Specific Deletion of Interleukin-1 Beta in Microglia Improves Acute Outcome and Modulates Neurogenesis After Ischemic Stroke [0.03%]
特异性删除小胶质细胞中的白介素-1β可改善缺血性卒中后的急性预后并调节神经发生
Alba Grayston,Margarida Baptista,Kelly Wemyss et al.
Alba Grayston et al.
Interleukin-1 (IL-1) signaling is a major driver of post-ischemic neuroinflammation, yet the cell- and isoform-specific roles of the two major IL-1 receptor type 1 agonists, IL-1α and IL-1β, remain incompletely defined in the context of s...
Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System [0.03%]
星形胶质细胞机械生物学：中枢神经系统生物力学与生化信号转导之间的联系
Ana N Strat,Alima Ahmed,Mariano Viapiano et al.
Ana N Strat et al.
Astrocytes are the most abundant glial cells within the central nervous system. They are highly specialized mechanosensors able to detect the kinetics and magnitude of external biomechanical stimuli (i.e., matrix substrate stiffness and she...
Sharlen Moore,Swati Subramanian,Martin Meschkat et al.
Sharlen Moore et al.
Lateralization of brain functions, such as handedness, is thought to enhance cortical efficacy by reducing redundancy and speeding up decision-making. The corpus callosum (CC), one of the brain's largest myelinated tracts, is critical for i...
Dissociation Between Hemodynamic and Metabolic Responses to Chemogenetic Modulation of Astrocytes in Mouse Visual Cortex [0.03%]
化学遗传学调控小鼠视觉皮层 astrocytes 激活的血流和代谢反应脱偶联现象研究
Mickaël Pereira,Benjamin Vidal,Marco Valdebenito et al.
Mickaël Pereira et al.
Astrocytes play a critical role in brain homeostasis and energetics, yet their exact contribution to neurovascular and neurometabolic coupling is not fully elucidated. In particular, how astrocytic activity participates in shaping the funct...
Harnessing Microglial Repopulation: From Inflammatory Drivers to Therapeutic Allies in CNS Diseases [0.03%]
利用小胶质细胞再植的力量：从炎症驱动因素到中枢神经系统疾病治疗的盟友
Guanyu Li,Hong Liu,Zhida Lan et al.
Guanyu Li et al.
Microglia, the tissue-resident macrophages of the central nervous system (CNS), execute essential functions in neural development, homeostasis, and repair. However, their persistent or dysregulated activation is a hallmark of diverse neurol...
Walnut-Derived Extracellular Vesicles Orchestrate a Pre-Regenerative Niche via c-Myc Mediated Metabolic Reprogramming [0.03%]
核桃来源的细胞外囊泡通过c-Myc介导的代谢重编程调控再生微环境
Junyang Gao,Genzhong Xu,Nianci Huo et al.
Junyang Gao et al.
Peripheral nerve injury (PNI) remains a major regenerative challenge, in part because the post-injury microenvironment can disrupt Schwann cell (SCs) homeostasis. Walnuts (Juglans regia) have long been used in ethnomedicine for perceived ne...
Microglial Pruning of Excitatory Synapses in the Hippocampus Is Complement C3-Independent in Physiological and Neuroinflammatory States [0.03%]
小胶质细胞对海马区兴奋性突触的修剪作用在生理和神经炎症状态下都不依赖补体C3分子
Eric W Salter,Ashish Kadia,Lijia Zhang et al.
Eric W Salter et al.
A key feature of brain development is the refinement of exuberant synapses, known as synapse pruning. This phenomenon is executed by microglia, the resident immune cells of the brain. Evidence that microglia prune retinal inputs via activat...
Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro-Inflammatory Responses via Modulation of JNK and NFkB Signaling [0.03%]
通过调节JNK和NF-kB信号降低小胶质细胞促炎反应可能使SH3RF3减少对阿尔茨海默病具有保护作用
Ronak Patel,Rong Cheng,Christopher L Cardona et al.
Ronak Patel et al.
Understanding how high-risk individuals are protected from Alzheimer's disease (AD) may illuminate potential therapeutic targets. We identified protective genetic variants in SH3RF3/POSH2 that delayed the onset of AD among individuals carry...
A Cross-Disease Microglial Transcriptional Program Characterizes Neurodegeneration and Highlights SPP1 as a Biomarker [0.03%]
跨疾病的小胶质细胞转录程序表征神经退行性病变并突出SPP1作为生物标志物
Alessandro Palma,Roberta Stefanelli,Francesco Trenta et al.
Alessandro Palma et al.
Microglial cells are key players in maintaining brain homeostasis and responding to pathological conditions. Their multifaceted roles in health and disease have garnered significant attention in the context of neurodegeneration. In recent y...
Targeted Inhibition of MEGF10-Mediated Astrogliosis Reduces Glial Scar Formation and Promotes Neurofunction Recovery in Mice After Stroke [0.03%]
靶向抑制MEGF10介导的星形胶质细胞反应减少脑卒中后小鼠胶质瘢痕形成和促进神经功能恢复
Jingjing Xu,Tongtong Xu,Lin Gan et al.
Jingjing Xu et al.
The formation of glial scar at the chronic stage of neurological disease is mainly attributed to the activation and proliferation of astrocytes, termed astrogliosis. It is documented that astrogliosis-induced glial scar formation following ...