Juan Zhang,Qiang Liu
Juan Zhang
Immunotherapeutic approaches to brain aging remain largely preclinical and in early translational stages, and they have focused mostly on modulating innate immunity. In this issue of Immunity, Negredo et al. identify T cells bearing exhaust...
Yuchao Jing,Jie Zhou
Yuchao Jing
Tissue inflammation introduces unique, and often harsh, environments for immune cells. During allergic airway inflammation, pathogenic ILC2s proliferate robustly and drive pathology, but how do they overcome the nutrient-depleted environmen...
Takahiro Masuda
Takahiro Masuda
Microglia display remarkable plasticity, with their cellular states evolving in response to developmental stage, regional context, and environmental or pathological stimuli. In this issue of Immunity, Hamagami et al. demonstrate that adapti...
Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart [0.03%]
流感病毒利用髓系细胞诱发的心脏I型干扰素损伤机制研究
Jeffrey Downey,Ana Oliveira-Coelho,Máté G Kiss et al.
Jeffrey Downey et al.
Abundant evidence has correlated influenza infection with cardiovascular disease, yet mechanisms linking infection with the heart remain poorly understood. Here, we show that influenza infection damaged the human and murine heart. In mice, ...
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer's disease risk factors [0.03%]
INPP5D通过抑制RIPK1激酶活性来抑制多种促炎介质及阿尔茨海默病风险因子的表达
Xingxing Xie,Jianping Liu,Wei Liang et al.
Xingxing Xie et al.
Genome-wide association studies strongly implicate neuroinflammation in late-onset Alzheimer's disease (LOAD). Genetic risk loci for LOAD are enriched for genes expressed in microglia, but the relationship among microglial LOAD risk genes h...
Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals [0.03%]
在未接触受感染牛的流感A型病毒H5N1的人群中可检测到预先存在的中和抗体
Katharina Daniel,Leon Ullrich,Denis Ruchnewitz et al.
Katharina Daniel et al.
The transmission of influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of an H5N1 pandemic. Pre-existing immunity strongly impacts the course and severity of viral infections, making detailed knowledge of antibo...
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition [0.03%]
靶向衰老大脑中的免疫细胞发现改造型细胞因子IL-10可增强神经发生并改善认知能力
Paloma Navarro Negredo,Justin You,Max Hauptschein et al.
Paloma Navarro Negredo et al.
The immune system could play an important role in the age-related decline in brain function, yet specific immune-based strategies to enhance brain resilience in older individuals are lacking. Here, we combined engineered proteins and direct...
Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes [0.03%]
逐步表观信号整合驱动细胞毒性淋巴细胞的适应性编程
Simon Grassmann,Endi K Santosa,Hyunu Kim et al.
Simon Grassmann et al.
Lymphocyte differentiation during infection depends on the integration of antigen and cytokine signals, yet how the timing and sequence of these cues program cell fate remains unclear. We found that interleukin-12 (IL-12) plays a context-de...
B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells [0.03%]
B细胞固有的IL-2信号通过促进CD25+年龄相关的B细胞中IL-10的表达来调节炎症反应
Juliette Gauthier,Maxime Maugendre,Simon Léonard et al.
Juliette Gauthier et al.
Interleukin (IL)-2 can impact both plasma cell (PC) differentiation and the generation of IL-10pos B cells. We generated mice bearing a B cell-specific deletion of Il2rb (Il2rbΔB) to define the B cell-intrinsic role of IL-2. Il2rbΔB mice ...
Dianyu Chen,Heping Xu
Dianyu Chen
The meninges, long viewed as passive protective membranes, are now recognized as active immunological interfaces harboring diverse immune populations. Among them, B cells have emerged as dynamic participants in central nervous system (CNS) ...