A Microglia-Astrocyte Signaling Axis Regulates Astrocyte Piezo1 Expression and Inflammatory Responses [0.03%]
小胶质细胞-星形胶质细胞信号轴调控星形胶质细胞Piezo1表达及炎症反应
Yanyang Bai,Hyun B Choi,Stefan Wendt et al.
Yanyang Bai et al.
Structural tissue alterations in numerous brain disorders can initiate mechanosensory signaling pathways and influence neuropathology. Astrocytes are highly mechanosensitive cells that play essential roles in maintaining brain homeostasis; ...
Cdk7 Regulates Myelin Sheath Morphology and Lipid Homeostasis in Schwann Cells [0.03%]
Cdk7调节施万细胞髓鞘形态和脂质稳态
Nathalie Schumacher,Alexandra Pieltain,Pierre Tocquin et al.
Nathalie Schumacher et al.
Schwann cells (SC) are responsible for myelination in the peripheral nervous system (PNS). Myelin allows saltatory transmission of action potentials along axons and functionally relies on its unique constitution. We previously reported that...
Quantifying Heteromer Partitioning Reveals Inflammation-Dependent Redistribution of Microglial Adenosine A2A and Cannabinoid CB2 Receptors [0.03%]
量化异聚体分区揭示了炎症依赖性的小胶质细胞腺苷A2A和 cannabinoid CB2受体的重新分布
Rafael Franco,Jaume Lillo,Christian Griñán-Ferré et al.
Rafael Franco et al.
G protein-coupled receptor (GPCR) heteromerization represents a key organizational mechanism in cell signaling, but it remains difficult to determine, in native cells, how receptor-associated signals are distributed between non-interacting ...
Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability [0.03%]
卫星胶质细胞合成并释放GABA以激活额外突触GABAA受体来调节DRG神经元兴奋性
Natalie Jiménez-Barrios,Ricardo González-Ramírez,Francisco Javier Paz-Bermúdez et al.
Natalie Jiménez-Barrios et al.
Sensory neurons express extrasynaptic GABAA receptors in their soma and axon, tonically activated by ambient GABA, modulating their excitability. However, the specific glial or neuronal origin of endogenous GABA that modulates this excitabi...
Deletion of Astrocytic TNFR1 Attenuates Hyperexcitability and Initiation of Epileptogenesis [0.03%]
星形胶质细胞TNFR1缺失可减轻神经元过度兴奋和癫痫发作起始
Lukas Henning,Ioannis Zalachoras,Giovanni Carriero et al.
Lukas Henning et al.
Temporal lobe epilepsy (TLE), the most common form of adult focal epilepsy, is highly resistant to current medical therapy. Cytokine signaling, including via tumor necrosis factor-alpha (TNFα), has been implicated not only as an accompanyi...
VPS35 Regulates Microglial Lipid Droplet Accumulation in Parkinson's Disease via Rab7 [0.03%]
VPS35通过Rab7调节帕金森病中的微胶质细胞脂滴累积
Yue Liang,Tong Chang,Leping Yan et al.
Yue Liang et al.
Microglial dysfunction and aberrant lipid metabolism are emerging as key contributors to Parkinson's disease (PD) pathogenesis. However, the specific role and regulation of lipid droplets (LDs) within microglia remain poorly defined. In thi...
A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory [0.03%]
TREK-1/AQP4/TRPA1/ BDNF 信号轴与星形胶质细胞体积瞬变、突触可塑性和空间记忆有关
Victor James Drew,Junsung Woo,Jung Moo Lee et al.
Victor James Drew et al.
Astrocytes, known for their support roles, are emerging as active participants in synaptic plasticity and cognitive functions. Astrocytes actively regulate synaptic plasticity and memory through dynamic volume transients. Our previous resea...
Navigating Human Astrocyte Differentiation: Direct and Rapid One-Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development [0.03%]
人类星形胶质细胞分化的导航：诱导多能干细胞直接一步分化为功能性星形胶质细胞支持神经网络发育
Imke M E Schuurmans,Annika Mordelt,Marta Guevara-Ferrer et al.
Imke M E Schuurmans et al.
Astrocytes play a pivotal role in neuronal network development. Despite the well-known role of astrocytes in the pathophysiology of neurologic disorders, the utilization of induced pluripotent stem cell (iPSC)-derived astrocytes in neuronal...
Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model [0.03%]
C1q基因敲除减少突触吞噬作用并部分缓解阿尔茨海默病小鼠模型中的认知障碍
Tiffany J Petrisko,Shu-Hui Chu,Angela Gomez-Arboledas et al.
Tiffany J Petrisko et al.
C1q is a multifunctional protein, including its role as the initiating protein of the classical complement cascade. While classical pathway activation is involved in synaptic pruning during nervous system development, it also contributes to...
Genetic Deletion of Adenosine A2A Receptors Attenuates Aged-Related Alterations of Glial Cells Morphology and of Inflammasome in the Hippocampus and Prefrontal Cortex of Mice [0.03%]
遗传敲除腺苷A2A受体减轻小鼠海马和前额叶皮质中与年龄相关的胶质细胞形态和炎性小体的改变
Cátia R Lopes,Samira G Ferreira,Rodrigo A Cunha et al.
Cátia R Lopes et al.
Although brain disorders are the major burden of disease in Western countries and their incidence increases sharply with aging, the biological basis of brain aging is still poorly explored. Glial cells, namely microglia and astrocytes, main...