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Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists

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Neuroprotective M2-skewed microglia appear as promising to alter the course of neurodegenerative diseases and G protein-coupled receptors (GPCRs) are potential targets to achieve such microglial polarization. A common feature of adenosine A2A (A2A R) and canna... ...