The relationship of arginine deprivation, argininosuccinate synthetase and cell death in melanoma
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It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death in melanoma but not... ...
