Turn-Induction in Peptides Incorporating Novel Cyrene-Derived α,α-Disubstituted Amino Acid
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Cyrene-derived α,α-disubstituted amino acids (H-Cyr-OH) are introduced into peptides using the multiple component Ugi reaction. Conformational analysis of the Cyr monomer and dimer was performed by X-ray crystallography and NMR spectroscopy. In the solid sta... ...