Novel insights into immune checkpoints in HIV/SHIV infection: from SHIVSF162P3-infected elite controllers to therapeutic strategy [0.03%]
HIV/SHIV感染中的免疫检查点的新见解：从SHIVSF162P3感染的功能性治愈者到治疗策略
Yuting Sun,Chenbo Yang,Peiwen Liu et al.
Yuting Sun et al.
During chronic HIV-1 infection, the upregulation of immune checkpoints (ICs) on lymphocytes contributes to persistent immune dysfunction, T-cell exhaustion, and inadequate virological control, highlighting the potential role of ICs in HIV f...
ICAM-1-mediated Src signaling pathway plays a pivotal role in encephalomyocarditis virus entry [0.03%]
ICAM-1介导的Src信号途径在肠病毒68型感染中发挥重要作用
Ruiya Lian,Xueer Dou,Na Wang et al.
Ruiya Lian et al.
Encephalomyocarditis virus (EMCV), a potential zoonotic pathogen with a broad host range, has been reported to enter cells via caveolin-mediated endocytosis (CavME), a process initiated by caveolae detachment from the plasma membrane. Howev...
PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation [0.03%]
PEDV Nsp14通过诱导线粒体自噬介导MAVS降解来拮抗宿主天然免疫并促进病毒增殖
Lei Yang,Qisheng Qian,Yan-Gang Sun et al.
Lei Yang et al.
Porcine epidemic diarrhea virus (PEDV) leads to a high mortality in neonatal piglets and causes serious harm to the global swine industry. PEDV has been shown to exploit diverse strategies for antagonism of host innate immunity and promotio...
Targeting papillomavirus infections: high-throughput screening reveals an effective inhibitor of cutaneous β-HPV types [0.03%]
针对乳头瘤病毒的药物筛选发现有效的皮肤型β-HPV感染抑制剂
Ruslan Ibragimov,Sofiya Babok,Elina Lototskaja-Perepelenko et al.
Ruslan Ibragimov et al.
Cutaneous and mucosal human papillomaviruses (HPVs) are implicated in the development of various cancers. To date, there are no HPV-specific antivirals, and vaccines designed for mucosal HPV types are ineffective against cutaneous HPV varia...
Differential decreases in various HIV DNA regions and HIV transcripts after ART initiation during chronic infection [0.03%]
启动抗逆转录病毒治疗后慢性人类免疫缺陷病毒(HIV)感染患者外周血单个核细胞中游离和2-LTR环状DNA以及RNA的动态变化
Julie Janssens,Cordelia Isbell,Sun Jin Kim et al.
Julie Janssens et al.
HIV-transcribing cells persist on ART and likely contribute to inflammation as well as the viral rebound that occurs after stopping ART. However, it is unclear how ART start time and prolonged time on ART affect the clearance of cells expre...
Phylogenetic analysis of H5N1 influenza viruses isolated from dairy cattle in Texas in December 2024 [0.03%]
2024年德克萨斯州从乳畜牛中分离的H5N1流感病毒的系统发育分析
Sangam Kandel,Lavanya Babujee,Lizheng Guan et al.
Sangam Kandel et al.
Role of complementary-sense genes and intergenic region of beet curly top virus in intermolecular recombination frequency upon local infection in plants [0.03%]
互补基因和双链RNA在植物局部感染中参与介导属间重组的机制研究
Omid EIni,Zahra Shoaei,Nadine Schumann et al.
Omid EIni et al.
Intermolecular recombination is a critical process in the evolution of plant viruses, including geminiviruses. In this study, we investigated the impact of geminiviral factors on the homologous recombination frequency (HRF) in a model syste...
Epstein-Barr virus-infected tonsillar marginal zone B cells in vivo as a precursor for immunosuppression-related B-cell lymphoma [0.03%]
EB病毒感染的咽部边缘区B细胞是免疫抑制相关的B细胞淋巴瘤的前体细胞
Charles Torgbor,David A Thorley-Lawson,Ann M Moormann
Charles Torgbor
The germinal center model (GCM) of Epstein-Barr virus (EBV) persistence in humans proposes that EBV infects and drives naïve B cells through the GC to establish a quiescent lifelong persistent infection in memory B cells. EBV causes severa...
A novel replication-deficient FCV vaccine provides strong immune protection in cats [0.03%]
一种新型的FCV复制缺陷疫苗可以有效保护猫免受感染
Wuchang Heng,Dan Zang,Ruiyu Li et al.
Wuchang Heng et al.
Feline calicivirus (FCV) belongs to the family Caliciviridae, which includes important animal and human pathogens such as human norovirus and rabbit hemorrhagic disease virus. The fast evolution and great diversity of FCV make it highly dif...
Untangling the causes of geographical disparities in the clinical outcome of HTLV-1 infection: a critical perspective on the contribution of viral genetic diversity [0.03%]
解开人类T细胞白血病病毒Ⅰ型感染临床结局地理差异之谜：病毒遗传多样性的影响不容忽视
Thomas Duchateau,Philippe V Afonso,Chloé Journo
Thomas Duchateau
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) is the etiological agent of two major diseases, adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), as well as various other inf...