Neuroprotective Effect of Empagliflozin/Rivastigmine in Alzheimer's Disease Rat Model: Optimization of Multifaceted Mechanism of Action [0.03%]
恩格列净/石杉碱甲在阿尔茨海默病大鼠模型中的神经保护作用：多方位机制优化
Ebtsam S Abdel-Lah,Nashwa Hamad,Amira F Taha et al.
Ebtsam S Abdel-Lah et al.
This study assessed the neuroprotective potential of empagliflozin (EMPA) as antidiabetic drug on glucose metabolism, comparing it to rivastigmine (RIVA) as standard treatment for Alzheimer's disease (AD), and their combination. Male rats w...
Curcumin Alleviates Sepsis-Associated Acute Kidney Injury Potentially by Inhibiting Ferroptosis Through the ACSL4/GPX4 Signaling Pathway [0.03%]
姜黄素通过ACSL4/GPX4信号通路抑制铁死亡潜在地缓解脓毒症相关急性肾损伤
Lifeng Wang,Nannan Wu,Weidong Zhang et al.
Lifeng Wang et al.
This study aimed to investigate the protective effect of curcumin against sepsis-associated acute kidney injury (SA-AKI) in vitro and in vivo, and to clarify the role of ferroptosis in this protection. Human renal tubular epithelial cell (R...
RBM15B/IGF2BP2-m6A Mediated Upregulation of FNBP1 Promotes the Progression of Glioblastoma by Promoting Smad3-Mediated Glycolysis [0.03%]
RBM15B/IGF2BP2介导的FNBP1mRNA m6A修饰促进胶质母细胞瘤中Smad3依赖性糖酵解以此来促进肿瘤发展
Liang Zhang,Fei Li,Lingxue Zhang et al.
Liang Zhang et al.
Glioblastoma (GBM) is the most common and lethal primary intracranial tumor, and glycolysis has been reported to play a critical role in its progression. Formin-binding protein 1 (FNBP1) has been implicated in GBM progression; however, the ...
β-Elemene Suppresses Proliferation, Migration, and Stemness in Triple-Negative Breast Cancer by Inhibiting SIX-1 [0.03%]
β-艾里酚通过抑制SIX1抑制三阴性乳腺癌的增殖、迁移和干性
Jia Liu,Xudong Yan,Mingyan Wang et al.
Jia Liu et al.
Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited treatment options and poor prognosis. This study investigated the therapeutic potential of β-Elemene, a sesquiterpene from traditional Chinese medicine, against ...
Mechanism of Berberine Ameliorating Severe Pneumonia by Targeting PTGS2 Inhibition to Regulate C-Type Lectin Receptor Pathway, Mitochondrial Function and Cellular Focalization [0.03%]
小檗碱通过靶向PTGS2抑制改善重度肺炎的作用机制研究：C型凝集素受体信号通路、线粒体功能及细胞聚集角度分析
Kai Wang,Wei Zhao,Xiao-Hong Yin et al.
Kai Wang et al.
Severe pneumonia remains a major global health burden owing to its high morbidity and mortality, placing substantial strain on healthcare systems. Although berberine shows therapeutic potential against lung infections, its effects and mecha...
Multi-Target Rational Design and Synthesis of Some 2-Quinolinone Antitumor Candidates Downregulating the Expression of EGFR, VEGFR-2, and Telomerase With Apoptotic Potential [0.03%]
多靶向理性设计并合成一些下调EGFR、VEGFR-2和端粒酶表达的具有促凋亡潜力的抗肿瘤喹啉酮类候选药物
Eman A E El-Helw,Mai H A Mousa,Eman A Ghareeb et al.
Eman A E El-Helw et al.
The literature represented that the 2-quinolone moiety is present in diverse potent EGFR, VEGFR-2, and telomerase cellular downregulators. Accordingly, it was incorporated in new scaffolds (2, 3, 5, and 8-12), keeping in mind its attachment...
Cardiovascular Safety of VIAN-c4551, an Antiangiogenic Peptide Derived From Vasoinhibin [0.03%]
血管生成抑制素衍生的抗血管生成肽VIAN-c4551的心脏安全性研究
Miguel A García-González,Alejandro D Miguel-Martínez,Abimael González-Hernández et al.
Miguel A García-González et al.
Vasoinhibin is a potent antiangiogenic protein that blocks the activation of endothelial nitric oxide synthase (eNOS) in response to vascular endothelial growth factor, bradykinin, and acetylcholine (ACh). In this regard, VIAN-c4551, a new ...
Targeting mTOR Kinase for Cancer Treatment: A Comprehensive Review With Clinical Insights [0.03%]
针对癌症治疗的mTOR激酶靶向：具有临床洞察力的全面回顾
Md Takdir Hossain,Md Arafat Hossain
Md Takdir Hossain
Cancer remains a significant global health challenge, with increasing incidence and mortality rates worldwide. The mechanistic target of rapamycin (mTOR) pathway, a central regulator of cell growth, proliferation, metabolism, and survival, ...
Baicalin Promotes Recovery Following Intracerebral Hemorrhage by Inhibiting Ferroptosis in Brain Tissue Through Modulation of AKT/Nrf2/GPX4 Axis [0.03%]
刺五加皂苷通过调节AKT/Nrf2/GPX4轴抑制脑组织铁死亡促进脑出血后恢复
Zhenfei Yu,Xiaoling Qian,Weihua Wu et al.
Zhenfei Yu et al.
Intracerebral hemorrhage (ICH) is a serious acute cerebrovascular disease with a high death and disability rate. Baicalin plays a neuroprotective role in various diseases, but its regulatory mechanism on ICH remains unclear. In this study, ...