Genetic absence of PD-L1 does not restore CD8+ T cell function during respiratory virus infection and delays virus clearance [0.03%]
PD-L1基因缺失无法在呼吸道病毒感染期间恢复CD8⁺T细胞的功能并延长病毒清除时间
Meredith C Rogers,Kristina D Lamens,Sharon J Tollefson et al.
Meredith C Rogers et al.
A key mediator of T cell impairment during respiratory virus infection is the inhibitory receptor PD-1. PD-1 is induced on T cells following antigen exposure, whereas proinflammatory cytokines upregulate the ligands PD-L1 and PD-L2. Respira...
A model for polyomavirus helicase activity derived in part from the AlphaFold2 structure of SV40 T-antigen [0.03%]
基于痘病毒T抗原的AlphaFold2结构的部分建模多瘤病毒解旋酶活性模型
Jong Shin,Gretchen Meinke,Alex A Bohm et al.
Jong Shin et al.
The mechanism used by polyomavirus and other viral SF3 helicases to unwind DNA at replication forks remains unknown. Using AlphaFold2, we have determined the structure of a representative SF3 helicase, the SV40 T-antigen (T-ag). This model ...
Promotion of order Bunyavirales to class Bunyaviricetes to accommodate a rapidly increasing number of related polyploviricotine viruses [0.03%]
提议将Bunyavirales升为纲Bunyaviricetes以容纳大量相关病毒家族
Jens H Kuhn,Katherine Brown,Scott Adkins et al.
Jens H Kuhn et al.
Prior to 2017, the family Bunyaviridae included five genera of arthropod and rodent viruses with tri-segmented negative-sense RNA genomes related to the Bunyamwera virus. In 2017, the International Committee on Taxonomy of Viruses (ICTV) pr...
Correction for David et al., "Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria" [0.03%]
纠正David等人的文章《共生呼吸细菌的存在增强了流感病毒在飞沫和气溶胶中的稳定性》
Shannon C David,Aline Schaub,Céline Terrettaz et al.
Shannon C David et al.
Published Erratum
Journal of virology. 2024 Oct 22;98(10):e0122224. DOI:10.1128/jvi.01222-24 2024
The loss of hepatitis B virus receptor NTCP/SLC10A1 in human liver cancer cells is due to epigenetic silencing [0.03%]
人肝癌细胞乙肝病毒受体NTCP/SLC10A1的丢失是由于表观遗传学沉默导致的
Marwa K Ibrahim,Cheng-Der Liu,Liyong Zhang et al.
Marwa K Ibrahim et al.
Human Na+-taurocholate cotransporting polypeptide (hNTCP) is predominantly expressed in hepatocytes, maintaining bile salt homeostasis and serving as a receptor for hepatitis B virus (HBV). hNTCP expression is downregulated during hepatocel...
The Rac1-PAK1-Arp2/3 signaling axis regulates CHIKV nsP1-induced filopodia and optimal viral genome replication [0.03%]
Rac1-PAK1-Arp2/3信号轴调控CHIKV nsP1诱导的丝状伪足及最佳病毒基因组复制
Olivier Aïqui-Reboul-Paviet,William Bakhache,Eric Bernard et al.
Olivier Aïqui-Reboul-Paviet et al.
Alphavirus infection induces dramatic remodeling of host cellular membranes, producing filopodia-like and intercellular extensions. The formation of filopodia-like extensions has been primarily assigned to the replication protein nsP1, whic...
How structural biology has changed our understanding of icosahedral viruses [0.03%]
结构生物学如何改变了我们对二十面体病毒的认识
Mauricio Comas-Garcia
Mauricio Comas-Garcia
Cryo-electron microscopy and tomography have allowed us to unveil the remarkable structure of icosahedral viruses. However, in the past few years, the idea that these viruses must have perfectly symmetric virions, but in some cases, it migh...
Aaron E Lin,Emily V Mesev,Jared E Toettcher et al.
Aaron E Lin et al.
Though interferons (IFNs) were once heralded as panaceas to numerous diseases, how cells decode varying IFN stimuli and subsequently produce (in)appropriate signaling remain unclear. Our labs recently engineered novel erythropoietin recepto...
Epstein-Barr virus replication within differentiated epithelia requires pRb sequestration of activator E2F transcription factors [0.03%]
EB病毒复制需要E2F转录因子活化剂与视网膜母细胞瘤蛋白结合以分化上皮组织
Danielle L Schaal,Akajiugo A Amucheazi,Sarah C Jones et al.
Danielle L Schaal et al.
Epstein-Barr virus (EBV) co-infections with human papillomavirus (HPV) have been observed in oropharyngeal squamous cell carcinoma. Modeling EBV/HPV co-infection in organotypic epithelial raft cultures revealed that HPV16 E7 inhibited EBV p...
Elucidating the molecular properties and anti-mycobacterial activity of cysteine peptidase domain of D29 mycobacteriophage endolysin [0.03%]
D29噬菌体溶源酶半胱氨酸肽酶结构域的分子特性及其抗结核分枝杆菌活性研究
Rutuja Gangakhedkar,Vikas Jain
Rutuja Gangakhedkar
Emergence of antibiotic resistance in pathogenic Mycobacterium tuberculosis (Mtb) has elevated tuberculosis to a serious global threat, necessitating alternate solutions for its eradication. D29 mycobacteriophage can infect and kill several...