No Significant Secondary Structural Change of α-Synuclein Monomer by Site-Specific DOPA or Phosphorylation Introduction in Its C-Terminal Region [0.03%]
在α-突触核蛋白C端区域特定位点引入多巴或磷酸化后单体的二级结构未发生显著变化
Tatsuhito Matsuo,Isao Suetake,Mariko Kimura et al.
Tatsuhito Matsuo et al.
α-Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease. Among the various posttranslational modifications of αSyn, several have been implicated in the degene...
William D Lubell,John D Wade,Paolo Rovero
William D Lubell
Peptide Therapeutics for Solid Tumors: Functional Classes, AI-Enhanced Discovery and Clinical Advances [0.03%]
肽类肿瘤治疗药物：功能类型、人工智能增强发现和临床进展
Jinqiu Liang,Xiaochuan Tang,Haoqi Li et al.
Jinqiu Liang et al.
Solid tumors, the most prevalent form of malignancy, pose therapeutic challenges distinct from hematologic malignancies due to their complex biology, including high tumor heterogeneity, a dense extracellular matrix (ECM), an immunosuppressi...
Gold Nanoparticles Coated With the Antimicrobial Peptide Os-C(W5): Anticandidal and Biological Activity [0.03%]
覆盖抗微生物肽Os-C(W5)的金纳米颗粒的抗菌和生物活性研究
P J Palm,R R Chirombo,C K Chiramba et al.
P J Palm et al.
Candida albicans is a critical-priority fungal pathogen due to its global burden of infection, biofilm-forming ability, and increasing drug resistance. Previously, the tick-derived antimicrobial peptide (AMP), Os-C, demonstrated antifungal,...
Peptide Conformational Determination With Vibrational Circular Dichroism and Isotope Labeling: Focused Review of 310-Helical Peptide Spectroscopic Structural Studies [0.03%]
基于圆二色谱同位素标记的肽类构象确定：310-螺旋肽光谱结构研究综述
Timothy A Keiderling
Timothy A Keiderling
Optical spectroscopic techniques have long been used to determine average secondary structure in proteins and peptides, but these are primarily limited to determination of relative sheet and helix content, with the remainder often designate...
Edge-Grafted Polyarginine Functionalization of Graphene Nanocarriers Maintains Noncovalent Aromatic Drug Loading [0.03%]
边缘嫁接的聚精氨酸功能化石墨烯纳米载体保持非共价芳香药物负载能力
Beatrice Scagnoli,Alessandro Semeraro,Kaiyue Hu et al.
Beatrice Scagnoli et al.
Covalent peptide grafting is widely used to improve the biological performance of nanocarriers, especially through cell-penetrating peptides (CPPs) that enhance cellular uptake. However, when drug loading relies on noncovalent interactions,...
Apolipoprotein A-I as a Molecular Target of the Immunomodulatory Peptide Jusvinza: Mechanistic Insights From Affinity and In Silico Studies [0.03%]
免疫调节肽Jusvinza作用于载脂蛋白A-I的分子机制及亲和力和分子对接研究
Camila Viviana Rosales,Mabel Hernández Cedeño,Glay Chinea et al.
Camila Viviana Rosales et al.
Jusvinza is an immunomodulatory pharmaceutical drug developed for the treatment of rheumatoid arthritis. Its active ingredient is an altered peptide ligand-derived from a T-cell epitope of the human 60-kDa heat shock protein-referred to as ...
Integrative Identification of Anti-Photoaging Peptides From Stress-Tolerant Microorganisms via Machine Learning and KEAP1-NRF2 Docking [0.03%]
基于机器学习和KEAP1-NRF2对接的耐逆微生物抗光老化肽组研究
Hanui Lee,Gyeong Han Jeong,Ji Wan Choi et al.
Hanui Lee et al.
Excess reactive oxygen species generated by ultraviolet exposure cause photoaging by degrading collagen and inhibiting its synthesis. This study presents a comprehensive strategy connecting the biological stress responses of γ-irradiated m...
Cementum Attachment Protein-Derived Peptides Modulate Brushite and Calcium Oxalate Crystallization In Vitro [0.03%]
钙质和草酸钙结晶的调节因子：牙骨质结合蛋白片段体外研究
Alberto Mimila-Cortes,Jesús Arenas-Alatorre,Karina Jiménez-Duran et al.
Alberto Mimila-Cortes et al.
Pathological mineralization involves the uncontrolled crystallization of calcium phosphate (brushite) and calcium oxalate, leading to renal calculi and ectopic calcifications. Peptides enriched in acidic or phosphorylated residues are poten...
Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides [0.03%]
阳离子五肽脂肽的纳米结构及其促胶原蛋白合成作用
Lucas R de Mello,Valeria Castelletto,Jani Seitsonen et al.
Lucas R de Mello et al.
The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C16-KTTKS and a variant with arginine substitution for lysine, C16-RTTRS, are investigated. C16-KTTKS is known commercially as Matrixyl and is...