An insight into Cell-Penetrating Peptides: Perspectives on Design, Optimization, and Targeting in Drug Delivery Systems [0.03%]
细胞穿透肽在药物递送系统中的设计、优化及靶向作用的研究进展与展望
Ali Asghar Khakshur,Elham Khodaverdi,Hossein Kamali et al.
Ali Asghar Khakshur et al.
Objective: The authors carried out a comprehensive review of the application of peptides known as cell-penetrating peptides (CPPs) in various drug delivery systems (DDS), with the prospect of achieving novel solutions and...
Mucoadhesive Polymeric Film with Plant-Based Compounds for Dental Applications: Formulation, Characterization and Evaluation [0.03%]
含植物成分的口腔粘膜黏附聚乙烯基薄膜的制备、表征及评价研究
Yuliia Maslii,Nataliia Herbina,Lina Dene et al.
Yuliia Maslii et al.
Polymeric films are promising formulations for oromucosal drug delivery, particularly for localized treatment of dental diseases. This study focused on developing mucoadhesive films for dental applications, incorporating clove CO2 extract a...
Quercetin nanocrystals stabilized by glycyrrhizic acid for liver targeted drug delivery：Impact of glycyrrhizic acid concentrations [0.03%]
甘草酸稳定檞皮素纳米晶体的肝靶向递送效应及甘草酸浓度的影响研究
Wang Fengxia,Shen Chengying,Chen Fangwen et al.
Wang Fengxia et al.
The purpose of this study was to investigate the impact of glycyrrhizic acid (GL) concentrations on in vitro and in vivo behavior of quercetin (QT) nanocrystals stabilized by GL (QT-NCs/GL), with a particular focus on its influence on liver...
Design and Characterization of Memantine and Donepezil Loaded 3D Scaffolds [0.03%]
负载美金刚和多奈哌齐的三维支架的设计与表征
Betül Topçu İnce,Samuel Guieu,Selin Seda Timur et al.
Betül Topçu İnce et al.
Memantine HCl (MEM) and Donepezil HCl (DON) are widely used separately and in combination to treat Alzheimer's disease, and some studies suggest that these drugs may also prevent bone fractures and promote bone regeneration. For this purpos...
Nanoparticles co-loaded with sorafenib and emodin: preparation and efficacy against liver cancer in vitro and in vivo [0.03%]
纳米颗粒载 Sorafenib 和 Emodin 复合物的制备及其体内外抗肝癌活性
Yichun Jiang,Qiulan Li,Yan Chen et al.
Yichun Jiang et al.
Liver cancer is common worldwide and associated with relatively high mortality. Sorafenib is a first-line treatment for advanced liver cancer, but its efficacy is limited by its high toxicity, wide distribution in the body and low water sol...
Design, Fabrication, and In Vitro - In Vivo Evaluation of Surface-Engineered Pyrazinamide-Loaded Lipid Nanoparticles for Tuberculosis Therapy [0.03%]
一种用于结核病治疗的载有异烟肼的表面工程脂质纳米粒的设计、制备及体内外评价研究
Nimitt V Chokshi,Preksha Vinchhi,Shreyansh Chauhan et al.
Nimitt V Chokshi et al.
Pyrazinamide (PYZ), a nicotinamide derivative, is an essential first-line anti-TB drug. However, its dose-dependent hepatotoxicity poses a considerable challenge, accentuating the need for improved delivery approaches. The key objective of ...
Controlled anti-solvent precipitation for enhanced dissolution rate and antiplatelet activity of ticagrelor [0.03%]
控释抗溶剂沉淀技术制备高溶解度和抗血小板活性替格瑞洛晶体研究
Asmaa M Eldeeb,Dalia H Abdelkader,Gamal M El Maghraby
Asmaa M Eldeeb
The goal of our study is to augment ticagrelor (TC)'s dissolution rate and antiplatelet activity via controlled antisolvent precipitation. A saturated ethanolic solution of TC was prepared in the absence and presence of poloxamer 188 or gel...
Evaluating the color stability of titanium dioxide-free film coats under environmental and light stress [0.03%]
评估环境和光线压力对无二氧化钛包衣薄膜的颜色稳定性的评价
Jamie C L Chuvalo-Abraham,David Harris,Hyunho Kang et al.
Jamie C L Chuvalo-Abraham et al.
Titanium dioxide (TiO2) is an opacifier/colorant in tablet film coatings and capsule shells. Recently, questions about its safety have raised concerns that it may be banned from medicinal products in the European Union (EU); however, little...
Lessons Learned from the COVID-19 Pandemic: The Intranasal Administration as a route for treatment - A Patent Review [0.03%]
从COVID-19大流行中吸取的教训：作为治疗给药途径的鼻内给药-专利回顾
Nicole Menezes Pinto,Marcos Rafael das Chagas Mendonça,Jeferson da Silva Santos et al.
Nicole Menezes Pinto et al.
The COVID-19 pandemic exposed the fragility of today's marketed treatments for respiratory infections. As a primary site of infection, the upper airways may represent a key access route for the control and treatment for these conditions. Th...
Enhancing Ocular Drug Delivery: Development and In Vivo Evaluation of Mucoadhesive Nanostructured Lipid Carriers for Terbinafine [0.03%]
用于特比萘芬的黏膜粘附型纳米结构脂质载体的开发及活体评价：提高眼部药物递送性能的研究
Tarek A Samra,Ibrahim A Elbahwy,Hammam A Mowafy et al.
Tarek A Samra et al.
This study investigated incorporating Terbinafine Hydrochloride (TH) into chitosan-coated nanostructured lipid carrier (NLCs) to improve ocular treatment for fungal keratitis. Solubility studies were conducted to determine the most suitable...