Design, Synthesis, In Silico Profiling, and In Vitro Anticancer Assessment of Azine-Linked Thiazolo[3,2-a]benzimidazoles as CDK2-Directed Therapeutic Candidates [0.03%]
作为CDK2导向治疗候选药物的偶联氨基噻唑并[3,2-a]苯并咪唑的设计、合成、计算机模拟谱性分析及体外抗癌评估研究
Mohamed S M Ahmed,Sayed M Riyadh,Mohammad Alhilal et al.
Mohamed S M Ahmed et al.
A series of unsymmetrical azine-linked thiazolo[3,2-a]benzimidazole derivatives (4a-r) was synthesized and structurally characterized. Density functional theory (DFT) calculations, including frontier molecular orbital (FMO) analysis and glo...
A LAT1-Compatible, Leadlike Tyrosine-Naphthoquinone Conjugate With Anticancer Activity [0.03%]
一种具有抗癌活性的LAT1兼容性的、类药性色氨酸-萘醌缀合物
Austin Seymour,Christian Peterson,Raymond Osafo et al.
Austin Seymour et al.
A L-type amino acid transporter 1 (LAT1)-compatible, anticancer-active tyrosine-naphthoquinone (NQ) conjugate was successfully developed. The conjugate was designed to exploit LAT1 overexpression in cancers with the goal of achieving select...
Novel Antioxidant Quinazoline Sulfonamide Derivatives Acting Through NQO1 Induction and Their Radiation-Based Biodistribution Studies [0.03%]
一种通过NQO1诱导发挥抗氧化作用的喹唑啉磺酰胺衍生物及其基于辐射的生物分布研究
Mostafa M Ghorab,Aiten M Soliman,Maureen Higgins et al.
Mostafa M Ghorab et al.
A series of quinazoline derivatives 5-19 bearing a benzenesulfonamide moiety and different acetamide side chains, including aromatic and heterocyclic groups, were designed, synthesized and confirmed structurally by microanalytical and spect...
Unlocking the Anticancer Potential of New Spirooxindoles via p53-MDM2/MDMX Dual Inhibition: In Vitro and In Silico Assessments [0.03%]
通过p53-MDM2/MDMX双抑制解除新型螺氧吲哚类化合物的抗癌潜力：体外和计算机模拟评估
Haidy H El-Zoheiry,Rehab F Ahmed,Mahmoud S Elkotamy et al.
Haidy H El-Zoheiry et al.
Blocking the p53-MDM2 and/or p53-MDMX protein-protein interaction (PPI) by small-molecule inhibitors has been tracked as a potentially effective cancer treatment approach. Herein, we present the discovery of a new series of spirooxindole-te...
Design and Synthesis of Bis-3,4-Dimethoxybenzene-Fibrate Derivatives as Potential Lipid-Lowering and Hepatoprotective Agents Based on the Principles of Structural Simplification and Bioisosterism [0.03%]
基于结构简化和生物电子等排原理设计合成的潜在降脂保肝剂双3,4-二甲氧基苯基-非诺酯类衍生物
Ling Ding,Yuyu An,Huizi Shangguan et al.
Ling Ding et al.
A series of bis-3, 4-dimethoxy-fibrate derivatives was designed using structural simplification and bioisosteric principles. The hypolipidemic effects of these compounds were initially evaluated in a Triton WR 1339-induced hyperlipidemic mo...
Thiazole-Semicarbazone Hybrids as Dual-Stage Inhibitors of Leishmania major Growth: Design, Synthesis, and Mechanistic Insights [0.03%]
噻唑半卡巴腙化合物作为沙氏利什曼原虫生长双靶标抑制剂的设计、合成及机理研究
Moataz A Shaldam,Haytham O Tawfik,Abdelrahman I Zain-Alabdeen et al.
Moataz A Shaldam et al.
As a neglected tropical disease, Leishmaniasis continues to pose a serious threat to world health, especially in areas with limited resources. There is a pressing need for safer and more effective antileishmanial drugs due to the limited ef...
Blueprint for Drug Repurposing Success: Foundational Concepts and Practical Framework [0.03%]
药物再利用成功的蓝图：基础概念和实用框架
Aayusree Ray,Shreya Dey,Debjeet Sur
Aayusree Ray
Drug repurposing involves identifying new therapeutic applications for existing clinically evaluated compounds. In contrast to conventional drug development, which typically spans over a decade and demands substantial financial investment, ...
Synthesis, Characterization, and Biological Evaluation of Aliphatic-Substituted Benzimidazole Derivatives: Induction of Apoptosis, Cell Cycle Arrest, and Molecular Docking in Breast Cancer Cells [0.03%]
脂肪族取代苯并咪唑衍生物的合成、表征及生物学评价：在乳腺癌细胞中诱导凋亡、细胞周期阻滞和分子对接研究
Murat Keser,Çisil Çamlı Pulat,Harika Atmaca et al.
Murat Keser et al.
A new series of aliphatic-substituted benzimidazole derivatives was synthesized and structurally characterized to evaluate their potential anticancer activity. Among the synthesized compounds, compound 4 exhibited the most potent cytotoxic ...
PTC-Assisted Chemoselective S-Alkylation of 5-Mercapto-1,3,4-Oxadiazol Derivative: Multi-Target Anticancer via EGFR, Telomerase, and Thymidylate Synthase Inhibition With Apoptosis Induction [0.03%]
基于PTC导向的化学选择性S-烷基化合成5-巯基-1,3,4-恶二唑衍生物及其抗癌活性研究
Asmaa Zakaria,Ahmed A Al-Karmalawy,Samia S Hawas et al.
Asmaa Zakaria et al.
Multi-target enzyme inhibition represents a promising strategy to overcome resistance and improve therapeutic outcomes in cancer therapy. In this study, a new series of 1,3,4-oxadiazole derivatives was synthesized and evaluated for cytotoxi...
Heteromerization, Biased Agonism, and Allosteric Modulation of G Protein-Coupled Receptors in Addiction: Mechanistic Insights and Therapeutic Implications [0.03%]
成瘾障碍中G蛋白偶联受体异聚化、偏向性激动和别构调节的机制及治疗意义
Khaled A Alhosaini,Mohammed M Alanazi,Ibrahim N Alsulaihim et al.
Khaled A Alhosaini et al.
G protein-coupled receptors (GPCRs) are core transducers of psychoactive drug action, shaping second messenger signaling, ion channel function, and neurotransmitter release in reward- and stress-related circuits. Despite decades of therapeu...