Molnupiravir inhibits Bourbon virus infection and disease-associated pathology in mice [0.03%]
Molnupiravir抑制 Bourbon病毒对小鼠的感染和疾病相关病理症状
Gayan Bamunuarachchi,Fang R Zhao,Traci L Bricker et al.
Gayan Bamunuarachchi et al.
Bourbon virus (BRBV) is an emerging tick-borne virus that can cause severe and fatal disease in humans. BRBV is vectored via the Amblyomma americanum tick, which is widely distributed throughout the central, eastern, and southern United Sta...
Residues 27T and 297A in VP2 contribute to the enhanced replication and pathogenicity of raccoon dog parvovirus [0.03%]
VP2中的残基27T和297A有助于银黑狐细小病毒增殖性和致病性的增强
Liwen Xu,Wenyu Cao,Yawen Liu et al.
Liwen Xu et al.
Raccoon dog parvovirus (RDPV) is a highly contagious pathogen causing severe hemorrhagic enteritis that is fatal in young raccoon dogs. Since 2016, epidemiological investigations have documented recurrent outbreaks of RDPV, exhibiting heigh...
Intra-host SARS-CoV-2 diversity in immunocompromised people living with HIV provides insight into the evolutionary trajectory of SARS-CoV-2 [0.03%]
HIV感染者的新冠病毒多样性揭示了免疫缺陷宿主中sarscov-2的进化方向
R Joseph,G Marais,I Iranzadeh et al.
R Joseph et al.
Ongoing viral evolution in immunocompromised individuals with persistent infection may facilitate the evolution of SARS-CoV-2 and emergence of variants of concern (VOC). This study was conducted in the Western Cape Province of South Africa ...
An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon [0.03%]
SARS-CoV-2刺突蛋白上的一个RGD基序可诱导TGF-β信号并下调I型干扰素反应
Nicholas P Gracie,Anupriya Aggarwal,Rachel Luo et al.
Nicholas P Gracie et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates canonical cell entry via ACE2 and has also been implicated as an activator of a diverse range of signaling pathways. Here, we present evidence that ...
Correction for Oom et al., "The two-dose MVA-BN mpox vaccine induces a nondurable and low avidity MPXV-specific antibody response" [0.03%]
对Oom等人的文章《两剂MVA-BN猴痘疫苗诱导的非持久且低亲和力MPXV特异性抗体反应》的更正
Aaron L Oom,Kesi K Wilson,Miilani Yonatan et al.
Aaron L Oom et al.
Published Erratum
Journal of virology. 2025 Sep 4:e0087225. DOI:10.1128/jvi.00872-25 2025
An SRR1 domain-containing protein is required for efficient Orsay virus replication in Caenorhabditis elegans [0.03%]
一个含SRR1结构域的蛋白能够使奥萨耶小杆线虫病毒高效复制
Chika Fujii,David Wang
Chika Fujii
Viruses depend on their hosts for completing their life cycle, and a better understanding of virus replication can inform therapeutic strategies. Using the Orsay virus-Caenorhabditis elegans experimental platform, we identified by a forward...
Assessment of hepatitis C virus permissiveness in iteratively genetically humanized mice [0.03%]
迭代基因人类化小鼠中丙型肝炎病毒易感性的评估
Michael P Schwoerer,Sebastian Carver,Thomas R Cafiero et al.
Michael P Schwoerer et al.
Hepatitis C virus (HCV) is an enveloped, positive-sense single-stranded RNA virus causing chronic infections in over 50 million people who are at risk of developing severe liver disease. Greater understanding of HCV pathogenesis and vaccine...
An attenuated African swine fever virus with deletions of the CD2v and A137R genes offers complete protection against homologous challenge in pigs [0.03%]
缺失CD2V和A137R基因的减毒非洲猪瘟病毒对家猪提供完全保护力
Guorui Peng,Xin Zhao,Xingqi Zou et al.
Guorui Peng et al.
African swine fever (ASF) has caused a devastating pandemic among domestic and wild swine, leading to significant economic losses in the global swine industry. Recombinant live-attenuated vaccines are a potential option for the control of A...
Pseudorabies virus induces ferroptosis by disrupting iron homeostasis through activation of TfR1 and ferritinophagy [0.03%]
伪狂犬病毒通过激活TfR1和铁蛋白自噬来破坏铁稳态诱导铁死亡
Zicheng Ma,Lei Guo,Ran Ji et al.
Zicheng Ma et al.
Programmed cell death (PCD) refers to a regulated cellular process involving a cascade of biochemical reactions and molecular mechanisms, commonly including apoptosis, necroptosis, and pyroptosis. Ferroptosis is a recently identified form o...
Yuxin Qu,Jiaqi Li,Hao Deng et al.
Yuxin Qu et al.
Viroporins, virus-encoded small hydrophobic proteins, are involved in critical steps of viral infections by modulating ion homeostasis, disrupting host membrane integrity, and orchestrating key stages of the virus life cycle-from entry and ...