Is there a role of calcitonin gene-related peptide in cortical spreading depression mechanisms?- Argument pro [0.03%]
降钙素基因相关肽在皮质扩散性抑制机制中的作用？——支持观点
Marina Romozzi,Paolo Calabresi
Marina Romozzi
Migraine and increased cardiovascular disease risk: interaction with traditional risk factors and lifestyle factors [0.03%]
偏头痛与心血管疾病风险增加：传统危险因素和生活方式因素的交互作用
Ying Huang,Wen Yan,Yifan Jia et al.
Ying Huang et al.
Background: Migraine has been linked to a heightened risk of cardiovascular disease, and acute treatment drugs, such as triptans, might increase this risk. This study aimed to determine whether the elevated cardiovascular...
Beyond the "string of beads": case-based exploration of diagnostic pitfalls and solutions in reversible cerebral vasoconstriction syndrome [0.03%]
“珠子串”之外：可逆性脑血管收缩综合征的诊断陷阱及对策——病例分析
Seung Ae Kim,Eung Yeop Kim,Shuu-Jiun Wang et al.
Seung Ae Kim et al.
Background: The diagnosis of reversible cerebral vasoconstriction syndrome (RCVS) is challenging due to its varied clinical manifestations and imaging findings. While it typically presents with a sudden, severe thundercla...
Increased infection risk in patients on preventive CGRP-targeting therapies- a meta-analysis and clinical effect assessment [0.03%]
一项针对预防性CGRP靶向治疗患者的感染风险增加的meta分析和临床影响评估
Marcin Straburzyński,Daria Kopyt,Karol Marschollek et al.
Marcin Straburzyński et al.
Background: Calcitonin gene related peptide (CGRP) pathway targeting therapies have proven efficacy, safety and tolerability. However, CGRP is also involved in immune responses, and reports of an increased risk of infecti...
Plasma SuPAR and therapeutic response to erenumab in migraine: a REFORM study [0.03%]
血浆可溶性尿激酶型纤溶酶原激活物受体与偏头痛患者依瑞来珠单抗治疗反应关系的前瞻性研究（REFORM研究）
William K Karlsson,Rune H Christensen,Haidar M Al-Khazali et al.
William K Karlsson et al.
Background: Soluble urokinase-plasminogen activator receptor (suPAR) is a biomarker of systemic inflammation and elevated in plasma of individuals with migraine with aura. As inflammatory cytokines can upregulate calciton...
Transient focal neurological symptoms and headache: is it TIA or migraine with aura? [0.03%]
一过性神经功能缺损和头痛：是短暂性脑缺血发作还是伴有先兆的偏头痛？
Elena R Lebedeva,Jes Olesen
Elena R Lebedeva
Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression [0.03%]
通过AKU- 005抑制内源大麻素水解酶MAGL，FAAH和ABHD6减少皮质扩散性抑郁
Flavia Brugia,Konstantin Ivanov,Auni Aroviita et al.
Flavia Brugia et al.
Background: Migraine is a common neurovascular disorder that remains currently untreated in half of the patients. One third of migraine patients experience aura, which is associated with the development of cortical spread...
Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice [0.03%]
通过单酰甘油脂酶抑制增强内源大麻素系统可缓解小鼠偏头痛相关性疼痛
Elizaveta Mangutov,Yaseen Awad-Igbaria,Kendra Siegersma et al.
Elizaveta Mangutov et al.
Background: Migraine affects over 1 billion people worldwide and is a leading cause of disability. Targeting the cannabinoid system offers a promising approach for pain and migraine relief. This study evaluated a novel mo...
Adoption of rimegepant in Denmark: a register-based study on uptake, prescribing patterns and initiator characteristics [0.03%]
丹麦受理美加普坦用药情况研究：基于注册表的用药率、处方模式和初始使用者特征分析
Lanfranco Pellesi,Thien Phu Do,Martin Thomsen Ernst et al.
Lanfranco Pellesi et al.
Background: Rimegepant, an oral calcitonin gene-related peptide (CGRP) receptor antagonist, is the first drug within its class approved for both acute and preventive treatment of migraine. This study examines its uptake i...
The association between endometriosis and migraine: a systematic review and meta-analysis of observational studies [0.03%]
子宫内膜异位症和偏头痛之间的关联：观察性研究的系统评价和荟萃分析
Giorgia Elisabeth Colombo,Sofia Makieva,Edgardo Somigliana et al.
Giorgia Elisabeth Colombo et al.
Background: Endometriosis affects women of reproductive age. Increasing attention is being given to the characterization of comorbidities in endometriosis to enhance clinical phenotyping. Among these comorbidities, migrai...