Quality by Design (QbD) Development of a Soluplus/TPGS-based Ternary Amorphous Solid Dispersion for Enhanced Oral Bioavailability of Acacetin
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Acacetin, a natural flavonoid with high-melting-point (> 200 °C) and poorly aqueous solubility, presents significant challenges in oral bioavailability due to its low dissolution rate. To address this limitation, acacetin-loaded amorphous solid dispersion (AS... ...
