Convergent evolution in nucleocapsid facilitated SARS-CoV-2 adaptation for human infection [0.03%]
核衣壳趋同进化促进SARS-CoV-2适应人类感染
Kumari G Lokugamage,Yiyang Zhou,R Elias Alvarado et al.
Kumari G Lokugamage et al.
During the early stages of the COVID-19 pandemic, several SARS-CoV-2 variants of concern (VOCs) independently acquired mutations in the highly variable 203-205 amino acid region of the nucleocapsid (N) protein including R203K + G204R (found...
Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response [0.03%]
直接药理学激活AMPK通过减少脂质代谢、恢复自噬流量和I型IFN反应来抑制粘膜SARS-CoV-2感染
Andrea Cottignies-Calamarte,Flora Marteau,Feifan He et al.
Andrea Cottignies-Calamarte et al.
AMP-activated protein kinase (AMPK) plays a central role in regulating cell energy balance. When activated, AMPK suppresses energy-consuming pathways, such as lipid and protein synthesis, while increasing nutrient availability through the a...
Engineering a recombination-resistant live attenuated vaccine candidate with suppressed interferon antagonists for PEDV [0.03%]
通过抑制干扰素拮抗物工程设计出一种防止猪流行性腹泻病毒(PEDV)的重组抵抗型活减毒疫苗候选株
Mingde Liu,Bikash Aryal,Xiaoyu Niu et al.
Mingde Liu et al.
Porcine epidemic diarrhea virus (PEDV) is a deadly coronavirus (CoV) for neonatal piglets, and no effective vaccine is available. Live attenuated vaccines (LAVs) show promise, but risks of recombination and reversion to virulence hinder the...
High antigen burden drives CD8+ T cell dysfunction in a mouse model of chronic hepatitis B virus infection [0.03%]
高抗原负荷驱动慢性乙肝病毒感染小鼠模型中CD8⁺T细胞功能障碍
Catherine Rexhouse,Jacob T Bailey,Safiehkhatoon Moshkani et al.
Catherine Rexhouse et al.
Chronic hepatitis B virus (HBV) infection is characterized by dysfunctional HBV-specific CD8+ T cell responses that contribute to viral persistence. Understanding the mechanisms behind this dysfunction is necessary to develop effective immu...
African swine fever virus infection enhances CD14-dependent phagocytosis of porcine alveolar macrophages to promote bacterial uptake and apoptotic body-mediated viral transmission [0.03%]
非洲猪瘟病毒感恶化猪肺泡巨噬细胞CD14依赖性吞噬作用以促进细菌内吞和凋亡小体介导的病毒传播
Fengyang Shi,Zhen Xu,Peng Gao et al.
Fengyang Shi et al.
African swine fever virus (ASFV) is an economically devastating pathogen that can cause fatal infections in both domestic pigs and wild boar, with monocytes and macrophages as its target cells. For macrophages, phagocytosis is a fundamental...
IFIT3 RNA-binding activity promotes influenza A virus infection and translation efficiency [0.03%]
IFIT3的RNA结合活性促进流感病毒A型感染及翻译效率
Owen M Sullivan,Daniel J Nesbitt,Grace A Schaack et al.
Owen M Sullivan et al.
Host cells produce a vast network of antiviral factors in response to viral infection. The interferon-induced proteins with tetratricopeptide repeats (IFITs) are important effectors of a broad-spectrum antiviral response. In contrast to the...
Replication-deficient whole-virus vaccines against cytomegalovirus induce protective immunity in a guinea pig congenital infection model [0.03%]
无复制型全病毒疫苗通过 Guinea Pig 模型小鼠先天性感染模型诱导巨细胞病毒免疫反应
Mark R Schleiss,Claudia Fernández-Alarcón,Craig J Bierle et al.
Mark R Schleiss et al.
Vaccines are needed to prevent congenital human cytomegalovirus (HCMV) infections. This study used the guinea pig cytomegalovirus (GPCMV) model to examine replication-deficient whole-virus vaccines for protection against maternal viremia an...
Immunogenicity of NSDV GP38 and the role of furin in GP38 proteolytic processing [0.03%]
NSDV GP38的免疫原性及其在GP38蛋白酶处理中的作用
Caroline Bost,Filipe Tomaz,Luna C Schmacke et al.
Caroline Bost et al.
Nairobi sheep disease virus (NSDV) is a tick-borne orthonairovirus, which is genetically related to Crimean-Congo hemorrhagic fever virus (CCHFV), and causes severe hemorrhagic gastroenteritis in infected sheep. CCHFV GP38, a cleavage produ...
Monotherapy with antibody 1C3 partially protects Ebola virus-exposed macaques [0.03%]
用单克隆抗体1C3治疗部分保护埃博拉病毒暴露的恒河猴
Gabriella Worwa,Carl W Davis,Sarah E Klim et al.
Gabriella Worwa et al.
A cocktail of human monoclonal antibodies 1C3 and 1C11 previously protected macaques from a lethal exposure to either Ebola virus (EBOV) or Sudan virus (SUDV). 1C3 is of particular interest because its paratope strongly binds with unique st...
The furin cleavage site is required for pathogenesis, but not transmission, of SARS-CoV-2 [0.03%]
furin位点对SARS-CoV-2的致病性是必需的，但对其传播性不是必需的
Angelica L Morgan,Michelle N Vu,Yiyang Zhou et al.
Angelica L Morgan et al.
The SARS-CoV-2 spike, key to viral entry, has two features that differentiate it from other sarbecoviruses: the presence of a furin cleavage site (FCS; PRRAR sequence) and an extended S1/S2 loop characterized by an upstream QTQTN amino acid...