Across-Species Meta-Analysis of Betamethasone Pharmacokinetics Utilizing a Minimal PBPK Model [0.03%]
利用精简的生理基于空间模型进行跨物种贝他米松药代动力学 meta 分析研究
Congyu Zhang,William J Jusko
Congyu Zhang
The pharmacokinetic (PK) profiles and parameters of betamethasone (BET) in seven species were collected and reviewed from the literature along with in-house rat data. The apparent clearance (CL/F) of BET was first evaluated using traditiona...
Integration of Data-Driven Techniques in Nanomedicines to Address Diagnosis and Drug Delivery Strategy for Therapy [0.03%]
数据驱动技术在纳米医药中的融合以解决诊断和治疗的药物输送策略问题
Koyeli Girigoswami,Agnishwar Girigoswami
Koyeli Girigoswami
The progress of drug designing, drug delivery systems (DDS), and disease diagnostic systems has significantly advanced pharmaceutical development, as evidenced by the FDA-approved nanomedicines with enhanced selectivity, controlled release,...
Enhanced Vatiquinone Bioavailability With Fatty Meals and Optimal Dosing Schedule [0.03%]
脂肪餐与最佳给药时间可增强瓦他醌生物利用度
Lucy Lee,Katsuyuki Murase,Martin Thoolen et al.
Lucy Lee et al.
Vatiquinone, a 15-lipoxygenase (LO) inhibitor, is an orally bioavailable small molecule being developed for the treatment of Friedreich's ataxia, a disorder characterized by high levels of oxidative stress and dysregulation of energy metabo...
Contribution of Organic Anion Transporter 3 in Delayed Elimination of Methotrexate by Concomitant Administration of Febuxostat [0.03%]
Febuxostat通过有机阴离子转运蛋白3延迟甲氨蝶呤的消除的作用及机制研究
Kenji Ikemura,Sakura Kobayashi,Danni Wang et al.
Kenji Ikemura et al.
Methotrexate is an antifolate agent used for the treatment of various malignancies and is mainly secreted via human organic anion transporter 3 (hOAT3) in the proximal tubular cells. Coadministration of the xanthine oxidase inhibitor, febux...
The Role of Nasal Drug Delivery in Migraine Management and Brain-Targeted Therapy: Insights From Taiwan [0.03%]
台湾鼻用药物递送在偏头痛管理及脑靶向治疗中的作用：见解与展望
Lien-Chung Wei,Hsien-Jane Chiu
Lien-Chung Wei
This letter responds to a recent review on nasal drug delivery systems for brain-targeted therapy. Drawing on first hand experiences as a psychiatrist and migraine patient in Taiwan, the response discusses the practical benefits and challen...
The Effect of α-Mangostin on the Pharmacokinetic Profile of Tofacitinib in Rats Both In Vitro and In Vivo [0.03%]
α- mangostin 体内外对托法替布药动学特征的影响研究
Jiange Yao,Zebei Lu,Quan Zhou et al.
Jiange Yao et al.
This study investigated the effects of α-mangostin (α-MG) on the pharmacokinetics of tofacitinib in vitro and in vivo, aiming to recommend its appropriate application in clinical practice. To investigate the values of IC50 and inhibition ...
Pharmacokinetic Study of Cefditoren Pivoxil in Breast Milk and Blood of Lactating Women [0.03%]
乳腺feeding妇女的塞诺匹肟酯组织分布研究（乳汁和血液中的药动学）
Zhuo Chen,Shiyin Feng,Linrui Cai et al.
Zhuo Chen et al.
To provide a theoretical basis for the rational use of cefditoren pivoxil in lactating women by conducting a pharmacokinetic study of cefditoren in the blood and milk of these women. Twelve participants meeting the inclusion criteria took c...
Multifaceted Evaluation of Nano Encapsulated Polymeric Scopoletin Against HT-29 Colon Cancer Cells [0.03%]
纳米封装聚集体Scopoletin对HT-29结肠癌细胞的多方位评价
Kunnathur Murugesan Sakthivel,Rajan Radha Rasmi,Kalavathy Murugan Kumar et al.
Kunnathur Murugesan Sakthivel et al.
In the sphere of medical research, nanoencapsulated polymeric drugs in biological circumstances are an intriguing issue for therapeutical diagnosis. The nanoprecipitation approach was employed in this study to synthesis the nanoencapsulated...
Effect of Curcuminoids on Pharmacokinetics and Pharmacodynamics of Atorvastatin in Hyperlipidemia Rats and Its Potential Mechanism [0.03%]
姜黄素类化合物对高脂血症大鼠阿托伐他汀药动学和药效学的影响及其可能机制研究
Jiao Li,Jinzhen Wang,Benlu Zhong et al.
Jiao Li et al.
Curcuminoids (CURs), natural polyphenols, are often combined with atorvastatin to treat hyperlipidemia. In order to assess the safety of combination, the effect of CURs on Cytochrome P450 (CYP) 3A2 activity in rats was investigated. Additio...
Inhibition Mechanism of Ketamine-Apatinib by CYP2C9 and 3A4: A Prediction of Possible Drug-Drug Interaction [0.03%]
氯胺酮-阿帕替尼抑制CYP2C9和3A4的机制及其潜在药物相互作用预测
Xiang Zheng,Haiyan Chen,Dan Lin et al.
Xiang Zheng et al.
Most cancer patients experience severe pain, and apatinib, a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, demonstrates therapeutic efficacy against gastric cancer. Ketamine, a psychotropic drug used for cancer pain reli...