Subnanometer structure of medusavirus capsid during maturation using cryo-electron microscopy [0.03%]
利用冷冻电子显微镜解析玻璃蛙病毒成熟过程中的衣壳亚纳米结构
Ryoto Watanabe,Chihong Song,Masaharu Takemura et al.
Ryoto Watanabe et al.
Medusavirus is a giant virus classified into an independent family of Mamonoviridae. Amoebae infected with medusavirus release immature particles in addition to virions. These particles were suggested to exhibit the maturation process of th...
Characterization of viroplasm-like structures by co-expression of NSP5 and NSP2 across rotavirus species A to J [0.03%]
NSP5和NSP2跨表达诱导不同轮状病毒种群形成类似复制体结构
Melissa Lee,Ariana Cosic,Kurt Tobler et al.
Melissa Lee et al.
Rotaviruses (RVs) are classified into nine species, A-D and F-J, with species A being the most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are cytosolic globular inclusions composed of main building blo...
LKB1 suppresses KSHV reactivation and promotes primary effusion lymphoma progression [0.03%]
LKB1抑制KSHV再活化并促进原发性渗出性淋巴瘤的发展
Guanya Li,Yinan Li,Xinyu Tang et al.
Guanya Li et al.
Viruses normally reprogram the host cell metabolic pathways as well as metabolic sensors to facilitate their persistence. The serine-threonine liver kinase B1 (LKB1) is a master upstream kinase of 5'-AMP-activated protein kinase (AMPK) that...
Nectin1 is a pivotal host factor involved in attachment and entry of red-spotted grouper nervous necrosis virus in the early stages of the viral life cycle [0.03%]
nectin1是红点斑姑鱼神经坏死病毒生活周期早期吸附和入侵的关键宿主因子
Zhiqi Zhang,Jing Xing,Xiaoqian Tang et al.
Zhiqi Zhang et al.
Nervous necrosis virus (NNV) is a highly neurotropic virus that poses a persistent threat to the survival of multiple fish species. However, its inimitable neuropathogenesis remains largely elusive. To rummage potential partners germane to ...
Requirement of the N-terminal region of nonstructural protein 1 in cis for SARS-CoV-2 defective RNA replication [0.03%]
SARS-CoV-2缺陷性复制子RNA的内源性N端非结构蛋白1需求
Kaori Terasaki,Shinji Makino
Kaori Terasaki
SARS-CoV-2 belongs to the family Coronaviridae and carries a single-stranded positive-sense RNA genome. During coronavirus (CoV) replication, defective or defective interfering RNAs that lack a large portion of the genome often emerge. Thes...
The cellular protein phosphatase 2A is a crucial host factor for Marburg virus transcription [0.03%]
细胞蛋白磷酸酶2A是马堡病毒转录的关键宿主因子
Isabel von Creytz,Cornelius Rohde,Nadine Biedenkopf
Isabel von Creytz
Little is known regarding the molecular mechanisms that highly pathogenic Marburg virus (MARV) utilizes to transcribe and replicate its genome. Previous studies assumed that dephosphorylation of the filoviral transcription factor VP30 suppo...
Protective role of cytosolic prion protein against virus infection in prion-infected cells [0.03%]
细胞内_prPC_通过干扰病毒脱壳抑制病原感染
Hideyuki Hara,Junji Chida,Batzaya Batchuluun et al.
Hideyuki Hara et al.
Production of the amyloidogenic prion protein, PrPSc, which forms infectious protein aggregates, or prions, is a key pathogenic event in prion diseases. Functional prion-like protein aggregations, such as the mitochondrial adaptor protein M...
Breast milk induces the differentiation of monocytes into macrophages, promoting human cytomegalovirus infection [0.03%]
母乳可诱导单核细胞分化成为巨噬细胞并促进人巨细胞病毒感染
Xiaodan Cai,Nicole T Padilla,Kristina Rosbe et al.
Xiaodan Cai et al.
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus found in human breast milk that is frequently transmitted from HCMV-seropositive mothers to their infants during the postnatal period. Despite extensive research, the mechanisms under...
Host WD repeat-containing protein 5 inhibits protein kinase R-mediated integrated stress response during measles virus infection [0.03%]
WD重复蛋白5通过抑制麻疹病毒感染中的蛋白质激酶R介导的综合应激反应发挥宿主作用
Ethan BenDavid,Chuyuan Yang,Yuqin Zhou et al.
Ethan BenDavid et al.
Some negative-sense RNA viruses, including measles virus (MeV), share the characteristic that during their infection cycle, cytoplasmic inclusion bodies (IBs) are formed where components of the viral replication machinery are concentrated. ...
miR-451-targeted PSMB8 promotes PRRSV infection by degrading IRF3 [0.03%]
miR-451靶向PSMB8通过降解IRF3促进PRRSV感染
Sihan Li,Shuyuan Guo,Fang Liu et al.
Sihan Li et al.
Porcine respiratory and reproductive syndrome (PRRS) is one of the most devastating infectious diseases of pigs, causing reproductive failures in sows and severe respiratory symptoms in piglets and growing pigs. MicroRNAs (miRNAs) are repor...