Photocontrolled immunotherapy: a BODIPY-caged MSA-2 for spatiotemporal activation of STING with visible light [0.03%]
基于BODIPY的时空光控STING激活免疫治疗分子前药研究
Karan Arora,Alexandra E Lee,Neil C Chada et al.
Karan Arora et al.
The STING pathway is a promising target for cancer immunotherapy, but systemic activation by small-molecule agonists can cause adverse effects. We report a visible light-activatable STING agonist, BODIPY-MSA-2, enabling precise, light-depen...
Quantification of foscarnet with chromogenic and fluorogenic chemosensors: indicator displacement assays based on metal ion coordination with a catechol ligand moiety [0.03%]
基于金属离子与邻苯二酚配体基团的配合物的指示剂置换法量化磷苯三酯：一种色度和荧光化学传感器方法
Ernestas Gaidamauskas,Debbie C Crans,Helen Parker et al.
Ernestas Gaidamauskas et al.
The catechol moiety in a chromophore was used in an indicator displacement assay for the chemosensing of the antiviral drug foscarnet (trisodium phosphonoformate, abbreviated as PFA). Applications of two methods were investigated, namely UV...
Doxorubicin and Iron-doped Mesoporous Silica Nanoparticles for Chemodynamic Therapy and Chemotherapy of Breast Cancer [0.03%]
用于乳腺癌化学动力学治疗和化疗的铁掺杂介孔硅纳米粒子及多柔比星研究
Le Tang,Mingjian Chen,Dan Wang et al.
Le Tang et al.
Breast cancer is one of the most prevalent malignancies, necessitating the exploration of more effective synergistic treatment strategies to overcome the limitations of conventional therapies. Chemodynamic therapy (CDT) is an innovative ant...
Malcolm T Ndlovu,Clare R Harding,Catherine H Kaschula et al.
Malcolm T Ndlovu et al.
Toxoplasmosis, a disease caused by the apicomplexan parasite Toxoplasma gondii, affects up to one third of the global population. Although immunocompetent individuals rarely experience severe symptoms, those with immunodeficiencies may pote...
Supramolecular assembly of phenanthrene-DNA conjugates into light-harvesting nanospheres [0.03%]
菲-dna缀合物超分子自组装构建光捕获纳米球体
Jan Thiede,Thomas Schneeberger,Ioan Iacovache et al.
Jan Thiede et al.
The self-assembly of highly functionalized phenanthrene-DNA conjugates into supramolecular nanostructures is presented. DNA oligomers modified with phenanthrene residues at the 3'-end and internal positions self-assemble into spherical nano...
A colorimetric approach for monitoring the reduction of platinum(iv) complexes in aqueous solution [0.03%]
一种监测水溶液中铂(IV)配合物还原反应的比色方法
Shitong Huang,Jevon W Marsh,Jhanelle R G White et al.
Shitong Huang et al.
We report the synthesis of 4-nitrophenyl (4-NP) functionalised Pt(iv) complexes as a colorimetric strategy for monitoring Pt(iv) reduction in aqueous solution. Treatment of each 4-NP functionalised Pt(iv) complex with the biological reducta...
One-pot hydrothermal synthesis of FeNbO4 microspheres for effective sonocatalysis [0.03%]
用于有效超声催化的FeNbO4微球的一锅水热合成法
Min He,Defa Li,Yu Liu et al.
Min He et al.
FeNbO4 sonocatalysts were successfully synthesized by a simple hydrothermal route at pH values of 3, 5, 7, 9 and 11. The catalysts were characterized by XRD, XPS, TEM, SEM, N2 adsorption and DRS to analyse the effect of pH parameters on the...
Regiodivergent sulfonylation of terminal olefins via dearomative rearrangement [0.03%]
通过去芳构化重排实现Terminal olefins的区域特异性磺酰化反应
Ever A Blé-González,Stephen R Isbel,Olatunji S Ojo et al.
Ever A Blé-González et al.
Sulfones are fascinating and highly used functional groups, but current syntheses still have limitations. Here, a regiodivergent transition metal-free approach towards sulfones [(E)-allylic sulfones and α-sulfonyl-methyl styrenes] is repor...
Solid-state growth of Ag nanowires and analysis of the self-growing process on a bio-polymer chitosan film [0.03%]
固相银纳米线的生长及生物聚合物壳聚糖薄膜上的自生长过程分析
Harish Chevva,Rakkiyappan Chandran,Dennis LaJeunesse et al.
Harish Chevva et al.
The growth mechanism of silver nanowires (AgNWs) in solution has been thoroughly investigated and it has been demonstrated that factors like oxidative etching and inclusion of Cl- ions in the reaction system play critical roles in the forma...
Komal Chillar,Adikari M D N Eriyagama,Yipeng Yin et al.
Komal Chillar et al.
Over a hundred non-canonical nucleotides have been found in DNA and RNA. Many of them are sensitive toward nucleophiles. Because known oligonucleotide synthesis technologies require nucleophilic conditions for deprotection, currently there ...