Visualization and Cluster Analysis of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer: Research Trends and Future Directions [0.03%]
colorectal cancer中PPAR的可视化与聚类分析：研究趋势和未来方向
Bo Dong,Bin Zhou,Hong Zhang et al.
Bo Dong et al.
Objective: Peroxisome proliferator-activated receptors (PPARs) are essential regulators in the development and progression of colorectal cancer (CRC). However, a comprehensive bibliometric analysis of PPAR-related CRC res...
A Novel MAP3K7 Variant Causing Loss of Function Identified in a Family With Cardiospondylocarpofacial Syndrome: Functional Validation and Molecular Insights [0.03%]
一种新的MAP3K7变异体导致功能丧失：在卡迪奥-脊柱-掌趾-面部综合征家系中鉴定及功能验证和分子机制探究
Ting Zhu,Jiamin Shi,Jia Li et al.
Ting Zhu et al.
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as transforming growth factor-β-activated kinase 1 (TAK1), is a widely expressed kinase that plays a crucial role in various cellular processes variants in the MAP3K7 ge...
Transcriptomic Analysis Reveals the Role of TRIM26 in Hepatocellular Carcinoma and Its Association With the Wnt/ β-catenin Signaling Pathway [0.03%]
转录组分析揭示了TRIM26在肝细胞癌中的作用及其与Wnt/β-catenin信号通路的关联
Conghua Song,Zijun Hou,Huifeng Wu et al.
Conghua Song et al.
Background: Hepatocellular carcinoma (HCC) shows high incidence and mortality worldwide. TRIM26, an E3 ubiquitin ligase within the TRIM family, exerts regulatory functions in various tumors. This study analyzed the expres...
Combined Nivolumab and Ipilimumab Therapy Promotes Immune-Mediated Cardiomyocyte Apoptosis Through TLR4-Myd88-NF- Κ b-Driven Activation of the NLRP3 Inflammasome [0.03%]
纳武单抗联合伊匹单抗治疗通过TLR4-Myd88-NF-Κb激活NLRP3炎性小体诱导心肌细胞免疫介导的凋亡
Mengjiao Gao,Xinya Liu,Li Wu et al.
Mengjiao Gao et al.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but are associated with serious immune-related cardiac toxicities. In this study, AC16 human cardiomyocytes were exposed to nivolumab alone or in combination with ipil...
Single-Cell Sequencing and Mendelian Randomization Reveal T Cell Nuclear Factor Genes in Hepatocellular Carcinoma Progression [0.03%]
单细胞测序和孟德尔随机化揭示肝癌进展中的一种T细胞核因子基因
Yunfei Chen,Xiting Yang,Lintao Zhong et al.
Yunfei Chen et al.
This study integrates single-cell RNA sequencing with Mendelian randomization to elucidate the role of nuclear factor of activated T cells (NFAT)-related genes in the progression of hepatocellular carcinoma (HCC). The GSE162616 dataset was ...
Prognostic Stratification and Subtyping of Glioblastoma Using Transient Receptor Potential Channels [0.03%]
基于瞬时受体电位通道的胶质母细胞瘤预后分层及分子亚型分析
Runfeng Sun,Long Zhu,Zhichao Lu et al.
Runfeng Sun et al.
Background: Transient receptor potential (TRP) channels regulate Ca2+ homeostasis and tumor malignant phenotypes, whereas their prognostic relevance and therapeutic implications in glioblastoma (GBM) remain poorly charact...
HSPB6: A Potential Prognostic Biomarker, Inhibiting the Epithelial-Mesenchymal Transition (EMT) Process Through the PI3K/Akt Signaling Pathway Based on the Machine Learning and Experimental Validation [0.03%]
基于机器学习和实验验证的HSPB6：一种潜在的预后生物标志物，可通过PI3K / Akt信号通路抑制上皮-间质转化（EMT）过程
Jian-She Wang,Yi-Fan Qiu,Lu Zhang et al.
Jian-She Wang et al.
Bladder cancer (BC) is a prevalent malignant tumor worldwide, posing a significant public health burden and challenge to human society. Current therapeutic modalities for BC include surgical treatment, radiotherapy, chemotherapy, targeted t...
Multiomics Analysis Identifies Chromosomal Instability-Associated Immune-Related Signatures in Hepatocellular Carcinoma by Integrating Weighted Gene Coexpression Network Analysis (WGCNA) and Machine Learning [0.03%]
整合加权基因共表达网络分析（WGCNA）和机器学习，通过多组学分析在肝细胞癌中鉴定染色体不稳定相关的免疫特征
Zehao Li,Boqiang Zhong,Qian Zhang et al.
Zehao Li et al.
Background: Hepatocellular carcinoma (HCC) is a top cause of cancer-related death globally, with late diagnosis due to nonspecific early symptoms. Current single-factor prognostic models cannot reflect tumor heterogeneity...
Multiomics Biomarkers for Differential Diagnosis of Pleural Effusion: Integration of Proteomic Markers and Single-Cell Transcriptomics [0.03%]
用于胸腔积液鉴别诊断的多组学生物标志物：蛋白质组标志物与单细胞转录组学的整合
Zhengyou Zhang,Shaowei Zhan,Ying Tang et al.
Zhengyou Zhang et al.
Background: Differential diagnosis of pleural effusion remains challenging despite medical thoracoscopy (MT). We investigated whether integrating proteomic biomarkers with single-cell transcriptomics and genomic mutation ...
Delving Into the Depths of AGTR2: In Silico Identification of Deleterious Nonsynonymous SNPs Associated With Cardiovascular Diseases [0.03%]
深入探究AGTR2：与心血管疾病相关有害非同义SNP的分子识别
Muhammad Waleed Iqbal,Muhammad Shahab,Xinxiao Sun et al.
Muhammad Waleed Iqbal et al.
Background and aim: Nonsynonymous single nucleotide polymorphisms (nsSNPs) in angiotensin Type II receptor (AGTR2) have been identified as a potential cause of cardiovascular illness in humans. Identifying structurally an...