Headache disorders and the Global Burden of Disease study: deficiencies, challenges and opportunities for betterment [0.03%]
头痛疾患与全球疾病负担研究：缺陷、挑战及改进的机会
Andreas Kattem Husøy,Latifa Adarmouch,Amalie Berring-Uldum et al.
Andreas Kattem Husøy et al.
Evaluating clinical associations of immediate post-traumatic headache: a prospective multicenter study [0.03%]
一项前瞻性多中心研究：评估即时创伤后头痛的临床相关性
Mansoureh Togha,Maryam Bahreini,Sepideh Aarabi et al.
Mansoureh Togha et al.
Background: Post-traumatic headache (PTH) is a frequent early consequence of head traumatic injury, yet emergency departments (EDs) lack practical tools to identify high-risk patients. Whether routinely documented trauma ...
Observational Study
The journal of headache and pain. 2026 Aug 6;27(1):201. DOI:10.1186/s10194-026-02478-w 2026
Genome-wide association susceptibility loci for cluster headache support a role for inflammation in the pathophysiology [0.03%]
全基因组关联易感位点的群集性头痛支持炎症在病理生理学中的作用
Caroline Ran,Clémence Deborgies Sanches,Julia Swedblom et al.
Caroline Ran et al.
Background: Recent genetic findings have broadened the perspectives of cluster headache pathophysiology. Genes identified by genome wide association studies are likely to be involved in the pathophysiological mechanisms u...
Impact of semaglutide introduction on the use of triptans: an interrupted-time series [0.03%]
司美格鲁肽引入对曲普坦使用的影响：一项中断时间序列研究
Noémie Roland,Heidi Sonne,Lanfranco Pellesi et al.
Noémie Roland et al.
Background: Emerging evidence suggests that glucagon-like peptide-1 receptor agonist (GLP-1RA) may be associated with reduced migraine burden. We aimed to evaluate whether semaglutide for weight management initiation is a...
Exploratory Ising model network analysis of cluster headache: mapping conditional associations across symptoms, triggers, and pain localization [0.03%]
探索性伊辛模型网络分析丛集性头痛：绘制症状、触发因素和疼痛定位之间的条件关联地图
Mansoureh Togha,Omid Kohandel Gargari,Fariborz Khorvash et al.
Mansoureh Togha et al.
Background: Cluster headache (CH) is a rare and disabling primary headache disorder characterized by severe unilateral pain and cranial autonomic symptoms. Although its diagnostic criteria are well defined, the conditiona...
Twelve-months prospective real-world assessment of effectiveness and safety of eptinezumab in migraine patients difficult-to-treat and naïve to CGRP monoclonal antibodies: results of the French FHU INOVPAIN registry [0.03%]
法国FHU INOVPAIN登记处难治性偏头痛和CGRP单克隆抗体初治的偏头痛患者中Eptinezumab有效性和安全性的前瞻性真实世界一年评估结果分析
S Ferrao-Malheiro,R Fabre,T Jiacomini et al.
S Ferrao-Malheiro et al.
Background: Randomized clinical trials have demonstrated the efficacy and safety of eptinezumab. The aim of this study was to evaluate the effectiveness and safety of eptinezumab in a real-world setting among patients wit...
Interictal burden in migraine: a systematic review of conceptual domains and measurement properties of instruments [0.03%]
偏头痛间期负担的系统性综述：概念领域和测量工具属性
Cornelius Angerhöfer,Yutaro Fuse,Samuel Van Langenhove et al.
Cornelius Angerhöfer et al.
Background: Migraine imposes significant burden not only during acute attacks but also during headache-free interictal periods. Several patient-reported outcome measures (PROMs) have been used to assess this interictal bu...
Tear fluid Calcitonin gene-related peptide in patients with idiopathic intracranial hypertension headache - a prospective case-control study [0.03%]
原发性颅内高压患者头痛相关的 Tears液降钙素基因相关肽测定-前瞻性病例对照研究
Cem Thunstedt,Ad Shehi,Ozan E Eren et al.
Cem Thunstedt et al.
Background: Headache is the most common symptom of idiopathic intracranial hypertension (IIH) and may persist despite therapy, with a significant impact on quality of life. Since calcitonin gene-related peptide (CGRP) pla...
Normative structural MRI deviation factors summarize patient-level neuroanatomical heterogeneity across episodic and chronic migraine [0.03%]
规范性结构MRI偏差因素概述了不同发作性和慢性偏头痛患者的神经解剖异质性
Chenyu Dai,Mengqian Ye,Xinhao Li et al.
Chenyu Dai et al.
Background: Structural MRI findings in migraine are inconsistent across cohorts, suggesting that group contrasts may obscure patient-level heterogeneity. We tested whether individualized normative structural deviations co...
Genetic regulation of cell type-specific chromatin accessibility contributes to migraine etiology [0.03%]
基因调控的染色质可访问性影响细胞类型特异性，有助于偏头痛的发生机制
Qiuhan Xu,Zhaohui Chai,Yuning Zhang et al.
Qiuhan Xu et al.
Background: Migraine is a common and disabling neurological disorder, yet most causal regulatory variants and their target cell types remain unresolved. Disease-associated variants are enriched in non-coding cis-regulator...