Withania somnifera root extract reduces susceptibility of the model worm Caenorhabditis elegans to different types of stressors [0.03%]
Withania somnifera根提取物可降低模式线虫Caenorhabditis elegans对不同类型胁迫的敏感性
Nidhi Thakkar,Dilip Mehta,Vijay Kothari
Nidhi Thakkar
Introduction: Withania somnifera, commonly known as Ashwagandha, is one of the most widely prescribed plants in the Indian system of traditional medicine. Its roots are believed to impart comprehensive health benefits sup...
Comparative effects of Helmar-1 and Helmar-2 polyphenol extracts on mitochondrial bioenergetics, antioxidant defense, and lipid peroxidation in CCl₄-induced toxic hepatitis in rats [0.03%]
Helmar-1和Helmar-2多酚提取物对四氯化碳致大鼠肝毒性作用下线粒体生物能学、抗氧化防御及脂质过氧化的比较效应
Saidahon Ahmedova,Muzaffar Asrarov,Sobitjon Mirzakulov et al.
Saidahon Ahmedova et al.
Introduction: Toxic hepatitis is characterized by enhanced oxidative stress and disruption of antioxidant defense mechanisms in the liver mitochondria. In this study, we investigated the effects of polyphenolic extracts (...
Molecular docking and dynamics analysis of selected phytocompounds against multi-targeted hepatocellular carcinoma [0.03%]
几种植物化合物治疗肝癌分子对接及动态分析研究
Narendran Chiterasu,Swarnalatha Yanamandala,Senthilkumar Chinnaiyan et al.
Narendran Chiterasu et al.
Introduction: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide, with a five-year survival rate of only 19%. Although Sorafenib is the primary systemic therapy, its limited effi...
Vijay Kothari
Vijay Kothari
Antioxidant potential of a new macrocyclic bisbibenzyl and other compounds from Combretum molle: in vitro and docking analyses [0.03%]
Combretum molle中新macrocycle双bibenzyl及其他化合物的抗氧化潜力：体外及对接分析
Angele Fanta,Gaetan Bayiha Ba Njock,Amadou Dawe et al.
Angele Fanta et al.
Introduction: Free radicals are key contributors to several diseases, including cancer, inflammation, pain, and neurodegenerative disorders such as Alzheimer's disease. Due to the limitations and adverse effects of synthe...
Ravulizumab in treatment-naïve patients with atypical hemolytic uremic syndrome: a real-world case series [0.03%]
拉珠利单抗在初治典型溶血性尿毒综合征患者中的疗效：真实世界个案系列研究报告
Sorrentino Livia Maria,Candida Iacuzzo,Raffaela Sciri et al.
Sorrentino Livia Maria et al.
Introduction: Atypical hemolytic uremic syndrome (aHUS) is a potentially life-threatening condition associated with poor clinical outcomes if not treated adequately. Eculizumab has become the standard of care, whereas rav...
Co-occurrence of genes encoding carbapenem resistance and aminoglycoside resistance in clinical isolates of Enterobacterales [0.03%]
临床分离的肠杆菌目中碳青霉烯耐药和氨基糖苷耐药基因的共存
Shradha Smriti,Gaurav Verma,Sujit Pradhan et al.
Shradha Smriti et al.
Introduction: This study aimed to detect the co-occurrence of carbapenem resistance genes along with aminoglycoside-modifying enzyme (AME) genes in clinical Enterobacterales isolates to understand the distribution of mult...
The Bushenhuoxue formula improves prothrombotic state in recurrent spontaneous abortion: network pharmacology and experimental validation [0.03%]
补血活血汤改善复发性流产促凝状态的网络药理学及实验验证
Xuan Yang,Shulan Su,Lijing Liu et al.
Xuan Yang et al.
Introduction: Bushenhuoxue formula is a traditional Chinese medicine formula with relatively safe clinical effects, but its mechanism in recurrent spontaneous abortion (RSA) is still unclear. Our present study used Networ...
Integrated in vitro, microarray, and network pharmacology analysis reveals the multi-target anti-diabetic potential of Vigna unguiculata [0.03%]
集成体外实验，微阵列和网络药理学分析揭示了伏击花扁袖李的多种抗糖尿病潜力
Haseeba Sardar,Fatima Noor,Syed Muhammad Mukarram Shah et al.
Haseeba Sardar et al.
Introduction: Diabetes mellitus (DM), particularly type 2 DM (T2DM), is a chronic metabolic disorder requiring novel therapeutic approaches as the available therapies are not meeting the current challenges. This study inv...
Integrative in silico and Petra/Osiris/Molinspiration (POM) analysis of baicalein: identification of therapeutically relevant pharmacophores against keloid pathology [0.03%]
黄芩素的综合计算机及Petra/Osiris/Molinspiration(POM)分析：鉴定针对瘢痕病理的治疗相关药效团
Abhay P Mishra,Anothai Tangsumranjit,Manisha Nigam et al.
Abhay P Mishra et al.
Introduction: Keloid scars are a kind of skin disorder in which the scar grows beyond the boundaries of the original wound. Baicalein, a flavonoid, may treat keloids by targeting fibrosis, inflammation, and possible viral...