Seyedeh Toktam Ekrani,Tola Abdulsattar Faraj,Chnar Husam Taha et al.
Seyedeh Toktam Ekrani et al.
As the population ages, the prevalence of neurodegenerative disease, such as Parkinson's disease (PD) continues to grow and new and alternative treatment modalities will be required to deal with these issues. Peptoids are oligomers of N-sub...
Unveiling Remyelinating Properties of Roflumilast in CPZ-Induced Neuronal Demyelination in Mice [0.03%]
Roflumilast促少突胶质细胞髓鞘再生和线粒体保护作用及其机制研究
Ahmed S Kamel,Israa Sameh,Mohamed A Khattab et al.
Ahmed S Kamel et al.
Multiple sclerosis (MS) is a demyelinating disorder characterized by oligodendrocyte apoptosis, microglial activation at demyelination sites, with ROS production. These pathological processes are closely associated with phosphodiesterase-4 ...
Molecular Boomerangs Against Cancer: Design, Synthesis, Biological Evaluation, and In Silico Study of Novel Dual PARP-1/EGFR Inhibitors [0.03%]
用于治疗癌症的分子回力标的设计、合成、生物评估及计算机模拟研究：新型PARP-1/EGFR双靶点抑制剂
Haytham O Tawfik,Amr Tayel,Salma M Hefny et al.
Haytham O Tawfik et al.
A possible method for improving anti-cancer efficacy is the combination of the inhibition of epidermal growth factor receptor (EGFR) and poly (ADP-ribose) polymerase-1 (PARP-1). This work describes the rational design, synthesis, and comple...
Lead Discovery via Scaffold Refinement: Structure-Guided Optimization of 1,2,4-Triazolo[1,5-a]Pyrimidines as Potent Dual EGFR/CDK-2 Inhibitors Targeting Colorectal Carcinoma [0.03%]
基于结构的先导优化发现新型EGFR/CDK-2双靶点抑制剂类抗结直肠癌药物研究
Rowida Nasr,Hesham Haffez,Mohamed S Nafie et al.
Rowida Nasr et al.
A unique series of 1,2,4-triazolo[1,5-a]pyrimidine derivatives was designed and synthesized as potential dual inhibitors of EGFR and CDK-2 to circumvent drug resistance in colorectal cancer patients through multi-targeted therapy. When test...
Discovery of Novel 5-Substituted-4-Allyl-1,2,4-Triazoles as Potential Nonsteroidal Anti-Inflammatory Agents via Downregulation of iNOS Expression [0.03%]
通过下调iNOS表达发现新的抗炎非甾体化合物5-取代-4-烯丙基-1,2,4-三唑类化合物
Samar H Abbas,Asmaa S A Hammad,Dina M M H El-Kossi et al.
Samar H Abbas et al.
Inducible nitric oxide synthase (iNOS) is a key mediator of inflammatory signaling, and excessive iNOS-derived nitric oxide (NO) contributes to the pathology of multiple chronic inflammatory disorders. Herein, we report the design and synth...
Sustainable One-Pot Synthesis of Novel Triazolopyrimidine Derivatives as Selective CDK4 Inhibitors for Breast Cancer Therapy [0.03%]
一种可持续的一锅合成新型三唑并嘧啶衍生物的方法，该方法能够选择性地抑制CDK4，用于乳腺癌治疗。
Doaa A Elsayed,Wesam S Shehab,Maysa M Mohamed et al.
Doaa A Elsayed et al.
A sustainable and effective one-pot synthesis of new 4,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile derivatives was accomplished using Mn₃O₄ nanoparticles as a recyclable nanocatalyst under moderate and environmentally benign...
Santamarine Synergizes With Cisplatin via ROS/JNK Axis to Selectively Induce Apoptosis and DNA Damage in Oral Cancer Cells In Vitro [0.03%]
桑塔梅琳通过ROS / JNK轴与顺铂协同作用，选择性地在体外诱导口腔癌细胞凋亡和DNA损伤
Hsin-I Lu,Kuan-Liang Chen,Chung-Yi Chen et al.
Hsin-I Lu et al.
Santamarine (SAMA), a Michelia compressa-derived sesquiterpene lactone, exhibits ROS‑mediated anticancer activity; however, its potential mechanisms and synergy with cisplatin in oral cancer have not been explored. This study investigated ...
Oginni Gbenga Folorunsho,Queenie Fernandes,Ayo Oisagah Ezekiel et al.
Oginni Gbenga Folorunsho et al.
Nanobodies, also known as single-domain antibodies or Variable Heavy domain of Heavy chain antibody, are unique antibody fragments derived from camelid heavy-chain antibodies. Due to their small size, stability, and high specificity, nanobo...
Mesalamine in Treatment of Intestinal Inflammatory Diseases-Formulation-Driven Strategies for Targeted Colonic Therapy and Remission Maintenance [0.03%]
5-氨基水杨酸在肠道炎症性疾病治疗中的作用：结肠定位释药与缓解维持疗法中的药物剂型策略研究
Bijayananda Sahoo,Jitendra Patel
Bijayananda Sahoo
Mesalamine (5‑aminosalicylic acid, mesalazine, or 5‑ASA) remains a cornerstone therapy for mild‑to‑moderate ulcerative colitis because of its local anti‑inflammatory and antioxidant actions on the intestinal mucosa, and its clinical pe...
TRIM26-Mediated CBX6 Ubiquitination Triggers NETosis to Drive Bladder Cancer Tumor Growth via the CNPY2/NF-κB Signaling Pathway [0.03%]
TRIM26介导的CBX6泛素化通过CNPY2/NF-κB信号通路触发NETosis促进膀胱肿瘤生长
XiaoJuan Xie,ZhenZhen Li,TongTong Qiu et al.
XiaoJuan Xie et al.
Neutrophil extracellular traps (NETs) play a critical role in bladder cancer (BCa) progression, but the intrinsic molecular drivers within tumor cells that orchestrate NET formation remain largely unknown. This study aimed to investigate wh...