Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors [0.03%]
神经元生成的凝血酶通过蛋白酶激活受体诱导具有保护性的星形胶质细胞反应
Padmesh S Rajput,Jessica Lamb,Shweta Kothari et al.
Padmesh S Rajput et al.
Astrocytes protect neurons during cerebral injury through several postulated mechanisms. Recent therapeutic attention has focused on enhancing or augmenting the neuroprotective actions of astrocytes but in some instances astrocytes can assu...
Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane [0.03%]
一氧化氮可以上调小胶质细胞的吞噬作用并增加瞬时受体电位香草亚型通道2在细胞膜上的表达
Matthew J E Maksoud,Vasiliki Tellios,Dong An et al.
Matthew J E Maksoud et al.
Microglia phagocytosis is critical for central nervous system development, and dysregulation of phagocytosis may contribute to a variety of neurological disorders. During initial stages of phagocytosis, microglia display increased nitric ox...
Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration [0.03%]
炎症引起的哺乳动物雷帕霉素靶蛋白信号通路对视网膜再生至关重要
Zhiqiang Zhang,Haitao Hou,Shuguang Yu et al.
Zhiqiang Zhang et al.
Upon retina injury, Müller glia in the zebrafish retina respond by generating multipotent progenitors to repair the retina. However, the complete mechanisms underlying retina regeneration remain elusive. Here we report inflammation-induced...
Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped? [0.03%]
脊髓损伤后时间点的髓鞘状态和少突胶质细胞谱系细胞：我们已知什么？仍需了解什么？
Nicole Pukos,Matthew T Goodus,Fatma R Sahinkaya et al.
Nicole Pukos et al.
Spinal cord injury (SCI) affects over 17,000 individuals in the United States per year, resulting in sudden motor, sensory and autonomic impairments below the level of injury. These deficits may be due at least in part to the loss of oligod...
Inhibitory milieu at the multiple sclerosis lesion site and the challenges for remyelination [0.03%]
多发性硬化症病灶处的抑制微环境与髓鞘再生面临的挑战
Dylan A Galloway,Elizabeth Gowing,Solmaz Setayeshgar et al.
Dylan A Galloway et al.
Regeneration of myelin, following injury, can occur within the central nervous system to reinstate proper axonal conductance and provide trophic support. Failure to do so renders the axons vulnerable, leading to eventual degeneration, and n...
Reactive microglia and astrocytes in neonatal intraventricular hemorrhage model are blocked by mesenchymal stem cells [0.03%]
间充质干细胞可阻断新生儿脑室内出血模型中的小胶质细胞和星形胶质细胞活化反应式炎症表型
Seojeong Kim,Young Eun Kim,Sujeong Hong et al.
Seojeong Kim et al.
Severe intraventricular hemorrhage (IVH) in premature infants triggers reactive gliosis, causing acute neuronal death and glial scar formation. Transplantation of mesenchymal stem cells (MSCs) has often showed improved CNS recovery in an IV...
The fate and function of oligodendrocyte progenitor cells after traumatic spinal cord injury [0.03%]
脊髓损伤后少突前体细胞的命运和功能
Greg J Duncan,Sohrab B Manesh,Brett J Hilton et al.
Greg J Duncan et al.
Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population of progenitor cells in the adult central nervous system, which allows these cells to rapidly respond to damage. Oligodendrocytes and myelin are lost...
Piezo1 regulates calcium oscillations and cytokine release from astrocytes [0.03%]
Piezo1调节星形胶质细胞的钙振荡和细胞因子释放
María Velasco-Estevez,Sara O Rolle,Myrthe Mampay et al.
María Velasco-Estevez et al.
Astrocytes are important for information processing in the brain and they achieve this by fine-tuning neuronal communication via continuous uptake and release of biochemical modulators of neurotransmission and synaptic plasticity. Often ove...
Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes [0.03%]
G蛋白偶联受体30通过调节星形胶质细胞的自噬来保护神经元
Xin-Shang Wang,Jiao Yue,Li-Ning Hu et al.
Xin-Shang Wang et al.
Ischemic stroke leads to neuronal damage induced by excitotoxicity, inflammation, and oxidative stress. Astrocytes play diverse roles in stroke and ischemia-induced inflammation, and autophagy is critical for maintaining astrocytic function...
Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists [0.03%]
腺苷A2A受体拮抗剂通过胶质细胞增敏 cannabinoid信号传导
Rafael Franco,Irene Reyes-Resina,David Aguinaga et al.
Rafael Franco et al.
Neuroprotective M2-skewed microglia appear as promising to alter the course of neurodegenerative diseases and G protein-coupled receptors (GPCRs) are potential targets to achieve such microglial polarization. A common feature of adenosine A...