Preeclampsia Diagnosis Using β-Hairpin Peptide for ELABELA Detection [0.03%]
用于检测ELABELA的β发夹肽的子痫前期诊断
Behafarid Ghalandari,Jessica Jessica,Qiang Zhang et al.
Behafarid Ghalandari et al.
Preeclampsia (PE) poses risks to mothers and infants, especially in low-resource settings. Diagnosis of PE is difficult due to nonspecific symptoms and limited biomarker screening. ELABELA, a circulating peptide hormone and endogenous ligan...
Fluctuating β-Sheet Secondary Structure in DS119 Explains the Small Effects of Backbone N-Amination on Thermal Stability [0.03%]
DS119中波动的β-折叠二级结构解释了主链N-氨基化对热稳定性的小影响
Yushi Qiao,Syrah K Starnes,Jožica Dolenc et al.
Yushi Qiao et al.
The miniprotein DS119 has been used as a model system to probe the effects of introducing residues with backbone N-amination into a region of parallel β-sheet secondary structure. Derivatives featuring backbone N-methylation have also been...
Influence of Peptide-Based Chelator Sequences on HER2-Targeting Radiopeptide [0.03%]
基于肽的螯合序列对HER2靶向放射性药物的影响
Sonal Gupta,Manoj Kumar,Krishna Mohan Repaka et al.
Sonal Gupta et al.
In our pursuit of developing HER2-targeting radiolabeled peptides for detection and therapy of HER2-positive breast cancer, the previously reported rL-A9 peptide had shown promising potential. In the present work, a different variant of rL-...
From Venom-to-Vial-to-Pill: The Translational Journey of GLP-1 Peptides and the Evolving Landscape of Biopharmaceutics Modeling [0.03%]
从毒液到小瓶到药片：GLP-1肽的转化之旅及生物药剂学建模的演变景观
Muzaffaruddin Ahmed Madny,Aditya Murthy
Muzaffaruddin Ahmed Madny
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become an important therapeutic option for metabolic disorders. Their development, from the early identification of exendin-4 in Gila-monster venom to the creation of long-acting ana...
Oral Peptide Nano-Formulations for Breast Cancer: An Enhancer-Centric, Regulatory-Ready Path to Clinical Translation [0.03%]
乳腺癌口服肽纳米配方：一个以增强剂为中心且符合监管要求的临床转化路径
Dilpreet Singh,Bishal Singh,Pooja A Chawla et al.
Dilpreet Singh et al.
Breast cancer is increasingly managed as a long-term condition, intensifying the need for therapies that are effective, tolerable, and suitable for chronic administration. Peptide-based therapeutics offer high molecular specificity and favo...
Peptide Mapping Using Multienzyme Digestion Strategies Integrated with LC-HRMS Workflow: A Case Study [0.03%]
基于LC-HRMS的工作流程进行多酶消化策略肽图分析：以临床样本为例
Deep Maheshwari,Devendra Badgujar,Gulshan Kumar et al.
Deep Maheshwari et al.
Peptide therapeutics are becoming an increasingly important class of pharmaceuticals due to their attractive therapeutic properties. However, their development remains challenging because of inherent structural complexity, requiring advance...
Improvement of Analysis and Transferability in Peptide Purification: From HPLC to FPLC and Back Again [0.03%]
肽纯化分析和普适性的改进：从HPLC到FPLC再回到HPLC
Alessandro Streuli,Vanessa Erckes,Brunello Nardone et al.
Alessandro Streuli et al.
Optimal purification, high purity and robust purity control for synthetic peptides are critical, as even minor impurities can alter biological activity, distort analytical results and compromise downstream applications. Reliable translation...
Covalent Peptide-Based N-Myc/Aurora-A Inhibitors Bearing Sulfonyl Fluoride Warheads [0.03%]
带有磺酰氟战头的共价肽基N-Myc / Aurora-A抑制剂
Robert S Dawber,Diana Gimenez,George W Preston et al.
Robert S Dawber et al.
Orthosteric inhibition of the N-Myc/Aurora-A protein-protein interaction (PPI) represents a potential mechanism by which degradation of N-Myc can be induced, given its interaction with Aurora-A competes with the factors that tag it for prot...
Bismuth Bicycles [0.03%]
铋自行车
Saan Voss,Amin Sagar,Arnaud Tiberghien et al.
Saan Voss et al.
Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules. Phage-encoded libraries of bicyclic peptides enable the discovery of h...
Identification of Human Bone Morphogenetic Protein-2 Elbow Epitope as Its Coreceptor Recognition Site and Design of Elbow-Derived Hairpin Peptides to Specifically Target the Coreceptor [0.03%]
人骨形态生成蛋白-2肘部表位作为其辅受体识别位点的鉴定及设计靶向该辅受体的肽类化合物
Yan Xu,Tianming Pan,Jinpeng Hong
Yan Xu
Human bone morphogenetic protein-2 (BMP2) is an effective osteoinductor in bone formation and growth via binding to its cognate receptors and coreceptors. Traditionally, the protein is identified to possess a conformational wrist epitope an...