The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women [0.03%]
Nef在南非女性体内促进HIV复制型贮存库长期存在的作用研究
Sherazaan D Ismail,Shorok Sebaa,Bianca Abrahams et al.
Sherazaan D Ismail et al.
HIV-1 Nef mediates immune evasion and viral pathogenesis in part through the downregulation of cell surface cluster of differentiation 4 (CD4) and major histocompatibility complex class I (MHC-I) on infected cells. While the Nef function of...
Enterovirus C recombination groups: RNA sequence similarity and the viral polymerase underpin sexual replication mechanisms [0.03%]
肠病毒C重组群：RNA序列相似性和病毒聚合酶决定了其性复制机制
Evan M Okolovitch,Vishnu Govindarajan,Refugio Robles-Sikisaka et al.
Evan M Okolovitch et al.
Enteroviruses frequently recombine with one another in nature; however, it is unclear how viral replication machinery can distinguish between related and unrelated partners during recombination. We hypothesize that viral RNA recombination i...
CD317 functions as a key antiviral factor in human herpesvirus 6 (HHV-6) infection [0.03%]
CD317在人第六型疱疹病毒感染中发挥关键的抗病毒作用
Xianyi Xu,Minmin Song,Xin Zhang et al.
Xianyi Xu et al.
CD317, an interferon-stimulated gene, is known for its role in inhibiting the release of various enveloped viruses from infected cells. However, its function can vary, as it also promotes infection in certain contexts, such as with human cy...
CypA inhibits respiratory syncytial virus (RSV) replication by suppressing glycolysis through the downregulation of PKM2 expression [0.03%]
CypA通过下调PKM2的表达抑制糖酵解从而抑制呼吸道合胞病毒(RSV)的复制
Jing Zhang,Miao Li,Jing Cheng et al.
Jing Zhang et al.
The "Warburg effect," a type of metabolic reprogramming characterized by enhanced glycolysis even in the presence of oxygen, is frequently observed in tumor cells and has also been detected in cells infected with viruses. Our study demonstr...
METTL3 regulates PRRSV replication by suppressing interferon beta through autophagy-mediated IKKε degradation [0.03%]
METTL3通过自噬介导的IKKε降解抑制干扰素β从而调控PRRSV复制
Yunyun Zhai,Lucai Wang,Lijie Lv et al.
Yunyun Zhai et al.
Methyltransferase-like-3 (METTL3)-mediated N6-methyladenosine (m6A) modification of messenger RNAs plays a pivotal role in regulating innate immune responses, either promoting or combating virus replication. However, the biological function...
The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection [0.03%]
SHFV的nsp2和核衣壳蛋白将G3BP1募集到病毒复制部位，但感染不会诱导应激颗粒形成
Ayisha A Lavender,Oreoluwa Solanke,Hsin-Yao Tang et al.
Ayisha A Lavender et al.
Stress granules (SGs) are dynamic, cytoplasmic foci that form in response to environmental stresses, including viral infections, and function to restore cellular homeostasis by regulating mRNA translation, storage, and decay. To inhibit SG ...
Zika virus non-structural protein NS2A mediated endoplasmic reticulum stress through interacting with Sarco/endoplasmic reticulum Ca2+-ATPase 2 [0.03%]
蚊媒病毒Zika病毒NS2A蛋白通过与SERCA2相互作用诱导内质网应激响应
Shan Wang,Shanshan Tang,Yuxin Zhou et al.
Shan Wang et al.
Zika virus (ZIKV) infection of neuronal cells leads to endoplasmic reticulum (ER) stress, which is one of the key causes of neuronal damage. However, how ZIKV mediates ER stress has not been fully understood. Here, we observed that ZIKV inf...
Diversity and evolutionary history of RNA viruses among different horseshoe crab species [0.03%]
不同种类鲎中的rna病毒的多样性及其进化历史研究
Yu-Hua Qi,Zhuang-Xin Ye,Ke-Hui Feng et al.
Yu-Hua Qi et al.
Horseshoe crabs (Xiphosura: Limulidae) are the sole surviving species of the class Merostomata, with only four extant species remaining today. Recent advances in metagenomic next-generation sequencing have unveiled a vast diversity of RNA v...
Molecular mechanism of potently neutralizing human monoclonal antibodies against severe fever with thrombocytopenia virus infection [0.03%]
人抗西尼罗样病毒单克隆抗体的超强中和作用及其分子机制研究
Chuansong Quan,Kaixiao Nie,Dezhen Ma et al.
Chuansong Quan et al.
Although severe fever with thrombocytopenia syndrome (SFTS) was first described in China in 2009, the case fatality rate remains >40% among patients with multi-organ failure. To date, no antivirals specifically targeting SFTSV have been app...
Efficacy of oncolytic virus in the treatment of intermediate-to-advanced solid tumors: a systematic review and meta-analysis [0.03%]
溶瘤病毒治疗中晚期实体肿瘤疗效的系统评价和meta分析
Jin-Zhou Xu,Jian-Xuan Sun,Chen-Qian Liu et al.
Jin-Zhou Xu et al.
This meta-analysis assessed oncolytic virus therapy's efficacy for intermediate-to-advanced solid tumors. We systematically searched PubMed, Cochrane Library, and Embase databases until March 6, 2025. Our review included 87 studies, involvi...