel targets in this notorious pathogen is urgently warranted to facilitate discove...
ESBL and carbapenemase-producing Enterobacteriaceae in infectious pleural effusions: current epidemiology at Hôpital du Mali [0.03%]
产ESBL和碳青霉烯酶肠杆菌科感染性胸腔积液的流行病学现状——马里医院报告
Aimé Césaire Kalambry,Tchamou Malraux Fleury Potindji,Ibrehima Guindo et al.
Aimé Césaire Kalambry et al.
Background: Antimicrobial resistance (AMR) is a global health concern, with extended-spectrum β-lactamases (ESBLs) and carbapenemases being major contributors. Pleural infection (PI) is a severe condition in West Africa,...
Activity of sotorasib against brain metastases from NSCLC harboring KRAS p.G12C mutation: a case report [0.03%]
索托雷塞对NSCLC脑转移瘤携带KRAS p.G12C突变的活性：一例报告
Alessandro Inno,Fabiana Marchetti,Matteo Valerio et al.
Alessandro Inno et al.
In the CodeBreaK 100 phase 2 study, sotorasib was active for patients with metastatic non-small cell lung cancer (NSCLC) harboring Kirsten rat sarcoma viral oncogene homologue (KRAS) p.G12C mutation. However, patients with untreated and/or ...
Case Reports
Drug target insights. 2023 Jun 20:17:90-91. DOI:10.33393/dti.2023.2593 2023
Efficacy of LAMP assay for Mycobacterial spp. detection to prevent treatment delays and onset of drug resistance: a systematic review and meta-analysis [0.03%]
用于检测麻风分枝杆菌等防止治疗延误和药物耐药发生的LAMP检测试剂盒有效性的系统评价和meta分析
Gurvinder Singh Bumbrah,Sarika Jain,Zeeshan Fatima et al.
Gurvinder Singh Bumbrah et al.
Background: Tuberculosis (TB) remains a deadly disease affecting one-third population globally. Long turnaround time and poor sensitivity of the conventional diagnostics are the major impediments for faster diagnosis of M...
Safiya Fatima Khan,Bhavya Shetty,Ibrahim Fazal et al.
Safiya Fatima Khan et al.
Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice (Glycyrrhiza glabra) is...
Network analysis for identifying potential anti-virulence targets from whole transcriptome of Pseudomonas aeruginosa and Staphylococcus aureus exposed to certain anti-pathogenic polyherbal formulations [0.03%]
网络分析鉴定潜在的抗细菌活性靶点：全转录组与某些抗病草药配方对绿脓杆菌和金黄色葡萄球菌的作用
Feny J Ruparel,Siddhi K Shah,Jhanvi H Patel et al.
Feny J Ruparel et al.
Introduction: Antimicrobial resistance (AMR) is a serious global threat. Identification of novel antibacterial targets is urgently warranted to help antimicrobial drug discovery programs. This study attempted identificati...
Ratchanon Rattanathanoo,Jarin Chindaprasirt,Watchara Boonsawat et al.
Ratchanon Rattanathanoo et al.
Background:: Calcium channel blocker (CCB) is a common antihypertensive agent for the treatment of hypertension. There are inconsistent data of an association of CCB and lung cancer in the literature. This study aimed to ...
Lipid profiles of people with human immunodeficiency virus with dyslipidemia after switching from efavirenz to dolutegravir [0.03%]
人免疫缺陷病毒患者在接受替诺福韦和富马酸替拉依酯联合治疗的基础上加用多替拉韦钠片后血脂状况改善的横断面研究
Supphachoke Khemla,Atibordee Meesing,Wantin Sribenjalux et al.
Supphachoke Khemla et al.
Introduction:: Human immunodeficiency virus (HIV) infection and the long-term use of antiretroviral therapy, especially efavirenz (EFV)-based regimens, impact lipid profiles due to insulin resistance and lead to a higher ...