Cyclooxygenase-2 Inhibition and Anti-Platelet Aggregation Activity of Astaxanthin-Hydrogel in Comparison to Celecoxib Against Rheumatoid Arthritis in Wistar Rat Model [0.03%]
虾青素-水凝胶的环氧合酶-2抑制和抗血小板聚集活性与洛索洛芬的对比研究及其对大鼠类风湿性关节炎的作用
Anzeela Ghaffar,Sumaira Sharif,Quindeel Naveed et al.
Anzeela Ghaffar et al.
Rheumatoid arthritis is an auto-immune disease, commonly treated with celecoxib (Cyclooxygenase-2 inhibitor), which comes with serious cardiovascular threats. Astaxanthin is a natural carotenoid, possessing extraordinary anti-inflammatory a...
Yu-Ting Liu,Xue-Yan Gou,Lu Gan et al.
Yu-Ting Liu et al.
Ampicillin (AMP) is an organic anion drug widely used in clinical setting as a β-lactam antibiotic. However, the specific transporter involved in mediating AMP transport remains unidentified. Thus, we investigated whether organic anion tra...
Vector-Based Comparison and Average Slope Can Refine Bioequivalence Claims: A Machine and Deep Learning Approach [0.03%]
基于向量的比较和平均斜率能精炼生物等效性的主张：一种机器和深度学习方法
Maria Kokkali,Vangelis D Karalis
Maria Kokkali
This study explored the advantages of two innovative concepts: AS and VBC. AS is a pharmacokinetic parameter that measures absorption rates, whereas VBC analyzes clinical endpoints as vectors, breaking them into independent components. Toge...
Pharmacokinetic Studies of a Novel c-Met Targeting PROTAC Drug Candidate Using UPLC-MS/MS Quantification Methods [0.03%]
一种新型c-Met靶向PROTAC药物候选物的药代动力学研究及其UPLC-MS/MS定量方法
Yan Gao,Xinyu Li,Chao Xin et al.
Yan Gao et al.
TPD354 is a novel Proteolysis Targeting Chimera (PROTAC) drug candidate that targets the degradation of cellular mesenchymal-epithelial transforming factor (c-Met) kinase. It showed significant therapeutic efficacy in vivo gastric cancer mo...
Nose to Brain Delivery of Curcumin Loaded Therapeutic Nanostructures for Neurodegenerative Diseases [0.03%]
载姜黄素纳米治疗结构的鼻脑递送用于神经退行性疾病
Rupsikha Kalita,Anupam Sarma,Himakshi Baruah et al.
Rupsikha Kalita et al.
Neurodegenerative diseases are progressive disorders that damage and eventually kill neurons in the central nervous system (CNS). In recent years, various research has been done on reliable and effective treatment methods for the most commo...
Comparative Study on Cannabidiol-Loaded Solubilizing Systems for Improvement of Oral Bioavailability: Liposome and Cyclodextrin-Based Formulations [0.03%]
用于改善大麻二酚口服生物利用度的增溶体系（脂质体与环糊精）比较研究
Hideyuki Sato,Kenta Watanabe,Ryuji Yagi et al.
Hideyuki Sato et al.
This study aimed to develop a CBD-loaded liposomal formulation (LIP/CBD) to improve its physicochemical properties and oral bioavailability (BA). LIP/CBD was prepared by the conventional solvent injection method. The physicochemical and pha...
Development of a Physiologically Based Pharmacokinetic (PBPK) Simulation Model for Nicotine [0.03%]
尼古丁生理药动学（PBPK）模拟模型的开发
Brian Kim,Sung Hun Bae,Mohamed Bashar et al.
Brian Kim et al.
Tobacco is a major cause of chronic diseases such as lung cancer, cardiovascular disease, and chronic obstructive pulmonary disease worldwide. Nicotine, the primary psychoactive component in tobacco, is highly addictive and while not the pr...
Across-Species Meta-Analysis of Betamethasone Pharmacokinetics Utilizing a Minimal PBPK Model [0.03%]
利用精简的生理基于空间模型进行跨物种贝他米松药代动力学 meta 分析研究
Congyu Zhang,William J Jusko
Congyu Zhang
The pharmacokinetic (PK) profiles and parameters of betamethasone (BET) in seven species were collected and reviewed from the literature along with in-house rat data. The apparent clearance (CL/F) of BET was first evaluated using traditiona...
Integration of Data-Driven Techniques in Nanomedicines to Address Diagnosis and Drug Delivery Strategy for Therapy [0.03%]
数据驱动技术在纳米医药中的融合以解决诊断和治疗的药物输送策略问题
Koyeli Girigoswami,Agnishwar Girigoswami
Koyeli Girigoswami
The progress of drug designing, drug delivery systems (DDS), and disease diagnostic systems has significantly advanced pharmaceutical development, as evidenced by the FDA-approved nanomedicines with enhanced selectivity, controlled release,...
Enhanced Vatiquinone Bioavailability With Fatty Meals and Optimal Dosing Schedule [0.03%]
脂肪餐与最佳给药时间可增强瓦他醌生物利用度
Lucy Lee,Katsuyuki Murase,Martin Thoolen et al.
Lucy Lee et al.
Vatiquinone, a 15-lipoxygenase (LO) inhibitor, is an orally bioavailable small molecule being developed for the treatment of Friedreich's ataxia, a disorder characterized by high levels of oxidative stress and dysregulation of energy metabo...