Circulating vascular endothelial growth factor (VEGF) levels in advanced stage cancer patients compared to normal controls and diabetes mellitus patients with critical ischemia [0.03%]
晚期癌症患者与正常对照组和糖尿病重症缺血患者的循环血管内皮生长因子(VEGF)水平比较
Yoka H Kusumanto,Coby Meijer,Wendy Dam et al.
Yoka H Kusumanto et al.
Anti-angiogenic therapy is emerging as a valuable tool in the treatment of patients with cancer. As VEGF is a central target in anti-angiogenic therapy, its levels in the circulation might be relevant in selecting tumor types or patients li...
Cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions [0.03%]
青风藤碱的心血管药理作用及机械和电生理效应
Seiichiro Nishida,Hiroyasu Satoh
Seiichiro Nishida
Sinomenine is one of the alkaloids extracted from Chinese medical plant, Sinomenium acutum Rehder et Wilson. Sinomenine has been used for Rheumatoid arthritis as an anti-inflammatory and immunomodulative drugs. We have so far been investiga...
Thomas W Stief
Thomas W Stief
Background: Phospholipases A(2) (PLA(2)) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein-mediated contact phase of coagulation. The aim of the p...
Targeting receptors, transporters and site of absorption to improve oral drug delivery [0.03%]
针对受体、转运蛋白和吸收部位以改善口服药物递送
J H Hamman,P H Demana,E I Olivier
J H Hamman
Although the oral route of drug administration is the most acceptable way of self-medication with a high degree of patient compliance, the intestinal absorption of many drugs is severely hampered by different biological barriers. These barr...
Electrocardiographic findings in acutely and chronically T. cruzi-infected mice treated by a phenyl-substituted analogue of furamidine DB569 [0.03%]
T. cruzi感染急性及慢性期小鼠经芳基取代的抗虫剂DB569治疗后的心电图表现
Elen M de Souza,Gabriel M Oliveira,Maria de Nazaré C Soeiro
Elen M de Souza
Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. Recently we reported that a N-phenyl-substituted analogue of furamidine (DB569) exerts a micromolar trypanocidal acti...
Accelerators of osteogenesis by recombinant human bone morphogenetic protein-2 [0.03%]
重组人骨形态蛋白-2诱导成骨效应的加速器
Yasunori Okubo,Kenji Kusumoto,Kazuhisa Bessho
Yasunori Okubo
Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation. To evaluate the effect of basic fibroblast growth factor (bFGF), FK506, elca...
The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol [0.03%]
刺五加和五味子通过抑制压力激活蛋白激酶、一氧化氮以及皮质醇的增加来改变兔在应激状态下的反应
Alexander Panossian,Marina Hambardzumyan,Areg Hovhanissyan et al.
Alexander Panossian et al.
Adaptogens possess anti-fatigue and anti-stress activities that can increase mental and physical working performance against a background of fatigue or stress. The aim of the present study was to ascertain which mediators of stress response...
Modulation of visceral nociception, inflammation and gastric mucosal injury by cinnarizine [0.03%]
桂利嗪对内脏痛觉过敏、炎症及胃黏膜损伤的调节作用
Omar M E Abdel-Salam
Omar M E Abdel-Salam
The effect of cinnarizine, a drug used for the treatment of vertigo was assessed in animal models of visceral nociception, inflammation and gastric mucosal injury. Cinnarizine (1.25-20 mg/kg, s.c.) caused dose-dependent inhibition of the ab...
Effect of ribavirin alone or combined with silymarin on carbon tetrachloride induced hepatic damage in rats [0.03%]
利巴韦林或与水飞蓟素合用对四氯化碳致大鼠肝损伤的影响
Omar M E Abdel Salam,Amany A Sleem,Enayat A Omara et al.
Omar M E Abdel Salam et al.
The effect of the antiviral agent ribavirin given alone or in combination with silymarin on the development of liver injury induced in rats with carbon tetrachloride (CCl(4); 2.8 ml/kg followed by 1.4 ml/kg after one week) was studied. Riba...
Cyclophilin and viruses: cyclophilin as a cofactor for viral infection and possible anti-viral target [0.03%]
环孢菌素依赖型亲菌蛋白和病毒：亲菌蛋白作为病毒的辅助因子及其潜在抗病毒作用靶点
Koichi Watashi,Kunitada Shimotohno
Koichi Watashi
Cyclophilin (CyP) is a peptidyl prolyl cis/trans isomerase, catalyzing the cis-trans isomerization of proline residues in proteins. CyP plays key roles in several different aspects of cellular physiology including the immune response, trans...