Activation of the HPV16 late promoter by viral E2 and cellular BRD4 and ZC3H4 proteins [0.03%]
HPV16晚期启动子受病毒E2蛋白及细胞BRD4和ZC3H4蛋白的活化
Janis Renner,Karsten Boldt,Andreas Wieland et al.
Janis Renner et al.
High-risk human papillomaviruses (HPV), particularly HPV16, are major causes of anogenital and oropharyngeal cancers. The HPV late promoter, P670 in the case of HPV16, is activated upon host cell differentiation and drives the expression of...
Essential function of the integrator complex in Kaposi's sarcoma-associated herpesvirus lytic replication [0.03%]
整合酶复合体在卡波西肉瘤相关疱疹病毒裂解复制中的基本功能
Amy Nguyen,Tianqi Li,Conner Traugot et al.
Amy Nguyen et al.
The integrator complex (INT) is an essential regulator of RNA biogenesis across evolution. Most current findings describe INT's function in states of equilibrium, presenting a research gap in INT's role in dynamic states, such as in infecti...
Deciphering the membrane topology of the pestiviral non-structural protein 4B (NS4B) [0.03%]
解读披膜病毒非结构蛋白4B(NS4B)的拓扑结构
S Höppner,O Isken,N Tautz
S Höppner
Pestiviruses like bovine viral diarrhea virus and other members of the family Flaviviridae form replication complexes consisting of viral non-structural and cellular proteins at rearranged intracellular membranes. Despite the pivotal roles ...
Seneca Valley virus 3C protease targets TRIM32 for cleavage to antagonize its antiviral effects [0.03%]
森卡谷病毒3C蛋白酶通过切割TRIM32来拮抗其抗病毒作用
Jingjing Yang,Zijian Li,Ruiyi Ma et al.
Jingjing Yang et al.
The Seneca Valley virus (SVV), a newly emerged virus within the Picornaviridae family, causes porcine idiopathic vesicular disease, imposing substantial economic costs to the global pork industry. However, the molecular mechanisms underlyin...
DDX54 drives ALKBH5-mediated demethylation of selected transcripts to suppress interferon antiviral response [0.03%]
DDX54通过驱动ALKBH5对特定mRNA去甲基化来抑制I型干扰素的抗病毒反应
Hao-Yu Sun,Xiu-Ying Gong,Zi-Ling Qu et al.
Hao-Yu Sun et al.
DEAD-box (DDX) proteins are currently reported to shape host innate immunity by regulation of N6-methyladenosine (m6A) modification of transcripts for host factors involved in antiviral signaling. However, which DDX proteins are involved in...
Retinal transduction profiling of diverse AAV serotypes via intravitreal injection [0.03%]
玻璃体腔注射后AAV衣壳在视网膜中的转导谱分析
Tianlu Zhang,Fei Wang,Yang Wu et al.
Tianlu Zhang et al.
Optimizing adeno-associated virus (AAV) capsid and dosing selection is critical for the clinical translation of retinal gene therapy. This study aims to provide a comprehensive reference by comparing the transduction efficiency, cellular tr...
Alyson A Kelvin,Pari H Baker,Sourish Ghosh et al.
Alyson A Kelvin et al.
The mammary gland is an essential organ for milk production, providing essential immune and nutritional support to offspring and supplying dairy products for human consumption. In both humans and animals, the lactating mammary gland is susc...
Functional orthogonality of parvoviral phospholipase A2 domains in adeno-associated virus transduction [0.03%]
肠道病毒A2蛋白酶结构域在腺相关病毒转导中的功能正交性
Joshua A Hull,Robert M Fusco,Jeffery Tan et al.
Joshua A Hull et al.
Dependoparvoviruses, which belong to the family Parvoviridae, are being developed as viral vectors for gene transfer. Notably, different adeno-associated viral (AAV) serotype capsids have been utilized to generate pseudotyped recombinant ve...
Increased infectivity of human cytomegalovirus strain TB40/E conferred by variants of the envelope glycoprotein UL128 and the regulatory protein IE2 [0.03%]
包膜糖蛋白UL128变异体和调控蛋白IE2赋予人类巨细胞病毒TB40/E毒株的传染性增强效应
Xuan Zhou,Linjiang Yang,Giorgia Cimato et al.
Xuan Zhou et al.
Human cytomegalovirus (HCMV) infects various cell types in its human host, and this broad tropism plays a vital role in viral transmission, dissemination, and pathogenesis. HCMV strains differ in their ability to infect and replicate in dif...
Heat shock protein A1L restricts influenza A virus by ubiquitination of NA [0.03%]
热休克蛋白A1L通过泛素化NA限制甲型流感病毒入侵
Yan Yan,Jianan Xu,Zhen Chen et al.
Yan Yan et al.
Neuraminidase (NA) protein of influenza A virus (IAV), a tetrameric envelope glycoprotein critical for viral release and spread, has well-characterized enzymatic functions but poorly resolved host-pathogen interactions. However, host factor...