The F-box E3 ligase protein FBXO11 regulates EBNA3C-associated degradation of BCL6 [0.03%]
F盒E3连接酶蛋白FBXO11调控EBNA3C泛素化降解BCL6
Kunfeng Sun,Dipayan Bose,Rajnish Kumar Singh et al.
Kunfeng Sun et al.
Most mature B-cell malignancies originate from the malignant transformation of germinal center (GC) B cells. The GC reaction appears to have a role in malignant transformation, in which a major player of the GC reaction is BCL6, a key regul...
In vivo efficacy of phage cocktails against carbapenem resistance Acinetobacter baumannii in the rat pneumonia model [0.03%]
噬菌体鸡尾酒制剂对肺炎模型中碳青霉烯耐药的鲍曼不动杆菌的体内疗效研究
Shibin Li,Bingdong Wei,Le Xu et al.
Shibin Li et al.
Acinetobacter baumannii, an opportunistic pathogen, poses a significant threat in intensive care units, leading to severe nosocomial infections. The rise of multi-drug-resistant strains, particularly carbapenem-resistant A. baumannii, has c...
Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas [0.03%]
多聚酶theta是靶向杀伤Epstein-Barr病毒淋巴瘤的合成致死靶点
Griffin H Willman,Huanzhou Xu,Travis M Zeigler et al.
Griffin H Willman et al.
Treatment options for Epstein-Barr virus (EBV)-cancers are limited, underscoring the need for new therapeutic approaches. We have previously shown that EBV-transformed cells and cancers lack homologous recombination (HR) repair, a prominent...
Antagonism of epidermal growth factor receptor signaling favors hepatitis E virus life cycle [0.03%]
表皮生长因子信号通路的拮抗有利于戊型肝炎病毒的生命活动周期
Kathrin Woytinek,Mirco Glitscher,Eberhard Hildt
Kathrin Woytinek
Hepatitis E virus (HEV) poses a global threat, which currently remains understudied in terms of host interactions. Epidermal growth factor receptor (EGFR) plays multifaceted roles in viral pathogenesis, impacting host-cell entry, viral repl...
Ambiviricota, a novel ribovirian phylum for viruses with viroid-like properties [0.03%]
具类病毒特性的病毒成立新核糖病毒门“Ambiviricota”
Jens H Kuhn,Leticia Botella,Marcos de la Peña et al.
Jens H Kuhn et al.
Fungi harbor a vast diversity of mobile genetic elements (MGEs). Recently, novel fungal MGEs, tentatively referred to as 'ambiviruses,' were described. 'Ambiviruses' have single-stranded RNA genomes of about 4-5 kb in length that contain at...
Changes in the chikungunya virus E1 glycoprotein domain II and hinge influence E2 conformation, infectivity, and virus-receptor interactions [0.03%]
鸡波尼亚病毒E1糖蛋白结构域II和铰链区的变化影响E2构象、感染性和病毒受体相互作用
Sara A Thannickal,Leandro Battini,Sophie N Spector et al.
Sara A Thannickal et al.
In a previous study to understand how the chikungunya virus (CHIKV) E1 glycoprotein β-strand c functions, we identified several attenuating variants at E1 residue V80 and the emergence of second-site mutations in the fusion loop (E1-M88L) ...
Siah2- and LRSAM1-mediated K63-linked ubiquitination of snakehead vesiculovirus nucleoprotein facilitates viral replication [0.03%]
沙保病毒核蛋白的K63连接多泛素化促进病毒感染：SIAH2和LRSAM1介导的调控作用
Ningyan Jiang,Hongyan Zhao,Xiangmou Qin et al.
Ningyan Jiang et al.
Nucleoprotein (N) is well known for its function in the encapsidation of the genomic RNAs of negative-strand RNA viruses, which leads to the formation of ribonucleoproteins that serve as templates for viral transcription and replication. Ho...
Interferon-γ inducible factor 16 (IFI16) restricts adeno-associated virus type 2 (AAV2) transduction in an immune-modulatory independent way [0.03%]
干扰素诱导因子16（IFI16）以免疫调节独立的方式限制腺相关病毒2型（AAV2）的转导作用
Sereina O Sutter,Kurt Tobler,Michael Seyffert et al.
Sereina O Sutter et al.
We determined the transcription profile of adeno-associated virus type 2 (AAV2)-infected primary human fibroblasts. Subsequent analysis revealed that cells respond to AAV infection through changes in several significantly affected pathways,...
Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI [0.03%]
人腺病毒小衣壳蛋白VI对线粒体信号的复杂调控作用
Erik Schubert,Kwangchol Mun,Mårten Larsson et al.
Erik Schubert et al.
The controlled release of mitochondrial content into the cytosol has emerged as one of the key steps in mitochondrial signaling. In particular, the release of mitochondrial DNA (mtDNA) into the cytosol has been shown to activate interferon ...
Generation of single-round infectious rotavirus with a mutation in the intermediate capsid protein VP6 [0.03%]
通过中间衣壳蛋白VP6的突变产生单轮感染性轮状病毒
Tomohiro Kotaki,Yuta Kanai,Megumi Onishi et al.
Tomohiro Kotaki et al.
Rotavirus causes severe diarrhea in infants. Although live attenuated rotavirus vaccines are available, vaccine-derived infections have been reported, which warrants development of next-generation rotavirus vaccines. A single-round infectio...