Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development [0.03%]
高效且持续的滤泡辅助性T细胞反应与增强的中和抗体发育相关
Ester Marina-Zárate,Henry J Sutton,Paul G Lopez et al.
Ester Marina-Zárate et al.
Durability of T follicular helper (Tfh) cell responses is pivotal for generating high affinity antibodies. We characterized Tfh cell responses to HIV Env immunization longitudinally in non-human primates, analyzing >500,000 CD4+ T cells fro...
Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program [0.03%]
长寿命的IgE浆细胞通过navitoclax敏感的存活程序在次级淋巴组织中持续存在
Zhoujie Ding,Mark R Dowling,Adam K Wade-Vallance et al.
Zhoujie Ding et al.
Long-term allergies can exhibit persistent concentrations of circulating immunoglobulin E (IgE). Here, we examined the lifespan of IgE antibody-secreting cells (ASCs) to determine whether the IgE that sustains allergies receives contributio...
A myeloid Tet2-IL-1β axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation [0.03%]
髓系Tet2-IL-1β轴通过限制肾上腺素能刺激肠嗜铬细胞分化来调节肠道炎症反应
Deepika Sharma,Ankit Malik,Veronica Locher et al.
Deepika Sharma et al.
Deciphering multicellular interactions is essential to understanding immune-mediated diseases. Myeloid cells can coordinate inflammatory responses and are central to immune crosstalk with neuronal, epithelial, and stromal cells. Here, we sh...
Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma [0.03%]
肠道菌群衍生的丁酸盐通过FOXO1诱导的干细胞程序促进CD8+T细胞免疫以抵抗黑色素瘤
Annabell Bachem,Michele Clarke,Geraldine Kong et al.
Annabell Bachem et al.
A range of microbiota species correlate with improved cancer outcomes in patients and confer protection in pre-clinical mouse models. Here, we examined how microbiota regulate CD8+ T cell immunity against melanoma. Spontaneous control of cu...
George Q Daley
George Q Daley
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells [0.03%]
NFATc1介导的TCR信号传导可限制IL-15诱导的人记忆CD8⁺T细胞旁观者活化
Hoyoung Lee,So-Young Kim,Sang-Hoon Kim et al.
Hoyoung Lee et al.
Human memory CD8+ T cells can undergo T cell receptor (TCR)-independent activation by interleukin-15 (IL-15) in a bystander manner. Bystander-activated CD8+ T cells contribute to host tissue injury through natural killer (NK)-like cytotoxic...
Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma [0.03%]
髓系细胞介导晚期肾细胞癌中干扰素引起的免疫疗法抵抗作用
Kevin Bi,Soki Kashima,Sabrina Y Camp et al.
Kevin Bi et al.
Sustained type-I and type-II interferon (IFN) signaling can drive multiple mechanisms of resistance to immune checkpoint blockade (ICB). Here, we used single-cell RNA sequencing data to characterize the effects of IFNs in the tumor-immune m...
Human immune aging [0.03%]
人类免疫衰老
Marina Terekhova,Pavla Bohacova,Maxim N Artyomov
Marina Terekhova
Aging is an essential aspect of human life, and studying its mechanisms is crucial for extending lifespan and improving quality of life. The immune system plays a central role in the onset of age-related diseases. Understanding the differen...
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors [0.03%]
基因组拷贝数变异驱动获得性免疫检查点抑制剂抗性的凋亡逃逸机制
Mingming Wu,Shiyue Yang,Zhentao Yang et al.
Mingming Wu et al.
Patients who initially respond to immune checkpoint inhibitors (ICIs) often relapse. Here, we studied how disease-progressive (DP) clinical melanomas evolve genomically to acquire ICI resistance. Compared to patient-matched pretreatment tum...
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response [0.03%]
定位在脾脏的长寿命IgE浆细胞参与了IgE应答的持续存在
Mariana C G Miranda-Waldetario,Edgar Gonzalez-Kozlova,Edenil C Aguilar et al.
Mariana C G Miranda-Waldetario et al.
Expression of the IgE BCR is associated with increased B cell apoptosis, yet in persistent allergy, sustained production of IgE antibodies in the absence of allergen exposure suggests the existence of long-lived IgE plasma cells (PCs). Here...