IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy [0.03%]
白细胞介素9作为工程t细胞治疗的理想细胞因子：与天然信号通路正交的jak/stat信号激活剂
Hua Jiang,Sam Limsuwannarot,Kayla R Kulhanek et al.
Hua Jiang et al.
Cytokines and their receptors enable precise tuning of T cell function. Leveraging this biology holds tremendous promise for optimizing antitumor immunity. Arming T cells with a synthetically orthogonal interleukin (IL)-9 receptor (o9R), fo...
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells [0.03%]
逐次类别转换生成抗原特异的肠道IgA免疫球蛋白来自IgG1B细胞
Emily R Siniscalco,Hailong Meng,Gisela Gabernet et al.
Emily R Siniscalco et al.
Immunoglobulin (Ig)A is the primary isotype protecting the gut barrier, yet fundamental aspects of antigen-specific IgA induction remain unknown. Gut lymphoid organs are chronically exposed to foreign antigens, are structurally different fr...
Glymphatics and meningeal lymphatics unlock the brain-immune code [0.03%]
脑淋巴系统和glymphatic通道解锁脑免疫新认知
Min Woo Kim,Jonathan Kipnis
Min Woo Kim
Published Erratum
Immunity. 2025 Nov 13:S1074-7613(25)00512-6. DOI:10.1016/j.immuni.2025.11.010 2025
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry [0.03%]
FOXP3的表达依赖于特定细胞类型的顺式调控元件和转录因子回路
Jennifer M Umhoefer,Maya M Arce,Sivakanthan Kasinathan et al.
Jennifer M Umhoefer et al.
FOXP3 is a lineage-defining transcription factor (TF) for immune-suppressive regulatory T cells (Treg cells). Although mice exclusively express FOXP3 in Treg cells, stimulated conventional CD4+ T cells (Tconv cells) also transiently express...
Tame the Hydra's head: Targeting bone marrow maladaptive myelopoiesis to reverse macrophage-mediated immunosuppression in cancer [0.03%]
斩断水怪之首：靶向骨髓适应不良粒系增生逆转肿瘤相关巨噬细胞介导的免疫抑制
Zheng Jin,Bo Zhu
Zheng Jin
Immunosuppressive monocyte-derived macrophages are key targets in cancer therapy; however, the mechanisms of their replenishment and functional plasticity remain elusive. In a recent issue of Nature, Hedge et al. challenge the conventional ...
Hocheol Shin,Joon Seok Park
Hocheol Shin
Gut microbial metabolites modulate immune responses to tumors. In this issue of Immunity, Bachem et al.1 demonstrate that microbiota-derived butyrate cooperates with the transcription factor Foxo1 to promote CD8+ T cell stemness and enhance...
Maria Backhaus,Kai Markus Schneider
Maria Backhaus
Sympathetic signaling has been implicated in colitis, but the precise circuits remain unclear. In this issue of Immunity, Sharma et al. demonstrate that myeloid cell-specific loss of DNA-demethylation dampens sympathetic signaling-driven co...
Justine Fiefvet,Lidia Yshii
Justine Fiefvet
Regulatory T cells can play conflicting roles in autoimmune inflammation. In this issue of Immunity, Benamar et al. reveal that gut-microbiota-induced Notch3+ regulatory T cells migrate to the central nervous system in multiple sclerosis an...
Hidden survivors: Long-lived IgE-secreting plasma cells in the spleen [0.03%]
隐藏的幸存者：脾脏中长寿的IgE分泌型浆细胞
Vassilis Glaros,Taras Kreslavsky
Vassilis Glaros
Until recently, the existence of long-lived IgE-secreting plasma cells was debated. Using timestamping in mouse models of type 2 inflammation, two studies in this issue of Immunity reveal the long-term persistence of IgE-secreting plasma ce...
Aging and immunity [0.03%]
衰老与免疫系统
Christoph A Thaiss,Ye Tian,Daniel A Winer et al.
Christoph A Thaiss et al.
Time marches endlessly on … but what does that mean for the immune system? Here, investigators discuss how aging impacts the immune response and how immune cells can shape the aging process, with broader implications for modifying immunity...