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TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells

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Human memory CD8+ T cells can undergo T cell receptor (TCR)-independent activation by interleukin-15 (IL-15) in a bystander manner. Bystander-activated CD8+ T cells contribute to host tissue injury through natural killer (NK)-like cytotoxicity during viral inf... ...