An efficient trans complementation system for in vivo replication of defective poliovirus mutants [0.03%]
一个在活体内复制缺陷型脊髓灰质炎病毒突变体的有效转换互补系统
Minetaro Arita
Minetaro Arita
The picornavirus genome encodes a large, single polyprotein that is processed by viral proteases to form an active replication complex. The replication complex is formed with the viral genome, host proteins, and viral proteins that are prod...
Human cytomegalovirus glycoprotein variants governing viral tropism and syncytium formation in epithelial cells and macrophages [0.03%]
人巨细胞病毒糖蛋白变异体决定病毒趋向性及上皮细胞和巨噬细胞中合胞体的形成
Giorgia Cimato,Xuan Zhou,Wolfram Brune et al.
Giorgia Cimato et al.
Human cytomegalovirus (HCMV) displays a broad cell tropism, and the infection of biologically relevant cells such as epithelial, endothelial, and hematopoietic cells supports viral transmission, systemic spread, and pathogenesis in the huma...
Macaque antibodies targeting Marburg virus glycoprotein induced by multivalent immunization [0.03%]
多价免疫诱导的针对马堡病毒糖蛋白的猕猴抗体
Benjamin M Janus,Ruixue Wang,Thomas E Cleveland th et al.
Benjamin M Janus et al.
Marburg virus infection in humans is associated with case fatality rates that can reach up to 90%, but to date, there are no approved vaccines or monoclonal antibody (mAb) countermeasures. Here, we immunized Rhesus macaques with multivalent...
A broadly neutralizing human monoclonal antibody generated from transgenic mice immunized with HCMV particles limits virus infection and proliferation [0.03%]
由接种人巨细胞病毒颗粒免疫的小鼠产生的广谱中和单克隆抗体限制病毒的感染及增殖
Kristina E Atanasoff,Andrea J Parsons,Sabrina I Ophir et al.
Kristina E Atanasoff et al.
Human cytomegalovirus (HCMV) is a β-herpesvirus that poses severe disease risk for immunocompromised patients who experience primary infection or reactivation. Development and optimization of safe and effective anti-HCMV therapeutics is of...
Acinetobacter baumannii satellite phage Aci01-2-Phanie depends on a helper myophage for its multiplication [0.03%]
鲍曼不动杆菌卫星噬菌体Aci01-2-Phanie的增殖依赖于一个辅助作用的溶源噬菌体
Christine Pourcel,Christiane Essoh,Malika Ouldali et al.
Christine Pourcel et al.
We report the discovery of a satellite-helper phage system with a novel type of dependence on a tail donor. The Acinetobacter baumannii satellite podovirus Aci01-2-Phanie (short name Phanie) uses a phage phi29-like DNA replication and packa...
Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques [0.03%]
弗林蛋白酶活化剂可增强基于 Arenavirus 病毒载体的猴免疫缺陷病毒疫苗在恒河猴中的抗原性
Archana Vidya Boopathy,Anurag Nekkalapudi,Janette Sung et al.
Archana Vidya Boopathy et al.
Arenaviral vaccine vectors encoding simian immunodeficiency virus (SIV) immunogens are capable of inducing efficacious humoral and cellular immune responses in nonhuman primates. Several studies have evaluated the use of immune modulators t...
A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses [0.03%]
全长糖蛋白mRNA疫苗可完全保护塞卡病毒属病毒，具有广谱抗班达病毒的效果
Jia Lu,Jun Liu,Yan Wu et al.
Jia Lu et al.
Highly pathogenic viruses from family Phenuiviridae, which are mainly transmitted by arthropods, have intermittently sparked epidemics worldwide. In particular, tick-borne bandaviruses, such as severe fever with thrombocytopenia syndrome vi...
Porcine deltacoronavirus nucleocapsid protein antagonizes JAK-STAT signaling pathway by targeting STAT1 through KPNA2 degradation [0.03%]
猪 deltacornavirus 核衣壳蛋白通过降解 KPNA2 招募并灭活 STAT1 干扰JAK-STAT信号通路
Yating Hu,Chenlin Hao,Donghan Wang et al.
Yating Hu et al.
Porcine deltacoronavirus (PDCoV) is an enteric pathogenic coronavirus that causes acute and severe watery diarrhea in piglets and has the ability of cross-species transmission, posing a great threat to swine production and public health. Th...
Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion [0.03%]
二肽基肽酶4与猪冠状病毒PHEV刺突蛋白相互作用并介导宿主范围的扩大
Junchao Shi,Shiyu Hu,Hanlu Wei et al.
Junchao Shi et al.
Porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic betacoronavirus, is prevalent in natural reservoir pigs and infects mice. This raises concerns about host jumping or spillover, but little is known about the cause of oc...
Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL31.6 of herpes simplex virus 1 [0.03%]
鉴定出一种新的神经毒力因子 它由单纯疱疹病毒1型的隐秘孤儿基因UL31.6编码
Akihisa Kato,Ryoji Iwasaki,Kousuke Takeshima et al.
Akihisa Kato et al.
Although the herpes simplex virus type 1 (HSV-1) genome was thought to contain approximately 80 different protein coding sequences (CDSs), recent multi-omics analyses reported HSV-1 encodes more than 200 potential CDSs. However, few of the ...