Differential regulation of intestinal and hepatic CYP3A by 1α,25-dihydroxyvitamin D3 : Effects on in vivo oral absorption and disposition of buspirone in rats [0.03%]
1α,25-二羟基维生素D3对大鼠肠道和肝脏CYP3A的差异调节：对体内_buspirone_口服吸收及处置的影响
Han-Joo Maeng,Trang Nguyen Kieu Doan,In-Soo Yoon
Han-Joo Maeng
1α,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). It was previously reported that intestinal cytochrome P450 3A (CY...
Comparative Study
Drug development research. 2019 May;80(3):333-342. DOI:10.1002/ddr.21505 2019
Evaluation of selected commercial pharmacotherapeutic drugs as potential pancreatic lipase inhibitors and antiproliferative compounds [0.03%]
评估几种商用药物作为潜在胰腺脂肪酶抑制剂和抗增殖化合物的效果
Noor Mamdooh,Violet Kasabri,Yusuf Al-Hiari et al.
Noor Mamdooh et al.
In this study, 15 commercial acidic drugs have been evaluated for pancreatic lipase (PL) inhibitory activity using an in vitro spectrophotometric method. The acidity was the basis of selection, since most PL inhibitors exhibit acidic groups...
Spontaneous mutations conferring antibiotic resistance to antitubercular drugs at a range of concentrations in Mycobacterium smegmatis [0.03%]
多重浓度抗结核药物诱导星形芽孢杆菌的自发耐药突变体筛选及测序分析
Iveren Winifred Nyinoh
Iveren Winifred Nyinoh
Mycobacteria populations can undergo mutations in their DNA sequence during replication, which if not repaired would be transferred to future generations. Earlier studies have tackled the estimation of mutation rate in mycobacteria at fixed...
Hongtao Xiao,Tingting Shi,Lizhu Han et al.
Hongtao Xiao et al.
Primary dysmenorrhea affects the quality of life in young women, particularly school and work performance. This study investigated the mechanisms of penehyclidine hydrochloride (PHC) efficacy on a rat model of primary dysmenorrhea. The mode...
Design and synthesis of simplified speciophylline analogues and β-carbolines as active molecules against Plasmodium falciparum [0.03%]
简化的speciophylline类似物和β-咔啉类化合物作为抗疟活性分子的设计与合成
David Pierrot,Véronique Sinou,Sok-Siya Bun et al.
David Pierrot et al.
A structure-activity relationship study of active molecules against chloroquine-resistant Plasmodium falciparum K1 strain is reported. Structurally simplified analogues of antiplasmodial active alkaloids presented similar levels of activity...
Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma [0.03%]
丁香酸对哮喘小鼠模型抗氧化生物标志物及相关的炎症因子的影响研究
Yinfang Li,Li Zhang,Xiaohua Wang et al.
Yinfang Li et al.
Asthma is termed as the induction of chronic inflammation in the airway lumen of lungs due to accumulation of inflammatory cells which affects normal breathing process. Prolonged accumulation of inflammatory cells leads to oxidative stress ...
Synthesis, anticonvulsant screening, and molecular modeling studies of new arylalkylimidazole oxime ether derivatives [0.03%]
新型芳基烯丙基咪唑肟醚衍生物的合成、抗惊厥筛选及分子模拟研究
Zeynep Özdemir,Suat Sari,Arzu Karakurt et al.
Zeynep Özdemir et al.
In this study, 15 new oxime ether derivatives were synthesized and their anticonvulsant activities were screened in vivo. The compounds were synthesized by the reaction of various alkyl halides with 1-(2-naphthyl)-2-(1H-imidazol-1-yl)ethano...
Gautam Singhvi,Prachi Manchanda,Neha Hans et al.
Gautam Singhvi et al.
Microsponges are the spherical particles ranging from 5 to 300 μm in size. These are further made up of clusters of smaller spheres. They are designed for delivering the drug efficiently at a comparatively lesser dose and enhancing the sta...
Drug sales confirm clinical advantage of multi-target inhibition of drug escapes by anticancer kinase inhibitors [0.03%]
药物销售证实了抗癌激酶抑制剂多靶点抑制的临床优势及克服药物逃逸能力
Shangying Chen,Sheng Yong Yang,Zhe Chen et al.
Shangying Chen et al.
The clinical advantage of co-targeting cancer drug escape has been indicated by the percentage of these co-targeting drugs among all multi-target drugs in clinics and clinical trials. This clinical advantage needs to be further interrogated...
Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol-bound punicic acid for increased antihepatotoxic activity [0.03%]
负载三酰甘油结合花生四烯酸的纳米脂质体的制备、优化及药动学研究以增强其抗肝毒性作用
Michael Adu-Frimpong,Caleb Kesse Firempong,Emmanuel Omari-Siaw et al.
Michael Adu-Frimpong et al.
Punicic acid of pomegranate oil (PAP) has gained heightened interest due to several health benefits, such as anticarcinogenic, antidiabetic, and antiatherosclerotic properties. However, these bioactivities have been hampered by chemical ins...