Identification of an uncharacterized protein as a novel regulator of Giardia lamblia virus (GLV) infection in Giardia duodenalis [0.03%]
鉴定一种未表征蛋白为调节贾第鞭毛虫病毒(GLV)感染十二指肠内变形虫的新型调节剂
Zhiteng Zhao,Lili Cao,Jianqi Yuan et al.
Zhiteng Zhao et al.
Giardia duodenalis (G. duodenalis) is a prevalent intestinal protozoan parasite responsible for causing diarrhea, particularly in children and travelers. Although many infections are asymptomatic, they can result in severe malnutrition and ...
Multimodal characterization of the responsiveness of eight hepatitis D virus genotype isolates to interferon-alpha treatment [0.03%]
八种基因型HDV分离株对干扰素-α治疗反应性的多模式表征
Yibo Ding,Qiudi Li,Yunlu Sha et al.
Yibo Ding et al.
Chronic hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis. Although humans produce 12 subtypes of interferon-alpha (IFN-α), IFN-α2a has been the only commonly used treatment against HDV. Previously, we c...
Mutation in enterovirus 71 nonstructural protein 3A increases genome replication fidelity and exhibits attenuated virulence in mice [0.03%]
肠道病毒71型非结构蛋白3A突变体可增加基因组复制保真度并降低其在小鼠体内致病力
Fang Yu,Dongyan Xiong,Yao Zhong et al.
Fang Yu et al.
Increasing numbers of studies have highlighted the important implications of the replication fidelity of RNA viruses for virus replication, pathogenesis, and the development of antiviral drugs and live-attenuated vaccines. However, most of ...
Discovery of a novel double-stranded DNA virus associated with ant labial gland disease reveals its long-term interaction with ants [0.03%]
一种新型双链DNA病毒与蚁唇腺病相关并揭示其长期相互作用
Shengqiang Jiang,Liangliang Zhang,Xingyu Guo et al.
Shengqiang Jiang et al.
Large double-stranded DNA (dsDNA) viruses have been shown to have a wide host range in insects. However, their infection in ants has not yet been described. In this study, we report the identification of a novel filamentous virus, Camponotu...
Identification of clinical and virological correlates associated with influenza A candidate vaccine virus (CVV) attenuation in a ferret model [0.03%]
基于雪貂模型的候选疫苗株弱毒化相关的临床和病毒学特征分析
Claudia Pappas,Nicole Brock,Jessica A Belser et al.
Claudia Pappas et al.
Influenza A viruses continuously circulate among avian and swine species, posing a persistent threat to public health. The development of influenza candidate vaccine viruses (CVVs) plays a pivotal role in the global strategy for influenza p...
The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infection [0.03%]
巨细胞病毒裂解感染活化STING信号通路的BTK-DDX41轴
Vargab Baruah,Christine M O&#x;Connor
Vargab Baruah
The innate immune response is the first line of defense against invading pathogens, including the betaherpesvirus human cytomegalovirus (CMV). The host's innate response acts as the first line of defense, and CMV, like other viruses, has co...
Functional and structural insights into HCMV terminase accessory proteins pUL77 and pUL93 [0.03%]
HCMV末端酶辅助蛋白pUL77和pUL93的功能和结构见解
C Gourin,F Di Meo,C Delmon et al.
C Gourin et al.
Human cytomegalovirus (HCMV) is a significant cause of morbidity and mortality in immunocompromised and congenitally infected patients. Current antiviral therapies, primarily targeting the viral DNA polymerase, are limited by toxicity and r...
Dual regulatory role of hsa-miR-122b-5p in chikungunya virus infection via interaction with CHIKV 3'-UTR and HDAC4 modulation [0.03%]
hsa-miR-122b-5p通过与CHIKV 3 '-UTR和组蛋白脱乙酰基酶4调节在登革病毒感染中的双功能作用
Priyanshu Srivastava,Nimisha Mishra,Sunil Kumar Dubey et al.
Priyanshu Srivastava et al.
Establishment of a viral infection in the host involves complex interactions between the virus and the host. The present study was undertaken to evaluate one such interaction between a host microRNA (miRNA) with both the virus and its cellu...
Apobec3 shows rapid evolution in house mouse subspecies and unusual hypermutation patterns of endogenous mouse mammary tumor viruses [0.03%]
Apobec3在小家鼠亚种中表现出快速进化以及内源性小鼠乳腺肿瘤病毒异常的超突变模式
Esther Shaffer,Guney Boso,Reza Sadjadpour et al.
Esther Shaffer et al.
Apobec3 (A3, apolipoprotein B editing complex 3) is a cytidine deaminase with broadly antiretroviral activity. A3 is packaged in virions and converts cytidines to uracil (C > U) in viral minus-strand DNA during reverse transcription, result...
3A and 2B proteins of SVA play chess game with host restriction factor DDX23 by apoptotic pathway [0.03%]
SVA病毒的3A和2B蛋白与宿主限制因子DDX23通过凋亡途径进行“国际象棋”博弈
Jie Li,Haicheng Lin,Yi Zhou et al.
Jie Li et al.
Senecavirus A (SVA) is an emerging porcine pathogen that poses a significant threat to the global swine industry and has become an obstacle to its sustainable development. DEAD-box helicase 23 (DDX23), an RNA helicase, is increasingly recog...