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Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion

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Porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic betacoronavirus, is prevalent in natural reservoir pigs and infects mice. This raises concerns about host jumping or spillover, but little is known about the cause of occurrence. Here, we r... ...