Fabrication and Evaluation of Felodipine Push-Pull Osmotic Pump Capsule [0.03%]
酚妥拉明 push-pull 渗透泵胶囊的制备及评价
Chaowalit Monton,Poj Kulvanich
Chaowalit Monton
Felodipine is traditionally delivered as extended-release tablets, but a push-pull osmotic pump (PPOP) capsule represents a promising alternative platform for controlled-release delivery. This work sought to characterize properties of the f...
Correction [0.03%]
改正通知书
Published Erratum
Pharmaceutical development and technology. 2025 Dec 24:1. DOI:10.1080/10837450.2025.2607906 2025
Nitogenin-PEG Succinate Micelles for Curcuminoid Delivery: Synthesis, In vitro Cytotoxicity, and In vivo Pharmacokinetics" [0.03%]
用于输送类姜黄素的氮杂乙内酰亚胺-聚乙二醇琥珀酸酯micelles的合成，体外细胞毒理以及体内药代动力学研究
Varsha Velmurugan,Velmurugan Shanmugham,RameshKumar Angappan
Varsha Velmurugan
In the present study, three kinds of curcuminoids (CS)-loaded micelles (CS-NPGS) were prepared by the solid dispersion method using novel Nitogenin polyethylene glycol succinate-1000 (NPGS-1000) to enhance the solubility and bioavailability...
Fabrication of baicalin solid dispersion using the supercritical anti-solvent technology: optimization, characterization, and evaluation [0.03%]
超临界反溶剂技术制备汉黄芩素固体分散体：优化、表征和评价
Mingming Wang,Zan Sun,Jian Hu et al.
Mingming Wang et al.
Baicalin is a flavonoid glycoside with substantial biological activity and pharmacological effects, primarily extracted from Scutellaria baicalensis Georgi. However, its clinical implementation has been impeded by suboptimal aqueous solubil...
Quality by Design (QbD) Development of a Soluplus/TPGS-based Ternary Amorphous Solid Dispersion for Enhanced Oral Bioavailability of Acacetin [0.03%]
基于Soluplus/TPGS的三元无定形固体分散体制备机制及提高金光素口服生物利用度研究
Jianghai He,Yanyan Zhen,Qian Chen et al.
Jianghai He et al.
Acacetin, a natural flavonoid with high-melting-point (> 200 °C) and poorly aqueous solubility, presents significant challenges in oral bioavailability due to its low dissolution rate. To address this limitation, acacetin-loaded amorphous ...
AI-Guided Real-Time Detection of Flow Irregularities and Bottlenecks in Pharmaceutical Vial Filling Lines Using Vision-Based Models [0.03%]
基于视觉模型的制药瓶填充线中流动不规则和瓶颈的实时检测方法
Sai Vijay Thattukolla,Sai Vinay Thattukolla
Sai Vijay Thattukolla
Aim/background: Ensuring smooth and consistent vial flow on pharmaceutical filling line conveyors is essential for maintaining sterility, reducing downtime, and avoiding costly disruptions. However, irregular vial movemen...
Design of experiments to optimize gallic acid carbon-based nanoparticle synthesis for enhanced photodynamic therapy in cancer cells [0.03%]
一种用于增强癌细胞光动力疗法的没食子酸类碳基纳米粒子的优化合成方法的设计与试验
Koranat Dechsri,Supusson Pengnam,Thapakorn Charoenying et al.
Koranat Dechsri et al.
Carbon-based nanoparticles (CNPs) have attracted significant attention as photosensitizers for photodynamic therapy (PDT) due to their biocompatibility, facile synthesis, and ability to generate reactive oxygen species (ROS). In this study,...
Redox-responsive palbociclib-loaded self-assembled protein nanoparticles in breast cancer therapy-quality by design approach and efficacy assessment in 2D and 3D in vitro culture systems [0.03%]
基于质量设计的乳腺癌治疗中具有还原响应和载药功能的蛋白基自组装纳米颗粒及其二维和三维体外细胞体系中的疗效评估研究
Ujala Gupta,Rahul Kumar,Anamika Sharma et al.
Ujala Gupta et al.
Redox-responsive nanocarriers exploit the unique intracellular redox environment to enable targeted and controlled release of therapeutic agents. The present study comprises the fabrication of Palbociclib-bearing Bovine serum albumin-based ...
Surfactant-Based Drug Delivery Strategies for HIV/AIDS Therapy: Advances in Formulation and Clinical Translation [0.03%]
基于表面活性剂的HIV/AIDS治疗给药策略：制剂及临床转化研究进展
Karuppiah Nagaraj
Karuppiah Nagaraj
The Human Immunodeficiency Virus (HIV) is a major global health concern, demanding the ongoing development of novel therapy techniques. Antiretroviral therapy (ART) has considerably increased the life expectancy of HIV patients; yet, obstac...
A High-Energy Ultrasonication Strategy for the Development and Stabilization of Astaxanthin Nanoemulsions: Formulation Optimization and Antioxidant Evaluation [0.03%]
一种用于虾青素纳米乳化液的开发与稳定化的高能超声策略：配方优化和抗氧化性能评估
Moh Aijaz,Arun Kumar
Moh Aijaz
Astaxanthin (AXT), a xanthophyll carotenoid with strong antioxidant and therapeutic potential, faces limitations in clinical applications due to its poor solubility, instability, and low oral bioavailability. This study aimed to enhance AXT...