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Synthesis, in vivo anticonvulsant testing, and molecular modeling studies of new nafimidone derivatives

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An estimated 50 million people suffer epilepsy worldwide and 30% of the cases do not respond to current antiepileptic drugs (AEDs). Here, we report synthesis and anticonvulsant screening of new derivatives of nafimidone, a well-known member of (arylakyl)azole ... ...