Self-assembled zanubrutinib loaded lipid polymer hybrid nanoparticles for enhanced oral absorption by lymphatic uptake: in vitro, ex vivo and in vivo evaluations
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The application of zanubrutinib (ZBR) is limited by poor aqueous solubility (0.0103 mg/ml) and low oral bioavailability (15%) owing to extensive metabolism by CYP3A4 enzyme and P-glycoprotein (P-gp) efflux. Hence, self-assembled lipid-polymer hybrid nanopartic... ...
