Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design [0.03%]
查氏还原酶：抗锥体虫和抗利什曼原生动物药物设计的合理化学治疗靶点
M Omar F Khan
M Omar F Khan
Trypanosomiasis and leishmaniasis are two debilitating disease groups caused by parasites of Trypanosoma and Leishmania spp. and affecting millions of people worldwide. A brief outline of the potential targets for rational drug design again...
The relationship of arginine deprivation, argininosuccinate synthetase and cell death in melanoma [0.03%]
精氨酸剥夺、精氨琥珀酸合成酶在黑色素瘤细胞死亡中的关系研究
Niramol Savaraj,Chunjing Wu,Marcus Tien Kuo et al.
Niramol Savaraj et al.
It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death...
Endothelial dysfunction, erectile dysfunction and phosphodiesterase 5 inhibitors. An update of the current data and future perspectives [0.03%]
内皮功能障碍、勃起功能障碍和磷酸二酯酶-5抑制剂：当前数据及未来前景的更新报告
Angelis Konstantinopoulos,Konstantinos Giannitsas,Spiros Raptis et al.
Angelis Konstantinopoulos et al.
Endothelial dysfunction is a pathological entity that multiply affects the health status. Erectile dysfunction is being recognized as a condition that is strongly interrelated with endothelial dysfunction, being a vascular event itself. Ora...
Circulating vascular endothelial growth factor (VEGF) levels in advanced stage cancer patients compared to normal controls and diabetes mellitus patients with critical ischemia [0.03%]
晚期癌症患者与正常对照组和糖尿病重症缺血患者的循环血管内皮生长因子(VEGF)水平比较
Yoka H Kusumanto,Coby Meijer,Wendy Dam et al.
Yoka H Kusumanto et al.
Anti-angiogenic therapy is emerging as a valuable tool in the treatment of patients with cancer. As VEGF is a central target in anti-angiogenic therapy, its levels in the circulation might be relevant in selecting tumor types or patients li...
Cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions [0.03%]
青风藤碱的心血管药理作用及机械和电生理效应
Seiichiro Nishida,Hiroyasu Satoh
Seiichiro Nishida
Sinomenine is one of the alkaloids extracted from Chinese medical plant, Sinomenium acutum Rehder et Wilson. Sinomenine has been used for Rheumatoid arthritis as an anti-inflammatory and immunomodulative drugs. We have so far been investiga...
Thomas W Stief
Thomas W Stief
Background: Phospholipases A(2) (PLA(2)) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein-mediated contact phase of coagulation. The aim of the p...
Targeting receptors, transporters and site of absorption to improve oral drug delivery [0.03%]
针对受体、转运蛋白和吸收部位以改善口服药物递送
J H Hamman,P H Demana,E I Olivier
J H Hamman
Although the oral route of drug administration is the most acceptable way of self-medication with a high degree of patient compliance, the intestinal absorption of many drugs is severely hampered by different biological barriers. These barr...
Electrocardiographic findings in acutely and chronically T. cruzi-infected mice treated by a phenyl-substituted analogue of furamidine DB569 [0.03%]
T. cruzi感染急性及慢性期小鼠经芳基取代的抗虫剂DB569治疗后的心电图表现
Elen M de Souza,Gabriel M Oliveira,Maria de Nazaré C Soeiro
Elen M de Souza
Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. Recently we reported that a N-phenyl-substituted analogue of furamidine (DB569) exerts a micromolar trypanocidal acti...
Accelerators of osteogenesis by recombinant human bone morphogenetic protein-2 [0.03%]
重组人骨形态蛋白-2诱导成骨效应的加速器
Yasunori Okubo,Kenji Kusumoto,Kazuhisa Bessho
Yasunori Okubo
Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation. To evaluate the effect of basic fibroblast growth factor (bFGF), FK506, elca...
The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol [0.03%]
刺五加和五味子通过抑制压力激活蛋白激酶、一氧化氮以及皮质醇的增加来改变兔在应激状态下的反应
Alexander Panossian,Marina Hambardzumyan,Areg Hovhanissyan et al.
Alexander Panossian et al.
Adaptogens possess anti-fatigue and anti-stress activities that can increase mental and physical working performance against a background of fatigue or stress. The aim of the present study was to ascertain which mediators of stress response...