PKCδ-Drp1 Axis Mediates VIP-Induced Mitochondrial Fragmentation and Metabolic Crisis in Nasopharyngeal Carcinoma [0.03%]
Jingda Xu,Guanzheng Wu,Min Chen et al.
Jingda Xu et al.
In nasopharyngeal carcinoma, mitochondria often function abnormally. However, the precise signals that cause excessive mitochondrial division are still undefined. Levels of the neuropeptide Vasoactive Intestinal Peptide are altered in NPC t...
Artificial Intelligence in Drug Discovery and Development: Transforming Pharmaceutical Innovation [0.03%]
Mohd Shoab Ali,Taha Alqahtani,Humood Al Shmrany et al.
Mohd Shoab Ali et al.
Drug discovery remains a lengthy, costly, and high-risk endeavor, often requiring over a decade from target identification to clinical translation. Artificial intelligence (AI) is reshaping this paradigm by enabling more efficient and accur...
Targeting Alpha-Synuclein Aggregation With Chemical Chaperone IP-045: An Approach to Parkinson's Disease Therapy [0.03%]
Navpreet Kaur,Rimaljot Singh,Neelima Dhingra et al.
Navpreet Kaur et al.
Protein misfolding and aggregation of alpha-synuclein (α-syn) are central to Parkinson's disease (PD). Current therapies provide only symptomatic relief without addressing α-syn aggregation. Chemical chaperones such as 4-phenylbutyrate (4...
Cryptocaryone Exhibits ROS/MAPK-Dependent Antiproliferative and Apoptosis-Inducing Effects on Triple-Negative Breast Cancer Cells and Proof-of-Concept Breast Cancer Mouse Model [0.03%]
Ya-Ting Chuang,Wangta Liu,Tsu-Ming Chien et al.
Ya-Ting Chuang et al.
Omics' technologies have enabled clinicians to gain previously unprecedented insights into the molecular complexity and clinical heterogeneity of triple-negative breast cancer (TNBC). Increasingly it is being realized that TNBC does not res...
Cyclophosphamide Induces Autophagy-Dependent Ferroptosis Through Promoting ETNK1 Expression in Breast Cancer Cells [0.03%]
Jiacheng Shen,Aifeng Qiu,Xiaobing Liu et al.
Jiacheng Shen et al.
Breast cancer is the most common cancer in females worldwide, and the incidence rate in China has been increasing in recent decades. The treatment of breast cancer with cyclophosphamide (CTX) is one of the cornerstones of combination chemot...
Preparation of Aaptamine-Loaded Fusogenic Liposomes and Evaluation of Its Enhanced Antibacterial Activity Against MRSA [0.03%]
包合有aaptamine的融合型脂质体的制备及其对MRSA抗菌活性的研究
Tianjiao Geng,Guoqiang Hou,Yingqiu Liu et al.
Tianjiao Geng et al.
The global threat of methicillin-resistant Staphylococcus aureus (MRSA) necessitates the development of novel therapeutic strategies. Our previous work identified A7, a marine-derived aaptamine alkaloid, as a potential anti-MRSA agent. Howe...
Targeting the NLRP3 Inflammasome: Novel Inhibitors for Cardiovascular Diseases Management - A Narrative Review [0.03%]
针对NLRP3炎症小体的靶向作用：心血管疾病管理的新抑制剂——叙述性综述
Yomna S Momen
Yomna S Momen
The innate immune system is the first line of defense against pathogens and intracellular danger signals, providing a rapid nonspecific response to eliminate the infection and maintain tissue homeostasis. NLRP3 (NLR family pyrin domain cont...
Ferrocene-Pyrazole Hybrid Induces Ferroptosis and Metabolic Disruption in Pancreatic Cancer [0.03%]
铁焦宁-吡唑杂化物诱导胰腺癌细胞的铁死亡和代谢紊乱
Kuan Liu,Junhao Dai,Jianhua Wei et al.
Kuan Liu et al.
Drugs with multiple anticancer mechanisms have shown promising applications in tumor treatment. Herein, we synthesized a series of ferrocene-pyrazole hybrids (8-11) to assess their anti-pancreatic cancer activities. Among them, compound 11 ...
Design and Development of PLGA-PEG-FA Nanoparticles Encapsulating Noscapinoids for Receptor-Mediated Breast Cancer Treatment [0.03%]
基于受体介导的乳腺癌治疗的Noscapinoids载药PLGA-PEG-FA纳米粒的设计与制备研究
Namita Bhoi,Pradeep Kumar Naik
Namita Bhoi
Folate-conjugated PLGA-PEG nanocarriers have emerged as a promising strategy for targeted delivery of anticancer agents such as 9-bromo-noscapine (9-Br-Nos) for targeting of folate receptors, which are overexpressed in breast cancer cells. ...
Investigating the Therapeutic Potential of Cinnamic Acid in Vascular Dementia Through PARP1 Inhibition and Microglial M2 Polarization [0.03%]
通过PARP1抑制和小胶质细胞M2极化探究丁香酸在血管性痴呆治疗中的潜力研究
Jiao Li,Mingrong Song,Yifan Bu et al.
Jiao Li et al.
Vascular dementia (VD) is a cerebrovascular disease-associated cognitive disorder characterized by chronic neuroinflammation. Cinnamic acid (CA), a natural aromatic carboxylic acid, has been demonstrated to mitigate neurological dysfunction...