In Transected Nerves, Distal Repair Schwann Cells at the Injury Site Direct and Accelerate Axonal Regrowth [0.03%]
施万细胞在受损部位直接促进和加速神经离断再接处轴突生长
Daniel E Lysko,Annika R Johnson,William S Talbot
Daniel E Lysko
In vertebrate peripheral nerves, damaged axons can regrow after injury, but the outcomes of regeneration are variable and often incomplete. Schwann cells in injured nerves are important for repair, but their actions at different positions a...
Gq Signaling in Microglia Triggers Interferon Responses and Improves Outcome After Ischemic Stroke [0.03%]
小胶质细胞中的Gq信号触发干扰素反应并改善缺血性卒中后的预后
Lynn Bitar,Marie-Luise Brehme,Charlotte Oldenburg et al.
Lynn Bitar et al.
Post-stroke recovery remains limited despite advances in acute reperfusion therapies, underscoring the need to better understand underlying mechanisms that shape repair. Microglia, the resident immune cells of the central nervous system, or...
Samira Monshietehadi,Angel J Garcia,Benjamin E Smith et al.
Samira Monshietehadi et al.
Coordinated signaling among neurons, glia, and the vasculature is essential for nervous system development. In the developing retina, spontaneous cholinergic retinal waves are the primary source of neural activity during the early maturatio...
Predicting Relevant Microglia-Associated Cell-Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1 [0.03%]
预测阿尔茨海默病中相关的小胶质细胞关联的细胞通讯通路：SPP1的作用
Janssen M Kotah,Marina Trombetta Lima,Esmée C Dragt et al.
Janssen M Kotah et al.
Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease progression. We previously identified distinct microglial signatures that were enriched in AD donors and a...
A Microglia-Astrocyte Signaling Axis Regulates Astrocyte Piezo1 Expression and Inflammatory Responses [0.03%]
小胶质细胞-星形胶质细胞信号轴调控星形胶质细胞Piezo1表达及炎症反应
Yanyang Bai,Hyun B Choi,Stefan Wendt et al.
Yanyang Bai et al.
Structural tissue alterations in numerous brain disorders can initiate mechanosensory signaling pathways and influence neuropathology. Astrocytes are highly mechanosensitive cells that play essential roles in maintaining brain homeostasis; ...
Cdk7 Regulates Myelin Sheath Morphology and Lipid Homeostasis in Schwann Cells [0.03%]
Cdk7调节施万细胞髓鞘形态和脂质稳态
Nathalie Schumacher,Alexandra Pieltain,Pierre Tocquin et al.
Nathalie Schumacher et al.
Schwann cells (SC) are responsible for myelination in the peripheral nervous system (PNS). Myelin allows saltatory transmission of action potentials along axons and functionally relies on its unique constitution. We previously reported that...
Quantifying Heteromer Partitioning Reveals Inflammation-Dependent Redistribution of Microglial Adenosine A2A and Cannabinoid CB2 Receptors [0.03%]
量化异聚体分区揭示了炎症依赖性的小胶质细胞腺苷A2A和 cannabinoid CB2受体的重新分布
Rafael Franco,Jaume Lillo,Christian Griñán-Ferré et al.
Rafael Franco et al.
G protein-coupled receptor (GPCR) heteromerization represents a key organizational mechanism in cell signaling, but it remains difficult to determine, in native cells, how receptor-associated signals are distributed between non-interacting ...
Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability [0.03%]
卫星胶质细胞合成并释放GABA以激活额外突触GABAA受体来调节DRG神经元兴奋性
Natalie Jiménez-Barrios,Ricardo González-Ramírez,Francisco Javier Paz-Bermúdez et al.
Natalie Jiménez-Barrios et al.
Sensory neurons express extrasynaptic GABAA receptors in their soma and axon, tonically activated by ambient GABA, modulating their excitability. However, the specific glial or neuronal origin of endogenous GABA that modulates this excitabi...
Deletion of Astrocytic TNFR1 Attenuates Hyperexcitability and Initiation of Epileptogenesis [0.03%]
星形胶质细胞TNFR1缺失可减轻神经元过度兴奋和癫痫发作起始
Lukas Henning,Ioannis Zalachoras,Giovanni Carriero et al.
Lukas Henning et al.
Temporal lobe epilepsy (TLE), the most common form of adult focal epilepsy, is highly resistant to current medical therapy. Cytokine signaling, including via tumor necrosis factor-alpha (TNFα), has been implicated not only as an accompanyi...
VPS35 Regulates Microglial Lipid Droplet Accumulation in Parkinson's Disease via Rab7 [0.03%]
VPS35通过Rab7调节帕金森病中的微胶质细胞脂滴累积
Yue Liang,Tong Chang,Leping Yan et al.
Yue Liang et al.
Microglial dysfunction and aberrant lipid metabolism are emerging as key contributors to Parkinson's disease (PD) pathogenesis. However, the specific role and regulation of lipid droplets (LDs) within microglia remain poorly defined. In thi...