Aditi Swamy,Karishma Ravikumar,Merlin Pious et al.
Aditi Swamy et al.
The tumor microenvironment (TME) is a complex ecosystem composed of cancer cells, stromal components, immune infiltrates, and neural elements. The presence and growth of nerves within or in close association with tumor tissue, a phenomenon ...
Endoplasmic Reticulum Stress Exacerbates Nucleus Pulposus Cell Pyroptosis via PERK-Dependent Activation of JAK1-STAT3 Signaling [0.03%]
内质网应激通过PERK依赖的JAK1-STAT3信号激活促进椎间盘髓核细胞焦亡
Lu Chen,Zi-Jian Zhang,Yuan-Peng Li et al.
Lu Chen et al.
Endoplasmic reticulum stress (ERS) has been implicated in the pathophysiology of intervertebral disc degeneration (IDD), yet the precise molecular mechanisms linking excessive ERS to pyroptotic cell death in nucleus pulposus cells (NPCs) re...
Cytoskeletal Remodeling by Oncoviruses: A Key Factor in Tumor Invasion and Metastasisa [0.03%]
致癌病毒引发的细胞骨架重排：肿瘤侵袭和转移的关键因素
Yue Liu,Yan Zhang,Wen Liu
Yue Liu
Tumor invasion and metastasis, the leading causes of cancer-related mortality, are critically driven by cytoskeletal remodeling, a process extensively hijacked by oncoviruses to promote malignant progression. This review comprehensively exa...
APOA1 as a Potential Therapeutic Target and Novel Biomarker in Lung Adenocarcinoma [0.03%]
APOA1作为肺癌腺癌治疗靶点和新型生物标志物的潜力研究
Yuening Sun,Jie Shen,Yizhou Lin et al.
Yuening Sun et al.
Apolipoprotein A1 (APOA1), the main structural protein of high-density lipoprotein, has been implicated in cancer, but its role in lung adenocarcinoma (LUAD) remains unclear. Here, we integrate pan-cancer and LUAD-focused multi-omics with p...
SENP3 Promotes Hepatocyte Steatosis via De-SUMOylation of SREBP2 [0.03%]
SENP3通过去SUMO化SREBP2促进肝细胞脂肪变性
Qianyu Tang,Wenjing Peng,Xiaohua Jiang et al.
Qianyu Tang et al.
SENP3, a member of the sentrin-specific protease family, plays a pivotal role in lipid metabolism and the pathogenesis of fatty liver disease by regulating the dynamic process of SUMOylation. It has previously been demonstrated that SREBP2 ...
Yueyou Wang,Jingyuan Wang,Han Li et al.
Yueyou Wang et al.
Cancer immunotherapy, focusing on breaking tumor microenvironment (TME) immunosuppression, is limited by heterogeneity and drug resistance. Exosomes, 30-150 nm extracellular vesicles(EVs) carrying proteins, lipids, and noncoding RNAs, media...
Andrea G Marshall,Dominique Stephens,Kit Neikirk et al.
Andrea G Marshall et al.
Alzheimer's Disease (AD) is a global health issue, affecting over 6 million people in the United States, with that number expected to increase as the population ages. As a neurodegenerative disorder that affects memory and cognitive functio...
A MARCKS Effector Domain-Derived Cytotoxic Peptide Induces Acute Tumor Cell Death [0.03%]
一种MARCKS效应子结构域衍生的细胞毒性肽可诱导肿瘤急性细胞死亡
Yucai Wang,Yue Qiu,Decheng Liu et al.
Yucai Wang et al.
Peptide drugs, with their unique properties of specific therapeutic effects and minimal side effects, are a promising avenue in cancer treatment. The MARCKS effector domain (ED) peptide has been found to inhibit MARCKS function or induce ce...
Lean Metabolic Dysfunction-Associated Steatotic Liver Disease: A Wolf in Sheep's Clothing [0.03%]
狼在羊群中的代谢功能障碍相关性脂肪肝疾病
Xixi Fang,Chenhao Xu,Jun Lu et al.
Xixi Fang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32.4% of the global population. It is expected to be the primary cause of end-stage liver disease and liver transplantation. Obesity is a major risk fact...
Antitumoral Effects of Fungal Natural Products on Chronic Myeloid Leukemia Models: What Do We Know so Far? [0.03%]
菌类天然产物抗白血病慢性髓系 leukemia的作用机制及其进展
Julya Emmanuela de Andrade Vieira,Jessica Gotardi,Alexandre José Macedo et al.
Julya Emmanuela de Andrade Vieira et al.
CML is a myeloproliferative disease related to several cases of resistance and intolerance to treatments; therefore, the search for new therapeutic agents in natural products has become increasingly important. The chemical diversity and bio...