SARS-CoV-2 Nsp15 endoribonuclease subverts host defenses to enhance viral fitness in lung cells [0.03%]
SARS-CoV-2 Nsp15 内切核糖核酸酶劫持宿主防御以增强肺细胞内病毒适应度
Xiang Chi,Xueying Liang,Kishore Vaddadi et al.
Xiang Chi et al.
Coronaviruses encode nonstructural protein 15 (Nsp15), a conserved endoribonuclease (EndoU) known to suppress host antiviral responses. It is imperative to understand the role of Nsp15/EndoU during severe acute respiratory syndrome coronavi...
E2-based mRNA vaccine encapsulated in lipid nanoparticles protects pigs against classical swine fever virus [0.03%]
基于E2蛋白的mRNA疫苗包裹在脂质纳米颗粒中可保护猪免受经典猪瘟病毒感染
Jingyi Liu,Yingju Xia,Chuanwen Tian et al.
Jingyi Liu et al.
Classical swine fever (CSF), caused by the classical swine fever virus (CSFV), remains a significant threat to the global pig industry. Recent advances in mRNA vaccines offered a promising platform for combating CSFV. In this study, we desi...
Inadequate immune response to inactivated COVID-19 vaccine among older people living with HIV: a prospective cohort study [0.03%]
HIV阳性老年人接种新冠灭活疫苗后的免疫应答欠佳：前瞻性队列研究
Hangjie Zhang,Xuan Deng,Rongrong Dai et al.
Hangjie Zhang et al.
The concerns exist regarding the inadequate immune response to inactivated COVID-19 vaccines in some people living with HIV (PLWH). A prospective cohort study was conducted across four regions of Zhejiang, China. Both PLWH and healthy contr...
Discovery, phylogenetic, and comparative genomic analysis of novel avian gammacoronaviruses identified in feral pigeons (Columba livia domestica) [0.03%]
家岩鸽新发γ冠状病毒的发现、分类及比较基因组学分析
Mohamed E El Zowalaty,Louis J Taylor,Yongwoo Son et al.
Mohamed E El Zowalaty et al.
The COVID-19 pandemic caused by SARS-CoV-2 has intensified efforts to identify emerging coronaviruses (CoVs) across diverse hosts. Spillover events, where CoVs transition from wildlife reservoirs to other species, can lead to infections wit...
New insights into temperature-impacted mycovirus-fungus interactions regulated by a microRNA in Lentinula edodes [0.03%]
基于微小核糖核酸的温度影响香菇病毒-菌丝相互作用的新见解
Chun-Xi Liu,Meng-Pei Guo,Jun-Zhuo Zhou et al.
Chun-Xi Liu et al.
The onset of symptoms in virus-infected mushrooms merits investigation. In this study, the influence of heat stress (HS) on the interaction between Lentinula edodes mycovirus HKB (LeV) and its mushroom host, Lentinula edodes, was explored, ...
Co-infection of Helicobacter pylori with Epstein-Barr virus in gastric organoids enhances cell proliferation and morphogenesis [0.03%]
幽门螺杆菌与埃可病毒共感染胃器官类器官增强细胞增殖和形态发生
Lina Liu,Caixia Zhu,Shuxin Zhang et al.
Lina Liu et al.
Helicobacter pylori (H. pylori) is a key cause of chronic inflammation and gastric cancer, and Epstein-Barr virus (EBV) also contributes to gastric tumorigenesis. However, the role of EBV co-infection in H. pylori-related cancers remains un...
HSV-1 progeny production by individual human keratinocytes spans three orders of magnitude [0.03%]
人角质形成细胞产生的HSV-1子代病毒数量相差三个数量级
Vincent P Villani,Jason A Espinoza,Nir Drayman
Vincent P Villani
A fundamental property of viruses is their burst size-the amount of progeny produced during one round of infection. Herpes simplex virus 1 (HSV-1) is a widespread pathogen, causing significant morbidity in the human population worldwide. De...
Ibrutinib inhibits the replication of multiple poxviruses by targeting the Bruton tyrosine kinase [0.03%]
依布替尼通过靶向布鲁顿酪氨酸激酶抑制多种痘病毒的复制
Kang Niu,Xiru Wang,Qiwei Jiang et al.
Kang Niu et al.
The recent surge in global monkeypox (mpox) outbreaks highlights the critical need for developing antiviral agents targeting orthopoxvirus infections. Ibrutinib, a selective Bruton tyrosine kinase (BTK) inhibitor initially approved by the F...
Cryo-EM structure of the Seneca Valley virus A-particle and related structural states [0.03%]
森卡谷病毒A粒子的低温电子显微镜结构及相关结构状态
Rosheny Kumaran,Nadishka Jayawardena,Kuan-Lin Chen et al.
Rosheny Kumaran et al.
Picornavirus cell entry requires a series of capsid protein conformational changes leading to genome uncoating. For enteroviruses, receptor binding triggers the transition from a full (F) capsid to an altered (A) particle before releasing i...
The leader of the capsid protein from Feline calicivirus must be palmitoylated and form oligomers through disulfide bonds for efficient viral replication [0.03%]
猫杯状病毒衣壳蛋白领导肽的棕榈酰化及通过二硫键形成寡聚体对于有效病毒复制是必需的
Yoatzin Peñaflor-Téllez,Jaury Gómez de la Madrid,Erick Ignacio Monge-Celestino et al.
Yoatzin Peñaflor-Téllez et al.
Feline calicivirus (FCV), a member of the genus Vesivirus and a model for studying members of the family Caliciviridae, has been used to understand the biology and viral replication of etiological agents of medical and veterinary importance...