Innovative Nanotechnological Approaches to Diabetes Treatment: The Role of Metal Oxide Nanoparticles [0.03%]
纳米技术创新在糖尿病治疗中的应用——金属氧化物纳米颗粒的作用
Eman E Shaban,Mahmoud E Abd El-Aziz
Eman E Shaban
Diabetes mellitus (DM) is among the most prevalent illnesses in the world. DM and its complications lead to high mortality rates. The negative effects of traditional diabetic therapies, such as insulin and metformin, include weight gain, hy...
Design and Characterization of Quercetin-Embedded Biocomposite Hydrogel for the Management of Polycystic Ovary Syndrome: A Dual In Vitro and In Vivo Approach [0.03%]
一种用于管理多囊卵巢综合征的檞皮素负载生物复合水凝胶的设计与表征：体内外综合方法
Koushik Ghosh,Ahana Hazra,Ishika Dey et al.
Koushik Ghosh et al.
Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. PCOS is a common endocrinopathy in young women, causing androgen excess, insulin resistance, obesity, c...
Ex Vivo and In Vivo Evaluation of an In Situ Nanogel Composite loaded with Carmustine: Implications for efficient nose-to-brain delivery [0.03%]
载卡莫司汀就地纳米凝胶复合材料的体外及在体评价：有效鼻脑给药的可行性研究
Olufemi D Akilo,Pradeep Kumar,Lisa C Du Toit et al.
Olufemi D Akilo et al.
In this study, the efficacy of a Nanogel Composite was evaluated and compared to the conventional drug carmustine (BCNU) through ex vivo and in vivo studies using New Zealand White rabbits. The Nanogel Composite is a thermosensitive, electr...
Enhanced solubility and controlled release of probucol using electrospun nanofibers prepared with different pharmaceutical polymers [0.03%]
采用不同的药用聚合物制备的电纺纳米纤维提高probucol的溶解度及实现其控释
Saki Arakawa,Kouji Hara,Yoko Koide et al.
Saki Arakawa et al.
We aimed to improve the water solubility and control the release of probucol using electrospinning technology. The effects of multiple polymer matrices and surfactants on the water solubility of probucol were evaluated. Probucol-loaded nano...
Self-assembled zanubrutinib loaded lipid polymer hybrid nanoparticles for enhanced oral absorption by lymphatic uptake: in vitro, ex vivo and in vivo evaluations [0.03%]
一种自组装的zanubrutinib载药脂质聚合物混合纳米颗粒用于增强口腔吸收和淋巴靶向：体外，组织外和体内评估
Mitali Patel,Rahul Parmar,Vrushti Kansara et al.
Mitali Patel et al.
The application of zanubrutinib (ZBR) is limited by poor aqueous solubility (0.0103 mg/ml) and low oral bioavailability (15%) owing to extensive metabolism by CYP3A4 enzyme and P-glycoprotein (P-gp) efflux. Hence, self-assembled lipid-polym...
Current and Emerging Therapies for Dry and Neovascular Age-related Macular Degeneration [0.03%]
老年性黄斑变性的当前及新兴疗法：于干性和新生血管型之间的抉择
Ghayth M Abdulrazzaq,Marwan M Merkhan,Nashiru Billa et al.
Ghayth M Abdulrazzaq et al.
An injectable ropivacaine and lornoxicam sustained-release gel regulated by low molecular weight poly(ortho esters) [0.03%]
由低分子量顺式交联聚正酯调控的罗哌卡因和洛尼昔康长效缓释凝胶注射剂
Xianzhi Wu,Xiaoan Li,Zhannuan Yin et al.
Xianzhi Wu et al.
Persistent postoperative pain is commonly occurred after surgical procedures, while over half of patients suffer from poorly controlled pain, due to the limited therapeutic period of commercial drugs and suboptimal drug delivery strategy. H...
Preparation, Characterization and Drug Release Properties of 5-(p-Carboxyphenoxy) valeric Anhydride Microspheres Loaded with Nimodipine [0.03%]
5-(对羧基苯氧)戊酸酐载尼莫地平微球的制备、表征及药物释放性能研究
Sibo Su,Jingguo Liu,Yongxue Guo
Sibo Su
Nimodipine (NMP), a poorly water-soluble small-molecule agent, demonstrates notable therapeutic limitations in addressing cerebral vasospasm secondary to subarachnoid hemorrhage (SAH). Owing to its inherent physicochemical properties charac...
D-optimal design-based optimization of Etoricoxib cubogel for management of arthritis; In vitro and in vivo Evaluation [0.03%]
基于D-最优设计的埃托考西布库巴凝胶治疗关节炎的优化及体内外评价
Marwa H Abdo,Marwa A Abd El-Fattah,Heba A Eassa et al.
Marwa H Abdo et al.
Etoricoxib (Et) is selective COX-2 inhibitor with several drawbacks after oral administration. Current study focused on formulating targeted Et cubogel for management of osteoarthritis. Interaction between formulation factors; (glyceryl-mon...
Strontium alginate hybrid (inorganic/organic) nanoparticles as a novel promising nanosystem for bone regeneration: In-vitro optimization and In-vivo assessment [0.03%]
新型用于骨再生的硫酸锶藻酸盐杂化(无机/有机)纳米颗粒：体外优化和体内评估
Nouran M Atia,Hebatallah S Barakat,Heba A Hazzah et al.
Nouran M Atia et al.
Strontium (Sr) is a bone-seeking element characterized by its dual function of stimulating bone growth and preventing bone resorption. On the other hand, alginates (Alg) have distinct physicochemical characteristics from other natural polys...