Peptide Mapping Using Multienzyme Digestion Strategies Integrated with LC-HRMS Workflow: A Case Study [0.03%]
基于LC-HRMS的工作流程进行多酶消化策略肽图分析：以临床样本为例
Deep Maheshwari,Devendra Badgujar,Gulshan Kumar et al.
Deep Maheshwari et al.
Peptide therapeutics are becoming an increasingly important class of pharmaceuticals due to their attractive therapeutic properties. However, their development remains challenging because of inherent structural complexity, requiring advance...
Improvement of Analysis and Transferability in Peptide Purification: From HPLC to FPLC and Back Again [0.03%]
肽纯化分析和普适性的改进：从HPLC到FPLC再回到HPLC
Alessandro Streuli,Vanessa Erckes,Brunello Nardone et al.
Alessandro Streuli et al.
Optimal purification, high purity and robust purity control for synthetic peptides are critical, as even minor impurities can alter biological activity, distort analytical results and compromise downstream applications. Reliable translation...
Covalent Peptide-Based N-Myc/Aurora-A Inhibitors Bearing Sulfonyl Fluoride Warheads [0.03%]
带有磺酰氟战头的共价肽基N-Myc / Aurora-A抑制剂
Robert S Dawber,Diana Gimenez,George W Preston et al.
Robert S Dawber et al.
Orthosteric inhibition of the N-Myc/Aurora-A protein-protein interaction (PPI) represents a potential mechanism by which degradation of N-Myc can be induced, given its interaction with Aurora-A competes with the factors that tag it for prot...
Bismuth Bicycles [0.03%]
铋自行车
Saan Voss,Amin Sagar,Arnaud Tiberghien et al.
Saan Voss et al.
Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules. Phage-encoded libraries of bicyclic peptides enable the discovery of h...
Identification of Human Bone Morphogenetic Protein-2 Elbow Epitope as Its Coreceptor Recognition Site and Design of Elbow-Derived Hairpin Peptides to Specifically Target the Coreceptor [0.03%]
人骨形态生成蛋白-2肘部表位作为其辅受体识别位点的鉴定及设计靶向该辅受体的肽类化合物
Yan Xu,Tianming Pan,Jinpeng Hong
Yan Xu
Human bone morphogenetic protein-2 (BMP2) is an effective osteoinductor in bone formation and growth via binding to its cognate receptors and coreceptors. Traditionally, the protein is identified to possess a conformational wrist epitope an...
Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides [0.03%]
让空白的脸表达出来：修改化学惰性肽的化学方法
Yoshitaka Moriyama,Hikari Sada,Takeshi Nanjo
Yoshitaka Moriyama
Very minor structural modifications in peptides can result in significant changes in their function. To obtain analogues with such small structural but big functional differences compared to the original peptides, amino acid monomers are us...
An Effective Method for Isolating Ergothioneine Analogues for Use in Peptide Synthesis: 2-Thiohistidine and Fmoc-2-Thiohistidine [0.03%]
一种用于肽合成的拟 ergothioneine 类化合物的制备方法：2-硫代组氨酰和Fmoc-2-硫代组氨酰的分离纯化及表征研究
Quinn A Bennett,Matthew Chien,Erik L Ruggles et al.
Quinn A Bennett et al.
Here, we report on an improved synthesis of the novel amino acid 2-thiohistidine and its Fmoc-derivative through the addition of sodium chloride to the isolation steps of each synthetic procedure. These compounds must be synthesized in eith...
Turn-Induction in Peptides Incorporating Novel Cyrene-Derived α,α-Disubstituted Amino Acid [0.03%]
含新型Cyrene衍生物α,α-双取代氨基酸肽的翻转诱导研究
Kajumee Bora Bhowal,Raphael Hitti,William D Lubell
Kajumee Bora Bhowal
Cyrene-derived α,α-disubstituted amino acids (H-Cyr-OH) are introduced into peptides using the multiple component Ugi reaction. Conformational analysis of the Cyr monomer and dimer was performed by X-ray crystallography and NMR spectrosco...
A Novel Cell-Penetrating Lipopeptide for DNA Binding, Self-Assembly, and Delivery Into HeLa and Pluripotent Stem Cells [0.03%]
一种新的细胞穿透脂肽，可结合DNA、自我组装并进入HeLa和多能干细胞中
Lucas R de Mello,Tâmisa Seeko Bandeira Honda,Valeria Castelletto et al.
Lucas R de Mello et al.
A lipopeptide is designed that contains an epitope from simian virus T-antigen (SV40T, PKKKRKV) conjugated to an N-terminal palmitoyl (C16-) moiety, with the aim to act as an effective cell-penetrating lipopeptide, with additional aggregati...
Emerging Therapies in Metabolic Health: A Comprehensive Review of GLP-1, GIP, and Glucagon Agonists [0.03%]
代谢健康新兴疗法：GLP-1、GIP和胰高血糖素激动剂的全面综述
Mohammed Shareef Khan,Utkarsh Bhutani,Hariharan Venugopal et al.
Mohammed Shareef Khan et al.
Incretin-based therapies have become central to type 2 diabetes (T2D) management, offering benefits beyond glycemic control, including weight reduction, cardiovascular protection, and emerging roles in renal and neurological health. This re...