Efficacy of a phenol derivative, isopropyl vanillate, as an anti-inflammatory agent: A new small molecule inhibitor of COX and neutrophil migration [0.03%]
苯酚衍生物异丙基香草酸作为抗炎剂的效果：一种新的环氧化酶和中性粒细胞迁移的小分子抑制剂
Kerolayne M Nogueira,Luan K M de Souza,Ana P de Oliveira et al.
Kerolayne M Nogueira et al.
Inflammation is the response of the body to noxious stimuli such as infections, trauma, or injury. Experimental studies have shown that vanillic acid has anti-inflammatory effects. The objective of this study was to investigate the anti-inf...
Identification of embelin, a 3-undecyl-1,4-benzoquinone from Embelia ribes as a multitargeted anti-Alzheimer agent [0.03%]
从_embelia ribes_鉴定出的针对多靶点抗阿尔茨海默病制剂embelin(3-十一烷基-1,4-苯醌)
Vijay K Nuthakki,Ankita Sharma,Ajay Kumar et al.
Vijay K Nuthakki et al.
Beta-secreatse (BACE-1) and cholinesterases are clinically validated targets of Alzheimer's disease (AD), for which natural products have provided immense contribution. The multifaceted nature of AD signifies the need of multitargeted agent...
Curcumin ameliorates experimental autoimmune encephalomyelitis in a C57BL/6 mouse model [0.03%]
姜黄素通过C57BL/6小鼠模型改善自身免疫性脑脊髓炎
Emran Esmaeilzadeh,Maryam Soleimani,Davood Zare-Abdollahi et al.
Emran Esmaeilzadeh et al.
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. Although the exact etiology of the disease is largely unknown, it is identified that cytokines may play an important role in the pathogenesis of MS. In ...
Berberine inhibits the interleukin-1 beta-induced inflammatory response via MAPK downregulation in rat articular chondrocytes [0.03%]
番红花红抑制MAPK下调介导的白细胞介素1β诱导的大鼠关节软骨细胞炎性反应
Xing Li,Peiheng He,Yu Hou et al.
Xing Li et al.
Osteoarthritis (OA) is one of the most chronic degenerative arthritic diseases, which gradually results in chondrocyte changes, articular cartilage degeneration, subchondral bone sclerosis, joint pain, swelling, and dysfunction. Berberine (...
Synthesis and docking studies of N-(5-(alkylthio)-1,3,4-oxadiazol-2-yl)methyl)benzamide analogues as potential alkaline phosphatase inhibitors [0.03%]
N-(5-(烷基硫)-1,3,4-噁二唑-2-基)甲基)苯胺类似物作为潜在碱性磷酸酶抑制剂的合成与对接研究
Zafar Iqbal,Ambreen Iqbal,Zaman Ashraf et al.
Zafar Iqbal et al.
A series of N-(5-(alkylthio)-1,3,4-oxadiazol-2-yl)methyl)benzamides 6a-i were synthesized as alkaline phosphatase inhibitors. The intermediate 5-substituted 1,3,4-oxadiazole-2-thione 4 was synthesized starting with hippuric acid. Hippuric a...
Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase [0.03%]
1H-吡咯并〔2，3-B〕吡啶衍生物进一步结构修饰作为人中性粒细胞弹性蛋白酶抑制剂的研究
Maria P Giovannoni,Niccolò Cantini,Letizia Crocetti et al.
Maria P Giovannoni et al.
Human neutrophil elastase (HNE) is a potent protease that plays an important physiological role in many processes and is considered to be a multifunctional enzyme. HNE is also involved in a variety of pathologies affecting the respiratory s...
Synthesis, in vivo anticonvulsant testing, and molecular modeling studies of new nafimidone derivatives [0.03%]
新的纳非咪酮衍生物的合成、体内抗惊厥试验及分子模拟研究
Mustafa F Acar,Suat Sari,Sevim Dalkara
Mustafa F Acar
An estimated 50 million people suffer epilepsy worldwide and 30% of the cases do not respond to current antiepileptic drugs (AEDs). Here, we report synthesis and anticonvulsant screening of new derivatives of nafimidone, a well-known member...
Anti-inflammatory effects of Vicenin-2 on dextran sulfate sodium-induced colitis in mice [0.03%]
木犀草素-2抑制葡聚糖硫酸钠诱导的小鼠结肠炎的作用及其机制研究
Yuti Yin,Lei Ye,Zhongbao Niu et al.
Yuti Yin et al.
The objective of the present work was to evaluate the anti-inflammatory effects of Vicenin-2 on dextran sulfate sodium (DSS)-induced colitis model. Colitis was induced in C57BL/6J mice by administration of 2% DSS in drinking water for 7 day...
Synthesis, characterization, molecular docking evaluation, antidepressant, and anti-Alzheimer effects of dibenzylidene ketone derivatives [0.03%]
茋茋茋茋茋茋茋茋茋茋茋二苯并茋茋酮衍生物的合成、表征、分子对接评估及抗抑郁和抗阿尔茨海默氏病效应
Muhammad Adnan Bashir,Arif-Ullah Khan,Haroon Badshah et al.
Muhammad Adnan Bashir et al.
Novel bioactive compounds as synthetic analogs of the potent herbal medicines can be optimized as potential drug candidates for various neurologic disorders. This study was performed to investigate the newly synthesized dibenzylidene ketone...
Pharmacodynamic interaction of 3α-hydroxymasticadienonic acid and diligustilide against indomethacin-induced gastric damage in rats [0.03%]
姜黄酸内酯与细柱香草甲素对吲哚美辛致大鼠胃损伤的药动学相互作用研究
Elizabeth A Pineda-Peña,Dulce G Meza-Pérez,Aracely E Chávez-Piña et al.
Elizabeth A Pineda-Peña et al.
The aims of the study were to evaluate the pharmacodynamic interaction between 3α-hydroxymasticadienonic acid and diligustilide (DLG), isolated from the plants Amphiptherygium adstringens and Ligusticum porteri, respectively, using the ind...