Newly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection [0.03%]
新募集的上皮内Ly6A+CCR9+CD4+ T细胞可抵抗肠道病毒感染
Roham Parsa,Mariya London,Tiago Bruno Rezende de Castro et al.
Roham Parsa et al.
The intestinal epithelium comprises the body's largest surface exposed to viruses. Additionally, the gut epithelium hosts a large population of intraepithelial T lymphocytes, or IELs, although their role in resistance against viral infectio...
Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing [0.03%]
树突状细胞可以通过主要组织相容性复合体交叉着装来引发抗肿瘤CD8+t细胞反应
Brendan W MacNabb,Sravya Tumuluru,Xiufen Chen et al.
Brendan W MacNabb et al.
Antigen cross-presentation, wherein dendritic cells (DCs) present exogenous antigen on major histocompatibility class I (MHC-I) molecules, is considered the primary mechanism by which DCs initiate tumor-specific CD8+ T cell responses. Here,...
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs [0.03%]
阿司匹林等消炎止痛药的消炎作用机制
Anna Eisenstein,Brandon K Hilliard,Scott D Pope et al.
Anna Eisenstein et al.
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) enzymes and are ubiquitously used for their anti-inflammatory properties. However, COX inhibition alone fails to explain numerous clinical outcomes of NSAID usage. S...
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis [0.03%]
肠道微生物通过cGAS-STING-I型干扰素轴启动系统性抗病毒免疫响应
Saskia F Erttmann,Patrycja Swacha,Kyaw Min Aung et al.
Saskia F Erttmann et al.
The microbiota are vital for immune homeostasis and provide a competitive barrier to bacterial and fungal pathogens. Here, we investigated how gut commensals modulate systemic immunity and response to viral infection. Antibiotic suppression...
Justin L McCarville,Janelle S Ayres
Justin L McCarville
The mechanisms of how infectious diseases contribute to allergy remain unanswered. In this issue of Immunity, Agaronyan et al. (2022) show that Pseudomonas aeruginosa drives immune deviation through induction of type 2 immune responses, res...
Jonas J Neher
Jonas J Neher
Although consistently implicated, the exact role of interferon (IFN) signaling in Alzheimer's disease remains largely unexplored. Roy et al. now demonstrate that type I IFNs may drive cognitive dysfunction through acting not only on microgl...
Erika J Hughes,David M Tobin
Erika J Hughes
In this issue of Immunity,Gideon et al. (2022) couple sophisticated single-cell analyses with detailed in vivo measurements of Mycobacterium tuberculosis granulomas to define the cellular and transcriptional properties of a successful host ...
Immunity to enteric viruses [0.03%]
肠病毒的免疫性
Ainsley Lockhart,Daniel Mucida,Roham Parsa
Ainsley Lockhart
Pathogenic enteric viruses are a major cause of morbidity and mortality, particularly among children in developing countries. The host response to enteric viruses occurs primarily within the mucosa, where the intestinal immune system must b...
Leonel Ampie,Dorian B McGavern
Leonel Ampie
Neuroanatomical barriers with physical, chemical, and immunological properties play an essential role in preventing the spread of peripheral infections into the CNS. A failure to contain pathogens within these barriers can result in very se...
Mucosal immune responses to infection and vaccination in the respiratory tract [0.03%]
呼吸道感染和疫苗接种的黏膜免疫反应
Robert C Mettelman,E Kaitlynn Allen,Paul G Thomas
Robert C Mettelman
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive immune responses in the respiratory tract are tightly regulated and...