Indiscriminate activities of different henipavirus polymerase complex proteins allow for efficient minigenome replication in hybrid systems [0.03%]
不分化的henipavirus聚合酶复合蛋白的活性使其能够在杂合系统中有效复制最小基因组
Xiao Li,Yanling Yang,Carolina B López
Xiao Li
The henipaviruses, including Nipah virus (NiV) and Hendra virus (HeV), are biosafety level 4 (BSL-4) zoonotic pathogens that cause severe neurological and respiratory disease in humans. To study the replication machinery of these viruses, w...
Tripartite motif-containing protein 21 is involved in IFN-γ-induced suppression of hepatitis B virus by regulating hepatocyte nuclear factors [0.03%]
三聚体基序含有的蛋白质21通过调节肝细胞核因子参与干扰素γ诱导的乙肝病毒抑制作用
Juhee Won,Hong Seok Kang,Na Yeon Kim et al.
Juhee Won et al.
The antiviral role of the tripartite motif-containing (TRIM) protein family , a member of the E3-ubiquitin ligase family, has recently been actively studied. Hepatitis B virus (HBV) infection is a major contributor to liver diseases; howeve...
P3N-PIPO but not P3 is the avirulence determinant in melon carrying the Wmr resistance against watermelon mosaic virus, although they contain a common genetic determinant [0.03%]
含有Wmr抗病基因的甜瓜中，P3N-PIPO而不是P3是西瓜花叶病毒的致病性决定因子，尽管他们含有一个共同的遗传决定因子
Zhen Sun,Yu-Xuan Wu,Ling-Zhi Liu et al.
Zhen Sun et al.
Viruses employ a series of diverse translational strategies to expand their coding capacity, which produces viral proteins with common domains and entangles virus-host interactions. P3N-PIPO, which is a transcriptional slippage product from...
Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection [0.03%]
阻断TIGIT的免疫重建不足以控制慢性的猴免疫缺陷病毒感染
Gabriela M Webb,Cleiton T Pessoa,Allyson J McCullen et al.
Gabriela M Webb et al.
TIGIT is a negative immune checkpoint receptor associated with T cell exhaustion in cancer and HIV. TIGIT upregulation in virus-specific CD8+ T cells and NK cells during HIV/SIV infection results in dysfunctional effector capabilities. In v...
GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB [0.03%]
GRP78与CHUK/IKBKB相互作用识别EV-F 3D蛋白并激活NF-κB抑制病毒复制
Xiaoran Chang,Yidi Guo,Qun Zhang et al.
Xiaoran Chang et al.
Enteroviruses are the causative agents associated with several human and animal diseases, posing a significant threat to human and animal health. As one of the host immune defense strategies, innate immunity plays a crucial role in defendin...
Role of the membrane-associated accessory protein (MAAP) in adeno-associated virus (AAV) infection [0.03%]
膜相关辅助蛋白(MAAP)在腺相关病毒(AAV)感染中的作用
Cagla Aksu Kuz,Kang Ning,Siyuan Hao et al.
Cagla Aksu Kuz et al.
Adeno-associated viruses (AAVs) package a single-stranded (ss) DNA genome of 4.7 kb in their capsid of ~20 nm in diameter. AAV replication requires co-infection of a helper virus, such as adenovirus. During the optimization of recombinant A...
AcMNPV P74 is cleaved at R325 and R334 by proteinases of both OB and BBMV to expose a potential fusion peptide for oral infection [0.03%]
AcMNPV P74 在 OB 和 BBMV 蛋白酶的作用下在 R325 和 R334 位被切割以暴露其潜在的融合肽用于口服感染
Zhuorui Li,Nan Zhang,Tao Zhang et al.
Zhuorui Li et al.
Baculoviruses enter insect midgut epithelial cells via a set of occlusion-derived virion (ODV) envelope proteins called per os infectivity factors (PIFs). P74 of Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV), which was th...
A cell cycle regulator, E2F2, and glucocorticoid receptor cooperatively transactivate the bovine alphaherpesvirus 1 immediate early transcription unit 1 promoter [0.03%]
牛α疱疹病毒1型即时早期转录单位1启动子的转录受细胞周期调节因子E2F2和糖皮质激素受体协同激活的影响
Fouad S El-Mayet,Clinton Jones
Fouad S El-Mayet
Bovine alphaherpesvirus 1 (BoHV-1) infection causes respiratory tract disorders and immune suppression and may induce bacterial pneumonia. BoHV-1 establishes lifelong latency in sensory neurons after acute infection. Reactivation from laten...
Bacteriophage cocktail shows no toxicity and improves the survival of Galleria mellonella infected with Klebsiella spp [0.03%]
噬菌体鸡尾酒疗法对感染肺炎克雷伯菌的大蜡螟无毒性并可提高其存活率
Lucy Kelly,Eleanor Jameson
Lucy Kelly
Klebsiella spp. are causative agents of healthcare-associated infections in patients who are immunocompromised and use medical devices. The antibiotic resistance crisis has led to an increase in infections caused by these bacteria, which ca...
Sequence polymorphisms in the reovirus σ1 attachment protein modulate encapsidation efficiency and replication in mice [0.03%]
轮状病毒σ1附着蛋白的序列多态性调节其包装效率及小鼠体内的复制能力
Olivia L Welsh,Alexa N Roth,Danica M Sutherland et al.
Olivia L Welsh et al.
Many functions of viral attachment proteins are established, but less is known about the biological importance of viral attachment protein encapsidation efficiency. The mammalian orthoreovirus (reovirus) σ1 attachment protein forms filamen...