Genetic absence of PD-L1 does not restore CD8+ T cell function during respiratory virus infection and delays virus clearance
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A key mediator of T cell impairment during respiratory virus infection is the inhibitory receptor PD-1. PD-1 is induced on T cells following antigen exposure, whereas proinflammatory cytokines upregulate the ligands PD-L1 and PD-L2. Respiratory virus infection... ...