Radiolabeled Angiopep-2 Peptide Vector as a Preclinical Platform for Blood-Brain Barrier Targeting: Synthesis, Radiolabeling, and Preliminary In Vivo Biodistribution in Mice [0.03%]
放射标记的Angiopep-2肽载体作为针对血脑屏障的小动物脑靶向平台：合成，标记及初步体内分布研究
Evgenia Fotou,Adamantia Apostolopoulou,Christina-Georgia Bika et al.
Evgenia Fotou et al.
Brain tumor therapy remains limited by the blood-brain barrier (BBB), which restricts drug access. BBB-penetrating peptides offer a promising strategy for delivering therapeutic and diagnostic payloads. Angiopep-2 is a well-established vect...
Thania Hammoum,Karidia Konate,Yannick Mousli et al.
Thania Hammoum et al.
Peptide-based nanoparticles (PBN) have emerged as a promising alternative to lipid nanoparticles (LNP) for nucleic acid delivery and efficient cellular uptake. In this study, we evaluated the formulation of WRAP5 (W- and R-rich amphipathic ...
A Single Hydrophobic Residue Enhances the Uptake of Short Cationic Proline-Rich Cell-Penetrating Peptides [0.03%]
一个疏水残基能够增强短的富含脯氨酸的阳离子穿膜肽的胞吞作用
Adeline Schmitt,Helma Wennemers
Adeline Schmitt
Cationic cell-penetrating peptides (CPPs) are a versatile platform for intracellular cargo delivery into mammalian cells but often suffer from low cellular uptake and endosomal entrapment. Here, we investigated the effect of a single cycloh...
Mechanistic Evidence for Gold(III)-Mediated Arylation of the Cys-Sec Motif of Thioredoxin Reductase 1 [0.03%]
硫氧还蛋白还原酶1中的Cys-Sec基序的金（III）介导的芳构化作用机制证据
Ioannis Kanavos,Douglas H Nakahata,Luigi Messori et al.
Ioannis Kanavos et al.
Thioredoxin reductase (TrxR) is a well-known target for gold-based drugs, which typically behave as strong inhibitors of this selenoenzyme. Despite recent evidence that cyclometalated Au(III) complexes inhibit TrxR1 and arylate cysteine (Cy...
Protein and Peptide Inhibitors of Mineralization: A Systematic Review of In Vitro Studies [0.03%]
体外研究系统综述：蛋白质和肽类矿化抑制剂
Alberto Mimila-Cortes,Lucia Méndez-Sánchez,Luis Fernando Ramírez-González et al.
Alberto Mimila-Cortes et al.
Biomineralization is regulated by interactions between inorganic phases and biological macromolecules. Peptides derived from mineral-associated proteins are key modulators due to their ability to bind crystal nuclei and mineral surfaces. Ho...
Structure-Guided Engineering of Histidine-Rich pH-Switchable Endosomolytic Peptides for Spleen-Selective siRNA Delivery to Inflammatory Macrophages [0.03%]
基于结构导向组氨酸富集型pH值依赖裂解囊泡肽的工程化设计用于脾脏选择性siRNA沉默炎症巨噬细胞(skb1.0)
Dilpreet Singh
Dilpreet Singh
Extrahepatic delivery of small interfering RNA (siRNA) remains a major translational challenge because most nanocarriers preferentially accumulate in the liver, while endosomal sequestration limits productive cytosolic release. Inflammatory...
Protection of SARS-CoV-2 Infection by Targeting Viral Spike Protein With De Novo Designed ACE2-Derived Undecapeptide [0.03%]
利用ACE2衍生的全新设计的十一肽针对新冠病毒刺突蛋白进行防护
Anindya Dutta,Nilanjan Banerjee,Soushruti Sarkar et al.
Anindya Dutta et al.
The envelope-anchored trimeric spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates the attachment and entry of the virus within human cells by utilizing the angiotensin converting enzyme 2 (ACE2) as a rece...
Clustering of Spin-Labeled Molecules in Membranes: What Information Can Be Obtained From Electron-Electron Double Resonance [0.03%]
自旋标记分子在膜中的聚集从电子双共振实验可以获得什么信息
Sergei A Dzuba
Sergei A Dzuba
Clustering of antimicrobial peptides (AMPs) in bacterial membranes is a key step in the formation of nanoscale pores within them, which may underlie their bactericidal action. Double electron-electron resonance (DEER, also known as PELDOR) ...
Organogelation to Hydrogelation: Effect of C-Terminal Functionalization of Peptides [0.03%]
从有机凝胶到水凝胶：肽C末端官能团化的影响
Sumedha Gupta,Nikita Jain,Ramesh Ramapanicker
Sumedha Gupta
Peptide-based self-assembled gels are promising soft materials and have applications in biomedicine and material science. While the effect of the substituents on the N-terminal protecting group on the gelation behavior of peptides is often ...
Identification and Mechanistic Study of a Novel Keap1-Targeting Antioxidant Peptide From Ulva prolifera Protein [0.03%]
从海藻中鉴定并研究一种新型的Keap1靶向抗氧化肽及其机制研究
Shaohui Zhu,Shanglian Liu,Huashan Yao et al.
Shaohui Zhu et al.
Activating Nrf2 by targeting the Keap1-Nrf2 signaling axis has emerged as a viable therapeutic approach for managing oxidative stress and its associated disorders. This study employed virtual digestion, ADMET profiling, and molecular dockin...