Formulation and evaluation of buccal films loaded with insulin encapsulated in glucose responsive amphiphilic dendrimer micelles [0.03%]
包载葡萄糖响应两亲性树状高分子胶束的胰岛素颊粘膜片的设计与评价
Dana R Dweekat,Suhair S Al-Nimry,Ayat A Bouzieh
Dana R Dweekat
The objective was to prepare amphiphilic dendrimer micelles nanoparticles (APN micelles NPs) loaded with insulin and formulating them into a mucoadhesive buccal film. The APD micelles NPs were synthesized by a series of chemical reactions f...
Eudragit-Based Electrospun Nanofibers for Improving the Solubility and permeability of Cefditoren Pivoxil: In-vitro, Ex-vivo and Histological assessment [0.03%]
基于Eudragit的静电纺纳米纤维通过体外，离体和组织学评价改善戊氧辛 cephditoran 的溶解度及渗透性
Doaa A Habib,Omar Y Mady,Youstina Samuel Saliby et al.
Doaa A Habib et al.
The dual solubility enhancement effect of nanofiber technology and pH-sensitive Eudragit L100-55 and S100 on class IV Cefditoren pivoxil (CEF) was studied. Nanofibers of different drug-polymer ratios were prepared. In-vitro characterization...
Thermosensitive hydrogel with nanostructured lipid carriers (NLC) for the topical administration of curcuminoids, resveratrol, and piperine intended for the treatment of psoriasis [0.03%]
纳米结构脂质载体(NLC)热敏水凝胶经局部给药输送姜黄素、白藜芦醇和胡椒碱用于治疗银屑病
Alegre Flores-Pérez,Rosa María Angeles-Villegas,Angélica Villanueva-Martínez et al.
Alegre Flores-Pérez et al.
Chronic inflammatory conditions, such as psoriasis, require effective therapeutic strategies to manage both local and systemic inflammation. This study aimed to develop a thermosensitive hydrogel (Gel) based on Pluronic F127 and F68, incorp...
Development of sustained release oral disintegrating tablet of fluvoxamine maleate [0.03%]
马来氧氮平口崩片的研制开发研究进展
Esraa A Shetaa,Mona F Arafa,Sally E Abu-Risha et al.
Esraa A Shetaa et al.
Fluvoxamine maleate is efficient in treatment of depression and obsessive-compulsive disorder. However, it has several side effects which are believed to be minimized by administration of slow-release formulation. This work introduces geria...
Co-delivery of Doxorubicin and Piperine using niosomes exhibited enhanced cytotoxic and inhibitory effect on cancer stem cell markers in Breast Cancer Cells [0.03%]
阳离子囊泡联合输送多西他赛和胡椒碱可在乳腺癌细胞中协同抑制癌症干细胞属性
Mohadese Sheikhhosseini,Sara Soltanian,Neda Mohamadi
Mohadese Sheikhhosseini
Combination therapy with chemotherapy and phytochemical drugs is a promising cancer treatment method. In this study, noisome with Tween 20, span 40 and cholesterol in 80:20 ration was prepared for co-delivery of piperine (PIP) and doxorubic...
TSA-SAB Co-Loaded Liposome Self-Dissolving Microneedle Synergistic Delivery System: A Breakthrough Dual-Drug Loading Strategy for Multi-Target Therapy of Hypertrophic Scars [0.03%]
载TSA和SAB的共载脂质体自溶解微针协同递送系统：瘢痕增生多靶点治疗的双重药物负载策略新突破
Lu-Lu Cheng,Jia-Hui Yu,Bi-Jin Yao et al.
Lu-Lu Cheng et al.
The treatment of hypertrophic scars is constrained by inefficient transdermal delivery and challenges in co-delivery of multiple drugs. Although tanshinone IIA and salvianolic acid B exhibit multi-target antifibrotic potential, their diverg...
Rational Design and Relative Bioperformance of High Drug Load Grazoprevir Amorphous Nanoparticle Formulations [0.03%]
高载药量 grazoprevir 无定形纳米粒制剂的理性设计及相对生物性能研究
Joseph Della Rocca,Cory Bottone,Majid Mahjour et al.
Joseph Della Rocca et al.
This work looked to determine if a rationally designed amorphous nanoparticle formulation of Grazoprevir (GZP) could provide a benefit over its amorphous dispersion formulation by either enabling superior bioperformance or accessing higher ...
Exploring Stabilizing Agents to Prevent Crystal Growth or Aggregation in PTX-NCs Generated via Diverse Nanocrystallization Technologies [0.03%]
探究稳定剂在PTX-NCs中的应用以防止晶体生长或聚集
Farzaneh Amiri,Ali Nokhodchi,Mohammad Barzegar-Jalali et al.
Farzaneh Amiri et al.
This study aimed to prepare paclitaxel nanocrystals (PTX-NCs) for the development of a delivery platform for this poorly water-soluble drug. Herein, using biocompatible polymers as stabilizers, paclitaxel (PTX) was formulated as a nanosuspe...
Formulation and Characterization of a Fixed-Dose Microemulsion Containing Efavirenz, Emtricitabine, and Tenofovir [0.03%]
含依法韦恩、恩曲他滨和替诺福韦的固定剂量微乳处方及特性研究
Samantha Mabvira,Sandile M Khamanga,Roderick B Walker
Samantha Mabvira
Despite a marked decrease in HIV/AIDS-related mortality, HIV remains one of the leading causes of death in specific populations. Despite concerted efforts to find a cure for HIV, to date, none exists. Current antiretroviral therapy inhibits...
Novel Vanillic Acid-Loaded In Situ Gels: Development, Characterization, In Vitro Evaluation for Enhanced Wound Healing and Skin Irritation Test [0.03%]
新型 vanillic acid 药物负载型原位凝胶的开发、表征及体外评价和皮肤刺激试验
Gökçe Mutlu Sonat,Emre Şefik Çağlar,Dilara Güreşçi et al.
Gökçe Mutlu Sonat et al.
This study aimed to develop in situ gel formulations containing vanillic acid to enhance patient compliance and accelerate wound healing. Vanillic acid-loaded in situ gels were prepared and their physicochemical properties were evaluated th...