Multitargeted Anti-Inflammatory Agents: Novel Pyrazole and Pyrazolo[1,5-a]Pyrimidine Carbonic Anhydrase and COX-2 Inhibitors With Optimal In Vivo Efficacy and Low Toxicity
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In this study, three series of pyrazole and pyrazolo[1,5-a]pyrimidine derivatives 6a-f, 8a-f, and 10a-f were designed and synthesized in response to the global need to safe and potent anti-inflammatory agents. A rational design strategy was employed to synthes... ...
