Prediction of Human Serum Concentration-Time Profiles of Golimumab and Ustekinumab Using Pharmacokinetic Data From Common Marmosets With Assessment of Anti-Drug Antibodies [0.03%]
利用常见狨猴的药代动力学数据预测戈利木单抗和尤特克珠单抗的人类血清浓度-时间曲线，并评估药物抗体反应
Ayaka Tajiri,Shogo Matsumoto,Nanami Furukawa et al.
Ayaka Tajiri et al.
In a previous study, retrospective predictions of human serum concentration-time profiles for three therapeutic monoclonal antibodies (mAbs) with linear pharmacokinetics were performed using allometric scaling in common marmosets and achiev...
Optimized GFR Estimation Equations for Chinese Neonates and Children: Development of New Models and Comparison With Existing Ones [0.03%]
中国新生儿和儿童优化的肾小球滤过率估算方程：新模型的发展与现有模型比较
Hiotong Lam,Yahui Zhang,Zhe Hou et al.
Hiotong Lam et al.
Glomerular filtration rate (GFR) maturation is critical for drug dosing in neonates and children. Current equations face dual limitations: they are primarily derived from Caucasian populations and fail to account for the fundamental physiol...
Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb-Drug Interaction Investigation [0.03%]
板蓝根补充对艾替拉韦及法匹拉韦药代动力学影响的评估：一项药物与草药相互作用的研究
Siva Nageswara Rao Gajula,Jeevan Sai Kallam,Aarika Kanukolanu et al.
Siva Nageswara Rao Gajula et al.
Echinacea is a widely used herbal supplement and is frequently co-administered with antiviral drugs, raising concerns regarding potential herb-drug interactions. This study evaluated the effect of repeated Echinacea administration on the ph...
A Slowly Self-Emulsifying Delivery System of Sesamin With Improved Biopharmaceutical Properties [0.03%]
一种改善了药代动力学特性的葫芦巴素缓慢自我乳化输运系统
Duyen Thi My Ho,Kohei Yamada,Hideyuki Sato et al.
Duyen Thi My Ho et al.
This study is the first attempt to develop a novel slowly self-emulsifying drug delivery system (SL-SEDDS) of sesamin (SES) for improved biopharmaceutical properties. Firstly, SES-loaded self-emulsifying drug delivery system (SEDDS/SES) com...
Ointment for Topical Ocular Delivery of Voriconazole: Formulation Development, In-Vitro Characterization & In-Vivo Pharmacokinetic Assessment [0.03%]
伏立康唑眼用软膏的制剂开发、体外表征及体内药代动力学评估
Amol Chhatrapati Bisen,Ayush Dubey,Sachin Nashik Sanap et al.
Amol Chhatrapati Bisen et al.
Voriconazole (VCZ) is a broad-spectrum antifungal agent widely used for treating fungal infections caused by Candida, Aspergillus, and Fusarium species, which are commonly associated with fungal keratitis (FK). Topical ophthalmic ointments ...
Corneal Targeted Mucoadhesive Emulsion for Prolonged Delivery of Voriconazole: Formulation Evaluation and Pharmacokinetic Assessment [0.03%]
制备长效递送伏立康唑的角膜靶向粘附凝胶乳剂及其评价
Amol Chhatrapati Bisen,Saurabh Srivastava,Sachin Nashik Sanap et al.
Amol Chhatrapati Bisen et al.
Voriconazole, a broad-spectrum triazole antifungal, is widely prescribed for fungal keratitis (FK) caused by Candida, Aspergillus, and Fusarium species. Conventional ophthalmic solutions are limited by rapid clearance and low bioavailabilit...
A Novel Slowly Self-Emulsifying Drug Delivery System: Prolonged Systemic Exposure of Tacrolimus With Reduced Risks of Systemic Side Effects [0.03%]
一种新型的缓慢自我乳化药物递送系统：通过减少全身副作用的风险延长他克莫司的全身暴露量
Kohei Yamada,Keiya Sonobe,Akihisa Miura et al.
Kohei Yamada et al.
This study aimed to design and characterize a new type of self-emulsifying drug delivery system (SEDDS), slowly SEDDS (SL-SEDDS), for long-lasting systemic exposure of tacrolimus (TAC) with reduced nephrotoxicity. TAC-loaded SL-SEDDS (SL-SE...
Improvement of XZP8257 Dissolution Properties Through Amorphous and Mixed-Phase Precipitate Formation in Biorelevant Media [0.03%]
通过生物相关介质中无定形和混合相沉淀的形成改善XZP8257的溶出性质
Miao Zhang,Shudong Zhang,Bin Wu et al.
Miao Zhang et al.
Although precipitation of poorly soluble drugs in the gastrointestinal (GI) tract is often considered detrimental to bioavailability, the solid-state nature of the precipitate, either crystalline or amorphous, may critically redefine its im...
Cyclooxygenase-2 Inhibition and Anti-Platelet Aggregation Activity of Astaxanthin-Hydrogel in Comparison to Celecoxib Against Rheumatoid Arthritis in Wistar Rat Model [0.03%]
虾青素-水凝胶的环氧合酶-2抑制和抗血小板聚集活性与洛索洛芬的对比研究及其对大鼠类风湿性关节炎的作用
Anzeela Ghaffar,Sumaira Sharif,Quindeel Naveed et al.
Anzeela Ghaffar et al.
Rheumatoid arthritis is an auto-immune disease, commonly treated with celecoxib (Cyclooxygenase-2 inhibitor), which comes with serious cardiovascular threats. Astaxanthin is a natural carotenoid, possessing extraordinary anti-inflammatory a...
Yu-Ting Liu,Xue-Yan Gou,Lu Gan et al.
Yu-Ting Liu et al.
Ampicillin (AMP) is an organic anion drug widely used in clinical setting as a β-lactam antibiotic. However, the specific transporter involved in mediating AMP transport remains unidentified. Thus, we investigated whether organic anion tra...