Single-Cell Sequencing and Mendelian Randomization Reveal T Cell Nuclear Factor Genes in Hepatocellular Carcinoma Progression [0.03%]
Yunfei Chen,Xiting Yang,Lintao Zhong et al.
Yunfei Chen et al.
This study integrates single-cell RNA sequencing with Mendelian randomization to elucidate the role of nuclear factor of activated T cells (NFAT)-related genes in the progression of hepatocellular carcinoma (HCC). The GSE162616 dataset was ...
Prognostic Stratification and Subtyping of Glioblastoma Using Transient Receptor Potential Channels [0.03%]
Runfeng Sun,Long Zhu,Zhichao Lu et al.
Runfeng Sun et al.
Background: Transient receptor potential (TRP) channels regulate Ca2+ homeostasis and tumor malignant phenotypes, whereas their prognostic relevance and therapeutic implications in glioblastoma (GBM) remain poorly charact...
HSPB6: A Potential Prognostic Biomarker, Inhibiting the Epithelial-Mesenchymal Transition (EMT) Process Through the PI3K/Akt Signaling Pathway Based on the Machine Learning and Experimental Validation [0.03%]
Jian-She Wang,Yi-Fan Qiu,Lu Zhang et al.
Jian-She Wang et al.
Bladder cancer (BC) is a prevalent malignant tumor worldwide, posing a significant public health burden and challenge to human society. Current therapeutic modalities for BC include surgical treatment, radiotherapy, chemotherapy, targeted t...
Multiomics Analysis Identifies Chromosomal Instability-Associated Immune-Related Signatures in Hepatocellular Carcinoma by Integrating Weighted Gene Coexpression Network Analysis (WGCNA) and Machine Learning [0.03%]
Zehao Li,Boqiang Zhong,Qian Zhang et al.
Zehao Li et al.
Background: Hepatocellular carcinoma (HCC) is a top cause of cancer-related death globally, with late diagnosis due to nonspecific early symptoms. Current single-factor prognostic models cannot reflect tumor heterogeneity...
Multiomics Biomarkers for Differential Diagnosis of Pleural Effusion: Integration of Proteomic Markers and Single-Cell Transcriptomics [0.03%]
Zhengyou Zhang,Shaowei Zhan,Ying Tang et al.
Zhengyou Zhang et al.
Background: Differential diagnosis of pleural effusion remains challenging despite medical thoracoscopy (MT). We investigated whether integrating proteomic biomarkers with single-cell transcriptomics and genomic mutation ...
Delving Into the Depths of AGTR2: In Silico Identification of Deleterious Nonsynonymous SNPs Associated With Cardiovascular Diseases [0.03%]
Muhammad Waleed Iqbal,Muhammad Shahab,Xinxiao Sun et al.
Muhammad Waleed Iqbal et al.
Background and aim: Nonsynonymous single nucleotide polymorphisms (nsSNPs) in angiotensin Type II receptor (AGTR2) have been identified as a potential cause of cardiovascular illness in humans. Identifying structurally an...
STIM1 as an Early Predictive Biomarker for Acute Respiratory Distress Syndrome (ARDS) and Its Potential Mechanisms [0.03%]
Shuping Deng,Qi Wu,Dan Zhou et al.
Shuping Deng et al.
Acute respiratory distress syndrome (ARDS) mainly results in severe respiratory failure and significant morbidity. This study decisively investigated the effectiveness and clinical importance of stromal interaction molecule 1 (STIM1) mRNA a...
Integrative Genomic Analysis Identifies MAGT1 as a Key Regulator of Proliferation and Poor Prognosis in Breast Cancer [0.03%]
Liwen Zhao,Zhe Song
Liwen Zhao
Objective: Magnesium transporter 1 (MAGT1) plays a crucial role in magnesium homeostasis and immune regulation, yet its clinical significance and functional role in breast cancer remain largely unexplored. ...
A Combined Transcriptomic and Machine Learning Study Reveals PAX8 as a Promising Diagnostic Biomarker in Endometriosis [0.03%]
Xiaoli Zhu,Li Zhong,Yanlin Xu et al.
Xiaoli Zhu et al.
Background: Endometriosis (EM) is a chronic, estrogen-dependent disease that lacks reliable noninvasive diagnostic biomarkers. This study was aimed at evaluating the diagnostic value of PAX8 using integrated transcriptomi...
A De Novo Mutation (c.2423A>G) in SAMD9 Causing MIRAGE Syndrome With Intrauterine Growth Retardation and Renal Hypoplasia in a Chinese Family [0.03%]
Yuxin Huang,Jiahui Fu,Zhongzhi Gan et al.
Yuxin Huang et al.
Background and aims: MIRAGE syndrome is an autosomal-dominant genetic disease primarily caused by a de novo mutation in the gene SAMD9 gene. This study is aimed at investigating the pathogenesis of MIRAGE syndrome through...
Case Reports
Human mutation. 2026 Apr 17:2026:9470286. DOI:10.1155/humu/9470286 2026