Engineering orally disintegrating tablets for buccal delivery of cilostazol with enhanced dissolution and bioavailability: a novel dual porogenic approach, in vitro characterization, and in vivo evaluation in rats [0.03%]
改良西洛他唑口腔崩解片以提高溶解度和生物利用度：一种新型双造孔方法，体外特征分析及体内大鼠评价研究
Shahinaze A Fouad,Nada Abdelaziz,Mahmoud H Teaima et al.
Shahinaze A Fouad et al.
Cilostazol (CTZ), is a BCS class II drug with limited bioavailability. In the current study, orally disintegrating tablets (ODTs) for buccal delivery of CTZ were prepared by two methods; lyophilization (Lyo-ODTs) and direct compression (DC-...
Ezetimibe Oral Solid Lipid Nanoparticle by Effervescent Dispersion Method: in Vitro Characterization And in Vivo Pharmacokinetic Study in Rats [0.03%]
采用泡腾分散法的Ezetimibe口服固体脂质纳米粒：体外特性和体内药代动力学大鼠研究
Ruba S Darweesh,Farah S AlQawasmi,Mai S Khanfar
Ruba S Darweesh
Ezetimibe (EZT) is a class II drug of the Biopharmaceutics classification system (BCS), with limited aqueous solubility and high permeability. This study aims to enhance the solubility and oral bioavailability of EZT by developing EZT solid...
Ocular polymeric nanomicelles for the posterior eye segment in the management of retinoblastoma: Formulation, optimization, in vitro and ex vivo evaluations [0.03%]
用于视网膜母细胞瘤后眼部管理的聚meric纳米胶束：制剂，优化，体内外评价
Mudassir Ansari,Yogesh A Kulkarni,Kavita Singh
Mudassir Ansari
The existing study focuses on the development, optimization, and evaluation of sorafenib-loaded polymeric nanomicelles for posterior segment delivery in treating retinoblastoma. The formulation involved adjusting various process and product...
Formulation and optimization of glycyrrhetinic acid-modified pH-sensitive curcumin liposomes for anti-hepatocellular carcinoma [0.03%]
甘草酸修饰的姜黄素pH敏感脂质体的制备及其抗肝癌作用研究
Jie Wang,Xuemei Gu,Xia Gao et al.
Jie Wang et al.
In order to enhance the therapeutic value of curcumin in liver cancer treatment, glycyrrhetinic acid-modified pH-sensitive curcumin liposomes (GA-pH-Lip@Cur) was developed.GA-pH-Lip@Cur was prepared using a thin film dispersion ultrasonicat...
Formulation development and evaluation of push-pull osmotic pump bi-layered tablets for phencynonate HCl in the treatment of motion sickness [0.03%]
用于治疗晕动病的盐酸苯甲辛双向渗透泵控释片剂的研发及评价研究
Si-Rui Liu,Wen Lin,Xiang-Yang Xie et al.
Si-Rui Liu et al.
The aim of this study was to develop and evaluate an extended-release (ER) push-pull osmotic pump (PPOP) tablet for phencynonate HCl (PCN), which could release the drug at zero-order profile for a duration of 24 h. The core tablets were des...
Long-Acting Release of Fluocinolone Acetonide Microspheres Using Electrospray Technology for Non-infectious Uveitis Therapy [0.03%]
使用电喷涂技术输送氟轻松 acetate 微球治疗非感染性葡萄膜炎的长效释放研究
Xie Jiayu,K E Li,Lusi Chen et al.
Xie Jiayu et al.
Intravitreous long-acting drug delivery system offers an excellent alternative to multiple injections for the treatment of non-infectious uveitis (NIU). However, the adverse effects of non-biodegradable intravitreal implants of fluocinolone...
Impact of Critical Process Parameters on the Dimensional, Mean Weight and Swelling Properties of 3D-Printed Intravaginal Rings: A Quality by Design approach [0.03%]
基于质量设计的3D打印阴道环尺寸、平均重量和溶胀特性的关键工艺参数影响研究
Gabrielle Silva de Campos Lazzarini,Guilherme Luíz Da Silva,Laís S Lacerda et al.
Gabrielle Silva de Campos Lazzarini et al.
3D printing has been emerging as a transformative technology in pharmaceutical manufacturing, offering potential for personalized medicine and innovative dosage forms. It enables precise control over drug release profiles and dosage customi...
Enhanced Dissolution and Antibacterial Potential of Cinacalcet Hydrochloride via Ternary Solid Dispersions [0.03%]
三元固体分散体增强cinacalcet氢氯化物的溶解度和抗菌潜力
Aya E Radwan,Ebtessam A Essa,Engy Elekhnawy et al.
Aya E Radwan et al.
Cinacalcet hydrochloride (HCl), a calcium-sensing receptor agonist used to treat hyperparathyroidism, suffers from poor solubility, reducing its bioavailability. Recently, cinacalcet HCl has been probed for repurposing as antibacterial agen...
Development of PLGA-SPC3 functionalized Gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: Biodistribution and Cytotoxicity analysis [0.03%]
开发用于乳腺癌靶向的PLGA-SPC3功能化的吉非替布中孔二氧化硅纳米支架：生物分布和细胞毒性分析
Ravi Kumar Sah,Sajeev KumarB
Ravi Kumar Sah
The exploration of novel carriers for cancer treatments is on the rise, as drugs are often hindered by ineffective delivery to the tumor site. In the present study, Mesoporous silica nano scaffolds were developed by novel heat assisted hydr...
Formulation and clinical evaluation of hyaluronic acid nanogel in treatment of tear trough: Nano-flipping from injectable fillers to topical nanofillers [0.03%]
透明质酸纳米凝胶制剂治疗眼周泪沟的临床研究：从注射填充剂到外用纳米填料
Yosra Sr Elnaggar,Abdelrahaman Mm Othman,Ashraf Farahat et al.
Yosra Sr Elnaggar et al.
Tear trough deformity (TTD) is a significant cosmetic concern, with current treatments relying primarily on invasive injectable fillers, which are costly and carry risks of complications. Despite the widespread use of hyaluronic acid (HA) i...